Results 11 to 20 of about 29,893 (236)

A Genome-wide Map of CTCF Multivalency Redefines the CTCF Code [PDF]

Cell Reports, 2013
The “CTCF code” hypothesis posits that CTCF pleiotropic functions are driven by recognition of diverse sequences through combinatorial use of its 11 zinc fingers (ZFs).
Hirotaka Nakahashi, Kyong-Rim Kieffer Kwon, Wolfgang Resch, Laura Vian, Marei Dose, Diana Stavreva, Ofir Hakim, Nathanael Pruett, Steevenson Nelson, Arito Yamane, Jason Qian, Wendy Dubois, Scott Welsh, Robert D. Phair, B. Franklin Pugh, Victor Lobanenkov, Gordon L. Hager, Rafael Casellas   +17 more
doaj   +4 more sources

CGGBP1 regulates CTCF occupancy at repeats

Epigenetics & Chromatin, 2019
Background CGGBP1 is a repeat-binding protein with diverse functions in the regulation of gene expression, cytosine methylation, repeat silencing and genomic integrity. CGGBP1 has also been identified as a cooperator of histone-modifying enzymes and as a
Divyesh Patel, Manthan Patel, Subhamoy Datta, Umashankar Singh   +3 more
doaj   +4 more sources

Predicting CTCF-mediated chromatin loops using CTCF-MP [PDF]

Bioinformatics, 2018
Abstract The three dimensional organization of chromosomes within the cell nucleus is highly regulated. It is known that CTCF is an important architectural protein to mediate long-range chromatin loops. Recent studies have shown that the majority of CTCF binding motif pairs at chromatin loop anchor regions are in convergent orientation.
Ruochi Zhang, Yuchuan Wang, Yang Yang 0094, Yang Zhang 0042, Jian Ma 0004   +4 more
openaire   +4 more sources

CTCF Recruits Centromeric Protein CENP-E to the Pericentromeric/Centromeric Regions of Chromosomes through Unusual CTCF-Binding Sites [PDF]

Cell Reports, 2015
The role of CTCF in stabilizing long-range interactions between chromatin sites essential for maintaining nuclear architecture is well established. Most of these interactions involve recruitment of the cohesin complex to chromatin via CTCF.
Tiaojiang Xiao, Patompon Wongtrakoongate, Cecelia Trainor, Gary Felsenfeld   +3 more
doaj   +2 more sources

The tumor suppressor role of CTCF

Journal of Cellular Physiology, 2011
AbstractCTCF is an evolutionary conserved and ubiquitously expressed protein that binds thousands of sites in the human genome. Ectopic expression of CTCF in various normal and tumoral human cell lines inhibits cell division and clonogenicity, with the consequence to consider CTCF a potential tumor‐suppressor factor.
Fiorentino, Francesco Paolo, Giordano, Antonio   +1 more
openaire   +5 more sources

ADP-ribose polymers localized on Ctcf–Parp1–Dnmt1 complex prevent methylation of Ctcf target sites [PDF]

Biochemical Journal, 2011
PARylation [poly(ADP-ribosyl)ation] is involved in the maintenance of genomic methylation patterns through its control of Dnmt1 [DNA (cytosine-5)-methyltransferase 1] activity. Our previous findings indicated that Ctcf (CCCTC-binding factor) may be an important player in key events whereby PARylation controls the unmethylated status of some CpG-rich ...
ZAMPIERI, Michele, GUASTAFIERRO, Tiziana, CALABRESE, ROBERTA, CICCARONE, FABIO, BACALINI, MARIA GIULIA, REALE, Anna, Perilli M., Passananti C., CAIAFA, Paola   +8 more
openaire   +11 more sources

The structural basis for cohesin-CTCF-anchored loops

, 2020
Cohesin catalyses the folding of the genome into loops that are anchored by CTCF1. The molecular mechanism of how cohesin and CTCF structure the 3D genome has remained unclear. Here we show that a segment within the CTCF N terminus interacts with the SA2–
Marjon S van Ruiten (8549577), Angela Sedeno Cacciatore (8549571), Elzo de Wit (43946), Daniel Panne (7708598), Hans Teunissen (226813), Benjamin D Rowland (8549586), Yan Li (23143), Laureen Willems (8549580), Roel Oldenkamp (8549574), Judith HI Haarhuis (8549568), Kyle W Muir (8549583)   +10 more
core   +7 more sources

Histone Acetylation Differentially Modulates CTCF-CTCF Loops and Intra-TAD Interactions. [PDF]

Nat Commun
Abstract The cohesin complex structures the interphase genome of human cells by extruding loops and organizing topologically associating domains (TADs), yet how chromatin state regulates cohesin-chromatin interactions remains unclear.
Smith RG, Fu Y, Schiela KL, Dautle M, Williams RA, Wilson HM, Azadegan C, Whetstine JR, Dekker J, Liu Y.   +9 more
europepmc   +4 more sources

CTCF is a barrier for 2C-like reprogramming [PDF]

Nature Communications, 2021
AbstractTotipotent cells have the ability to generate embryonic and extra-embryonic tissues. Interestingly, a rare population of cells with totipotent-like potential, known as 2 cell (2C)-like cells, has been identified within ESC cultures. They arise from ESC and display similar features to those found in the 2C embryo.
Teresa Olbrich, Maria Vega-Sendino, Desiree Tillo, Wei Wu, Nicholas Zolnerowich, Raphael Pavani, Andy D. Tran, Catherine N. Domingo, Mariajose Franco, Marta Markiewicz-Potoczny, Gianluca Pegoraro, Peter C. FitzGerald, Michael J. Kruhlak, Eros Lazzerini-Denchi, Elphege P. Nora, André Nussenzweig, Sergio Ruiz   +16 more
openaire   +3 more sources

CTCF and cellular heterogeneity [PDF]

Cell & Bioscience, 2019
Abstract Cellular heterogeneity, which was initially defined for tumor cells, is a fundamental property of all cellular systems, ranging from genetic diversity to cell-to-cell variation driven by stochastic molecular interactions involved all cellular processes.
Gang Ren, Keji Zhao
openaire   +3 more sources