Results 91 to 100 of about 29,893 (236)

An alternative CTCF isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis [PDF]

Nature Communications, 2019
AbstractCTCF plays key roles in gene regulation, chromatin insulation, imprinting, X chromosome inactivation and organizing the higher-order chromatin architecture of mammalian genomes. Previous studies have mainly focused on the roles of the canonical CTCF isoform.
Jiao Li, Kaimeng Huang, Gongcheng Hu, Isaac A. Babarinde, Yaoyi Li, Xiaotao Dong, Yu-Sheng Chen, Liping Shang, Wenjing Guo, Junwei Wang, Zhaoming Chen, Andrew P. Hutchins, Yun-Gui Yang, Hongjie Yao   +13 more
openaire   +3 more sources

Early‐Life Telomere Length Negatively Covaries With Brood Size and Father Age, and Predicts Long‐Term Survival in Male Barn Swallows (Hirundo rustica)

Integrative Zoology, EarlyView.
In barn swallows, nestlings raised in larger broods or by older social fathers have shorter telomeres, and those with longer telomeres tend to live longer, suggesting that early‐life conditions may shape individual lifespan through telomere dynamics. ABSTRACT Parental decisions on breeding, such as brood size and timing of reproduction, influence the ...
Andrea Novelli, Manuela Caprioli, Roberto Ambrosini, Alessandra Costanzo, Diego Rubolini, Marco Parolini, Andrea Romano   +6 more
wiley   +1 more source

CTCF analysis.

, 2013
(A) EMSA showing a mobility shift for the FXN 5’ UTR probe and CTCF-positive DM1 (1) probe [35], while there is no such shift detected for the FXN upstream GAA (Up) probe, FXN downstream GAA (Down) probe or CTCF-negative DM1 (3) probe [35].
Chiranjeevi Sandi (283956), Ricardo Mouro Pinto (207712), Mark A. Pook (126056), Sahar Al-Mahdawi (126054)   +3 more
core   +1 more source

Supporting data for GM12878 CTCF HiCuT.

, 2022
(A) Scatter Plot correlation of aligned reads from HiCuT replicates. Spearman r is indicated. (B) Genome browser snapshot showing GM12878 CTCF HiCuT tracks (red), CTCF CUT&RUN Tracks from 4DN Network (green, 4DNES6GVE8XZ) and CTCF ChIP-Seq tracks from ...
Parker Jones (12280464), Emmanuel Rapp-Reyes (12280473), Satish Sati (184209), Linda A. Zhou (12280470), Hali S. Kim (12280467), Thomas H. Leung (12280476)   +5 more
core   +1 more source

CGGBP1-regulated cytosine methylation at CTCF-binding motifs resists stochasticity

BMC Genetics, 2020
Background The human CGGBP1 binds to GC-rich regions and interspersed repeats, maintains homeostasis of stochastic cytosine methylation and determines DNA-binding of CTCF.
Manthan Patel, Divyesh Patel, Subhamoy Datta, Umashankar Singh   +3 more
doaj   +1 more source

The Functional Role and Molecular Characterization of the Therapeutic Target CLDN6 in Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The tight junction protein CLDN6 has been identified as a cancer‐associated cell surface marker that is rarely expressed in healthy tissues. In testicular germ cell tumors (GCT), CLDN6 is particularly detectable in seminomas, embryonal carcinomas, and choriocarcinomas.
Jule Zwick, Margaretha A. Skowron, Gereon Poschmann, Patrick Petzsch, Ann Kathrin Bergmann, Kai Stühler, Jochen Hecht, Daniel Nettersheim   +7 more
wiley   +1 more source

A functional analysis of the epigenetic regulator CTCF [PDF]

, 2010
The highly conserved protein CTCF (CCCTC-binding factor) participates in many epigenetic regulatory functions, including insulation, imprinting, X chromosome inactivation, and both transcriptional activation and repression. Recent data has also suggested
Kitchen, Neal S.
core  

DNA methylation insulates genic regions from CTCF loops near nuclear speckles

eLife
The insulator protein CTCF is essential for mediating chromatin loops and regulating gene expression. While it is established that DNA methylation hinders CTCF binding, the impacts of this methylation-sensitive CTCF binding on chromatin architecture and ...
Shelby A Roseman, Allison P Siegenfeld, Ceejay Lee, Nicholas Z Lue, Amanda L Waterbury, Brian B Liau   +5 more
doaj   +1 more source

MEN1 Deficiency Drives Lung Cancer Progression via Activation of MMP10‐Mediated Angiogenesis

Cancer Science, EarlyView.
MEN1 deficiency promotes JunD‐mediated upregulation of MMP10 expression, which cleaves pro‐HB‐EGF and activates endothelial EGFR. This triggers the PI3K/Akt and MEK/ERK signaling pathways, thereby driving angiogenesis and tumor progression. MMP10 inhibitor treatment blocks this cleavage, suppresses EGFR signaling, and thereby delays malignant ...
Chengyu Wei, Xiangyu Liu, Shimin Hu, Xiaodie Shen, Yingli Liu, Xinxin Qin, Ye Zhou, Jianqi Zheng, Bingke Tian, Jingfang Hong, Yongxia Song, Di Wang, Linlin Peng, Jinxia Ding, Fang Wang, Hui Zhang, Shihao Zhang, Huan Qiu   +17 more
wiley   +1 more source

Variants in the Imprinted IGF2 Gene: A Review and Phasing of De Novo Variants Using Long‐Read Sequencing

Clinical Genetics, EarlyView.
Pathogenic IGF2 variants on the paternal allele can cause Silver–Russell syndrome, with highly variable growth and neurodevelopmental outcomes. Long‐read sequencing can determine the parental origin of de novo IGF2 variants via methylation patterns without parental samples, improving diagnostics for imprinted genes.
Trine Maxel Juul, Susanne Eriksen Boonen, Katja Venborg Pedersen, Caroline Hey Bækgaard, Martin Larsen, Maria Kibæk, Niels Illum, Malene Heideman, Christiane Nielsen, Emilie Boye Lester, Christina Fagerberg   +10 more
wiley   +1 more source