Results 71 to 80 of about 29,893 (236)
Advanced Science, EarlyView.In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao +6 more
wiley +1 more source
CTCF physically links cohesin to chromatin [PDF]
Proceedings of the National Academy of Sciences, 2008 Cohesin is required to prevent premature dissociation of sister chromatids after DNA replication. Although its role in chromatid cohesion is well established, the functional significance of cohesin's association with interphase chromatin is not clear.
Eric D, Rubio +8 more
openaire +2 more sources
CTCF-binding sites and localization of XL9 inside the MHC-II locus.
, 2018 Schematic diagram showing the relative positions of MHC-II genes (grey shaded boxes) and CTCF binding sites (black ovals) on human chromosome 6p21.3 as identified by Majumder and Boss [20] with the XL9 region flanked by HLA-DRB1 and HLA-DQA1 (upper 2 ...
Christoph Arens (5746865) +6 more
core +1 more source
Friedreich ataxia patient tissues exhibit increased 5-hydroxymethylcytosine modification and decreased CTCF binding at the FXN locus [PDF]
, 2013 © 2013 Al-Mahdawi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use,distribution, and reproduction in any medium, provided the original author and source are ...
Pook, MA +11 more
core +1 more source
Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States
Advanced Science, EarlyView.Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton +13 more
wiley +1 more source
CTCF fences make good neighbours [PDF]
Nature Cell Biology, 2017 CCCTC-binding factor (CTCF) sites are enriched at the boundaries of topologically associated domains (TADs), but their function within TADs is unclear. Removal of sub-TAD CTCF sites adjacent to the α-globin enhancers is now shown to result in inappropriate activation of neighbouring genes.
Ivan, Krivega, Ann, Dean
openaire +2 more sources
, 2023 ChIA-PET data helps understand the proximity of sequences and their positions in a 3D structure, while CHIP-SEQ identifies sequences that specific proteins interact with.
Shihab Aldeen, Yanal
core
Epigenetic control of SPI1 gene by CTCF and ISWI ATPase SMARCA5.
PLoS ONE, 2014 CCCTC-binding factor (CTCF) can both activate as well as inhibit transcription by forming chromatin loops between regulatory regions and promoters. In this regard, Ctcf binding on non-methylated DNA and its interaction with the Cohesin complex results in
Martina Dluhosova +5 more
doaj +1 more source
A Novel Mechanism for CTCF in the Epigenetic Regulation of Bax in Breast Cancer Cells
Neoplasia: An International Journal for Oncology Research, 2013 We previously reported the association of elevated levels of the multifunctional transcription factor, CCCTC binding factor (CTCF), in breast cancer cells with the specific anti-apoptotic function of CTCF.
Claudia Fabiola Méndez-Catalá +10 more
doaj +1 more source
Advanced Science, EarlyView.A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung +15 more
wiley +1 more source