Results 71 to 80 of about 31,777 (224)

CTCF DNA-binding domain undergoes dynamic and selective protein–protein interactions

iScience, 2022
Summary: CTCF is a predominant insulator protein required for three-dimensional chromatin organization. However, the roles of its insulation of enhancers in a 3D nuclear organization have not been fully explained. Here, we found that the CTCF DNA-binding
Rong Zhou, Kai Tian, Jie Huang, Wenjia Duan, Hongye Fu, Ying Feng, Hui Wang, Yongpeng Jiang, Yuanjun Li, Rui Wang, Jiazhi Hu, Hanhui Ma, Zhi Qi, Xiong Ji   +13 more
doaj   +1 more source

CTCF physically links cohesin to chromatin [PDF]

Proceedings of the National Academy of Sciences, 2008
Cohesin is required to prevent premature dissociation of sister chromatids after DNA replication. Although its role in chromatid cohesion is well established, the functional significance of cohesin's association with interphase chromatin is not clear.
Eric D, Rubio, David J, Reiss, Piri L, Welcsh, Christine M, Disteche, Galina N, Filippova, Nitin S, Baliga, Ruedi, Aebersold, Jeffrey A, Ranish, Anton, Krumm   +8 more
openaire   +2 more sources

ZNF143 deletion alters enhancer/promoter looping and CTCF/cohesin geometry

Cell Reports
Summary: The transcription factor ZNF143 contains a central domain of seven zinc fingers in a tandem array and is involved in 3D genome construction. However, the mechanism by which ZNF143 functions in chromatin looping remains unclear.
Mo Zhang, Haiyan Huang, Jingwei Li, Qiang Wu   +3 more
doaj   +1 more source

TET-Catalyzed 5-Carboxylcytosine Promotes CTCF Binding to Suboptimal Sequences Genome-wide

iScience, 2019
Summary: The mechanisms supporting dynamic regulation of CTCF-binding sites remain poorly understood. Here we describe the TET-catalyzed 5-methylcytosine derivative, 5-carboxylcytosine (5caC), as a factor driving new CTCF binding within genomic DNA ...
Kyster K. Nanan, David M. Sturgill, Maria F. Prigge, Morgan Thenoz, Allissa A. Dillman, Mariana D. Mandler, Shalini Oberdoerffer   +6 more
doaj   +1 more source

Activation of oxidative stress-regulated Bcl-3 suppresses CTCF in corneal epithelial cells. [PDF]

PLoS ONE, 2011
Epigenetic factor CTCF (CCCTC binding factor) plays important roles in genetic controls of the cell fate. Previous studies found in corneal epithelial cells that CTCF is regulated by epidermal growth factor (EGF) through activation of NF-κB p65/p50.
Yumei Wang, Luo Lu
doaj   +1 more source

Rational Surface Engineering Reduces Advanced Glycation End‐Product Adsorption and Improves Implant Integration

Advanced Science, EarlyView.
Targeted surface chemical modification prevents the accumulation of advanced glycation end products (AGEs) on implant surfaces, attenuates inflammation and fibrosis, effectively restores angiogenic activity, and improves osseointegration under diabetic conditions.
Thien Ngoc Le, Wenhao Chen, Tengxiao Huang, Tien Thanh Nguyen, Markos Negash Alemie, Xuan Duy Do, Giles Best, Jordan Li, Jitraporn Vongsvivut, Vi‐Khanh Truong, Weiwei Li, Yunpeng Zhao, Richard Bright, Krasimir Vasilev   +13 more
wiley   +1 more source

CTCF, Cohesin, and Chromatin in Human Cancer [PDF]

Genomics & Informatics, 2017
It is becoming increasingly clear that eukaryotic genomes are subjected to higher-order chromatin organization by the CCCTC-binding factor/cohesin complex. Their dynamic interactions in three dimensions within the nucleus regulate gene transcription by changing the chromatin architecture.
Sang-Hyun Song, Tae-You Kim
openaire   +3 more sources

Chromium disrupts chromatin organization and CTCF access to its cognate sites in promoters of differentially expressed genes

Epigenetics, 2018
Hexavalent chromium compounds are well-established respiratory carcinogens used in industrial processes. While inhalation exposure constitutes an occupational risk affecting mostly chromium workers, environmental exposure from drinking water is a ...
Andrew VonHandorf, Francisco Javier Sánchez-Martín, Jacek Biesiada, Hongxia Zhang, Xiang Zhang, Mario Medvedovic, Alvaro Puga   +6 more
doaj   +1 more source

STRIDE: A Sequencing Depth Robust Metric for Sparse Chromosome Conformation Capture Data Comparison

Advanced Science, EarlyView.
A mean first passage time (MFPT)‐based representation transforms sparse Hi‐C contact maps into robust topological representations, preserving biologically meaningful chromatin features and facilitating robust analysis of TADs, chromatin loops, differential chromatin contacts, and sparse single‐cell Hi‐C data.
Bingxiang Xu, Xiaomeng Gao, Weichu Tao, Zhihua Zhang, Feifei Li   +4 more
wiley   +1 more source

Ctcf and Smarca5 interact in AML cells.

, 2014
A Ctcf occupancy at ICR. ChIP of Ctcf-siRNA-treated MEL cells (Ctcf siRNA, black bars) or non-specific siRNA (Ctrl siRNA, white) at 72 hrs. Y-axis: specific IP DNA fragment enrichment over control IP (standard error, SE).
Nikola Curik (519145), Martina Dluhosova (519144), Jarmila Vargova (519146), Anna Jonasova (519147), Tomas Stopka (519149), Tomas Zikmund (519148)   +5 more
core   +1 more source