Results 31 to 40 of about 23,645 (194)
Modular insulators: genome wide search for composite CTCF/thyroid hormone receptor binding sites. [PDF]
PLoS ONE, 2010 The conserved 11 zinc-finger protein CTCF is involved in several transcriptional mechanisms, including insulation and enhancer blocking. We had previously identified two composite elements consisting of a CTCF and a TR binding site at the chicken ...
Oliver Weth +5 more
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Role of CTCF poly(ADP-Ribosyl)ation in the regulation of apoptosis in breast cancer cells
Indian Journal of Medical and Paediatric Oncology, 2015 Introduction: CTCF is a candidate tumor suppressor gene encoding a multifunctional transcription factor. CTCF function is controlled by posttranslational modification and interaction with other proteins. Research findings suggested that CTCF function can
Bhooma Venkatraman, Elena Klenova
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CTCF regulates the local epigenetic state of ribosomal DNA repeats
Epigenetics & Chromatin, 2010 Background CCCTC binding factor (CTCF) is a highly conserved zinc finger protein, which is involved in chromatin organization, local histone modifications, and RNA polymerase II-mediated gene transcription.
van de Nobelen Suzanne +14 more
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CTCF as a boundary factor for cohesin-mediated loop extrusion: evidence for a multi-step mechanism
Nucleus, 2020 Mammalian genome structure is closely linked to function. At the scale of kilobases to megabases, CTCF and cohesin organize the genome into chromatin loops.
Anders S. Hansen
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Nature Communications, 2021 Although the Drosophila genome has widespread contact domains and CTCF, it remains unclear whether CTCF-dependent domains exist in flies. Here, the authors ablate CTCF in Drosophila and find that CTCF is required to form a small fraction of all domain ...
Anjali Kaushal +16 more
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CTCF-mediated genome organization and leukemogenesis [PDF]
Leukemia, 2020 Recent technological advancements and genome-wide studies provide compelling evidence that dynamic chromatin interaction and three-dimensional genome organization in nuclei play an important role in regulating gene expression. Mammalian genomes consist of many small functional domains termed topologically associated domains (TADs), many of them ...
Yi Qiu, Suming Huang
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Functional and molecular characterization of the role of CTCF in human embryonic stem cell biology. [PDF]
PLoS ONE, 2012 The CCCTC-binding factor CTCF is the only known vertebrate insulator protein and has been shown to regulate important developmental processes such as imprinting, X-chromosome inactivation and genomic architecture.
Sri Kripa Balakrishnan +3 more
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Genomic Imprinting: CTCF Protects the Boundaries [PDF]
Current Biology, 2004 The DNA-binding protein CTCF, which acts as a chromatin 'insulator', regulates imprinting of the mammalian Igf2 and H19 genes in a methylation-sensitive manner. It has now been shown that CTCF is also required for protection against de novo methylation of the differentially methylated domain of H19 in the female germline.
Lewis, Annabelle, Murrell, Adele
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Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation
Genome Biology, 2020 Background The three-dimensional genome organization is critical for gene regulation and can malfunction in diseases like cancer. As a key regulator of genome organization, CCCTC-binding factor (CTCF) has been characterized as a DNA-binding protein with ...
Celestia Fang +14 more
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Acute depletion of CTCF rewires genome-wide chromatin accessibility
Genome Biology, 2021 Background The transcription factor CTCF appears indispensable in defining topologically associated domain boundaries and maintaining chromatin loop structures within these domains, supported by numerous functional studies.
Beisi Xu +12 more
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