Results 11 to 20 of about 31,777 (224)

CGGBP1 regulates CTCF occupancy at repeats

Epigenetics & Chromatin, 2019
Background CGGBP1 is a repeat-binding protein with diverse functions in the regulation of gene expression, cytosine methylation, repeat silencing and genomic integrity. CGGBP1 has also been identified as a cooperator of histone-modifying enzymes and as a
Divyesh Patel, Manthan Patel, Subhamoy Datta, Umashankar Singh   +3 more
doaj   +4 more sources

Predicting CTCF-mediated chromatin loops using CTCF-MP [PDF]

Bioinformatics, 2018
The three dimensional organization of chromosomes within the cell nucleus is highly regulated. It is known that CTCF is an important architectural protein to mediate long-range chromatin loops.
Ruochi Zhang, Yuchuan Wang, Yang Zhang, Yang Yang, Jian Ma   +4 more
core   +4 more sources

A Genome-wide Map of CTCF Multivalency Redefines the CTCF Code

Cell Reports, 2013
The “CTCF code” hypothesis posits that CTCF pleiotropic functions are driven by recognition of diverse sequences through combinatorial use of its 11 zinc fingers (ZFs).
Hirotaka Nakahashi, Kyong-Rim Kieffer Kwon, Wolfgang Resch, Laura Vian, Marei Dose, Diana Stavreva, Ofir Hakim, Nathanael Pruett, Steevenson Nelson, Arito Yamane, Jason Qian, Wendy Dubois, Scott Welsh, Robert D. Phair, B. Franklin Pugh, Victor Lobanenkov, Gordon L. Hager, Rafael Casellas   +17 more
doaj   +3 more sources

ADP-ribose polymers localized on Ctcf-Parp1-Dnmt1 complex prevent methylation of Ctcf target sites [PDF]

Biochemical Journal, 2011
Poly(ADP-ribosyl)ation (PARylation) is involved in the maintenance of genomic methylation patterns through its control of DNA methyltranferase 1 (Dnmt1) activity.
Tiziana Guastafierro, Perilli, Mariagrazia, Roberta Calabrese, Maria G. Bacalini, GUASTAFIERRO, Tiziana, CICCARONE, FABIO, BACALINI, MARIA GIULIA, Paola Caiafa, M.G. Bacalini, CAIAFA, Paola, Claudio Passananti, Bacalini, Maria G., REALE, Anna, Passananti, Claudio, CALABRESE, ROBERTA, M. Perilli, Fabio Ciccarone, ZAMPIERI, Michele, Mariagrazia Perilli, Bacalini, Maria G, C. Passananti, Michele Zampieri, Anna Reale   +22 more
core   +11 more sources

CTCF Haploinsufficiency Destabilizes DNA Methylation and Predisposes to Cancer

Cell Reports, 2014
Epigenetic alterations, particularly in DNA methylation, are ubiquitous in cancer, yet the molecular origins and the consequences of these alterations are poorly understood.
Christopher J. Kemp, James M. Moore, Russell Moser, Brady Bernard, Matt Teater, Leslie E. Smith, Natalia A. Rabaia, Kay E. Gurley, Justin Guinney, Stephanie E. Busch, Rita Shaknovich, Victor V. Lobanenkov, Denny Liggitt, Ilya Shmulevich, Ari Melnick, Galina N. Filippova   +15 more
doaj   +2 more sources

CGGBP1-regulated cytosine methylation at CTCF-binding motifs resists stochasticity

BMC Genetics, 2020
Background The human CGGBP1 binds to GC-rich regions and interspersed repeats, maintains homeostasis of stochastic cytosine methylation and determines DNA-binding of CTCF.
Manthan Patel, Divyesh Patel, Subhamoy Datta, Umashankar Singh   +3 more
doaj   +2 more sources

NDFIP2 Suppresses Colorectal Cancer Metastasis Through DDX3X-Dependent R-Loop Remodeling and GNG13 Transcriptional Activation. [PDF]

Adv Sci (Weinh)
NDFIP2 recruits NEDD4 to promote K48‐linked ubiquitination and proteasomal degradation of DDX3X, leading to R‐loop accumulation and CTCF‐dependent suppression of GNG13 transcription. Consequently, PI3K/AKT signaling, EMT, stemness, and colorectal cancer metastasis are inhibited.
Zhang E, Li Y, Shu J, Xu S, Lv H, Zhang C, Zhang P, Wu N, Gong S, Zhang X, Ren Z, Liu X, Zhang Y.   +12 more
europepmc   +2 more sources

CTCF is a barrier for 2C-like reprogramming [PDF]

Nature Communications, 2021
AbstractTotipotent cells have the ability to generate embryonic and extra-embryonic tissues. Interestingly, a rare population of cells with totipotent-like potential, known as 2 cell (2C)-like cells, has been identified within ESC cultures. They arise from ESC and display similar features to those found in the 2C embryo.
Teresa Olbrich, Maria Vega-Sendino, Desiree Tillo, Wei Wu, Nicholas Zolnerowich, Raphael Pavani, Andy D. Tran, Catherine N. Domingo, Mariajose Franco, Marta Markiewicz-Potoczny, Gianluca Pegoraro, Peter C. FitzGerald, Michael J. Kruhlak, Eros Lazzerini-Denchi, Elphege P. Nora, André Nussenzweig, Sergio Ruiz   +16 more
openaire   +3 more sources

CTCF and cellular heterogeneity [PDF]

Cell & Bioscience, 2019
Abstract Cellular heterogeneity, which was initially defined for tumor cells, is a fundamental property of all cellular systems, ranging from genetic diversity to cell-to-cell variation driven by stochastic molecular interactions involved all cellular processes.
Gang Ren, Keji Zhao
openaire   +3 more sources

A YAP-TEAD-CTCF Transcriptional Regulatory Axis Associated With the Elimination of Injured Hepatocytes From the Liver. [PDF]

Genes Cells
Injured YAP‐activated hepatocytes are eliminated from the liver. They are extruded toward the sinusoidal lumen, undergo cell death, and are phagocytosed by macrophages. Here, we performed proximity ligation assay, ATAC‐seq, RNA‐seq, and CellChat analyses.
Hatakeyama D, Okamoto-Uchida Y, Kosaka M, Hirose H, Kofuji S, Danzaki K, Endo Y, Nakagawa M, Kanai A, Suzuki Y, Yokoo T, Terai S, Shimamura T, Nishina H.   +13 more
europepmc   +2 more sources