Results 11 to 20 of about 23,786 (199)
A Genome-wide Map of CTCF Multivalency Redefines the CTCF Code
Cell Reports, 2013 The “CTCF code” hypothesis posits that CTCF pleiotropic functions are driven by recognition of diverse sequences through combinatorial use of its 11 zinc fingers (ZFs).
Hirotaka Nakahashi +17 more
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CGGBP1 regulates CTCF occupancy at repeats
Epigenetics & Chromatin, 2019 Background CGGBP1 is a repeat-binding protein with diverse functions in the regulation of gene expression, cytosine methylation, repeat silencing and genomic integrity. CGGBP1 has also been identified as a cooperator of histone-modifying enzymes and as a
Divyesh Patel +3 more
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CTCF is a barrier for 2C-like reprogramming [PDF]
Nature Communications, 2021 AbstractTotipotent cells have the ability to generate embryonic and extra-embryonic tissues. Interestingly, a rare population of cells with totipotent-like potential, known as 2 cell (2C)-like cells, has been identified within ESC cultures. They arise from ESC and display similar features to those found in the 2C embryo.
Teresa Olbrich +16 more
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CTCF and cellular heterogeneity [PDF]
Cell & Bioscience, 2019 Abstract Cellular heterogeneity, which was initially defined for tumor cells, is a fundamental property of all cellular systems, ranging from genetic diversity to cell-to-cell variation driven by stochastic molecular interactions involved all cellular processes.
Gang Ren, Keji Zhao
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Predicting CTCF-mediated chromatin loops using CTCF-MP [PDF]
Bioinformatics, 2018 Abstract The three dimensional organization of chromosomes within the cell nucleus is highly regulated. It is known that CTCF is an important architectural protein to mediate long-range chromatin loops. Recent studies have shown that the majority of CTCF binding motif pairs at chromatin loop anchor regions are in convergent orientation.
Ruochi Zhang +4 more
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Current Opinion in Genetics & Development, 2020 CTCF plays a key role in organizing chromatin into TAD structures but it can also function as a transcription factor. CTCFL (CTCF-like), the paralog of CTCF, is normally transiently expressed in pre-meiotic male germ cells together with ubiquitously expressed CTCF.
Roxanne E, Debaugny, Jane A, Skok
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Spatial patterns of CTCF sites define the anatomy of TADs and their boundaries
Genome Biology, 2020 Background Topologically associating domains (TADs) are genomic regions of self-interaction. Additionally, it is known that TAD boundaries are enriched in CTCF binding sites.
Luca Nanni, Stefano Ceri, Colin Logie
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Heliyon, 2023 The most common reason for cancer-related death globally is predicted to be pancreatic cancer (PC), one of the deadliest cancers. The CCCTC-binding factor (CTCF) regulates the three-dimensional structure of chromatin, was reported to be highly regulated ...
Yihao Liu +9 more
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CTCF: Master Weaver of the Genome [PDF]
Cell, 2009 CTCF is a highly conserved zinc finger protein implicated in diverse regulatory functions, including transcriptional activation/repression, insulation, imprinting, and X chromosome inactivation. Here we re-evaluate data supporting these roles in the context of mechanistic insights provided by recent genome-wide studies and highlight evidence for CTCF ...
Phillips, Jennifer E., Corces, Victor G.
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CTCF terminal segments are unstructured [PDF]
Protein Science, 2010 AbstractThe human CCCTC‐binding factor, CTCF, organizes and regulates transcription of the genome by colocalizing distant DNA elements on the same and even different chromosomes. This protein consists of 11 zinc fingers flanked by polypeptide segments of unknown structure and function.
Selena R, Martinez, Jj L, Miranda
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