Results 51 to 60 of about 31,777 (224)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Hyperosmotic stress induces rewiring of 3D chromatin interactions
Cell ReportsSummary: Cells continually face environmental stressors that challenge homeostasis, yet how three-dimensional (3D) chromatin structure contributes to these stress responses remains unclear under hyperosmotic conditions.
J.P. Flores +21 more
doaj +1 more source
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
CTCF regulates the local epigenetic state of ribosomal DNA repeats
Epigenetics & Chromatin, 2010 Background CCCTC binding factor (CTCF) is a highly conserved zinc finger protein, which is involved in chromatin organization, local histone modifications, and RNA polymerase II-mediated gene transcription.
van de Nobelen Suzanne +14 more
doaj +1 more source
Advanced Science, EarlyView.Using single‐cell transcriptomic and epigenomic profiling, researchers mapped microglial dysfunction across the lifespan of db/db mice. The authors uncovered a nonlinear microglial remodeling featuring early inflammatory priming, a mid‐stage transcriptional inflection, and late dysfunction.
Jizhou Zhang +6 more
wiley +1 more source
CTCF-binding sites are often mutated when acting as modulators of chromatin structure.
, 2016 CTCF-motifs are highly enriched inside loop anchor points and across domain boundaries (A, C). The number of substitutions in CTCF-motifs is increased for motifs that are located in loop anchor points (B); for domain boundaries, no significant increase ...
Martin S. Taylor (257588) +2 more
core +1 more source
An Artificial CTCF Peptide Triggers Efficient Therapeutic Efficacy in Ocular Melanoma
Molecular Therapy: Oncolytics, 2020 Although CCCTC binding factor (CTCF) has been demonstrated to play a variety of often contradictory roles in tumorigenesis, little is known about its function in the tumorigenesis of ocular melanoma. Here, we generated two artificial CTCF peptides (Decoy-
Xuyang Wen +9 more
doaj +1 more source
Advanced Science, EarlyView.A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung +15 more
wiley +1 more source
Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation
Genome Biology, 2020 Background The three-dimensional genome organization is critical for gene regulation and can malfunction in diseases like cancer. As a key regulator of genome organization, CCCTC-binding factor (CTCF) has been characterized as a DNA-binding protein with ...
Celestia Fang +14 more
doaj +1 more source
Functional and molecular characterization of the role of CTCF in human embryonic stem cell biology. [PDF]
PLoS ONE, 2012 The CCCTC-binding factor CTCF is the only known vertebrate insulator protein and has been shown to regulate important developmental processes such as imprinting, X-chromosome inactivation and genomic architecture.
Sri Kripa Balakrishnan +3 more
doaj +1 more source