Results 91 to 100 of about 23,645 (194)

Regulation of cholesterol biosynthesis by CTCF and H3K27 methylation is critical for cell migration

European Journal of Cell Biology
CTCF is a key factor in three-dimensional chromatin folding and transcriptional control that was found to affect cancer cell migration by a mechanism that is still poorly understood. To identify this mechanism, we used mouse melanoma cells with a partial
Lukasz Stanislaw Kaczmarczyk, Dagmawit Babele, Nehora Levi, Gowthaman Gunasekaran, Mali Salmon-Divon, Gabi Gerlitz   +5 more
doaj   +1 more source

CTCF genomic binding sites in Drosophila and the organisation of the bithorax complex.

PLoS Genetics, 2007
Insulator or enhancer-blocking elements are proposed to play an important role in the regulation of transcription by preventing inappropriate enhancer/promoter interaction.
Eimear E Holohan, Camilla Kwong, Boris Adryan, Marek Bartkuhn, Martin Herold, Rainer Renkawitz, Steven Russell, Robert White   +7 more
doaj   +1 more source

Therapeutic Peptide SS‐31 Modulates Membrane Binding and Aggregation of α‐Synuclein and Restores Impaired Mitochondrial Function

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
SS‐31 (Elamipretide) inhibits α‐synuclein aggregation on the membranes and emerges as a promising therapeutic candidate against mitochondrial dysfunction in Parkinson's disease. ABSTRACT Membrane binding and aggregation properties of α‐synuclein are closely associated with Parkinson's disease and a class of related syndromes named as synucleinopathy ...
Ewelina Stefaniak, Beiyuan Cui, Xucheng Yan, Kexin Sun, Xiangyu Teng, Liming Ying   +5 more
wiley   +1 more source

Exploration of CTCF post-translation modifications uncovers Serine-224 phosphorylation by PLK1 at pericentric regions during the G2/M transition

eLife, 2019
The zinc finger CCCTC-binding protein (CTCF) carries out many functions in the cell. Although previous studies sought to explain CTCF multivalency based on sequence composition of binding sites, few examined how CTCF post-translational modification (PTM)
Brian C Del Rosario, Andrea J Kriz, Amanda M Del Rosario, Anthony Anselmo, Christopher J Fry, Forest M White, Ruslan I Sadreyev, Jeannie T Lee   +7 more
doaj   +1 more source

Copy Number Variants in the 11p15.5 Associated Imprinting Disorders: An Attempt to Establish a Genotype–Phenotype Correlation

Clinical Genetics, Volume 109, Issue 6, Page 999-1006, June 2026.
Copy number variations (CNVs) in 11p15.5 account for more than 2% of the molecular disturbances in the imprinting disorders Beckwith–Wiedemann and Silver–Russell syndrome. Their size and gene content vary, and therefore the impact on the phenotype is variable. Based on published data from > 220 carriers, an overview of the pathogenicity of 11p15.5 CNVs
Anastasia Maria Licata, Elke Botzenhart, Katja Kloth‐Stachnau, Thomas Eggermann   +3 more
wiley   +1 more source

Histone Acetylation Differentially Modulates CTCF-CTCF Loops and Intra-TAD Interactions

Abstract The cohesin complex structures the interphase genome by extruding loops and organizing topologically associating domains (TADs). While cohesin engages chromatin in context- dependent modes, the regulatory influence of chromatin state on these interactions remains unclear.
Smith, Rebecca G, Fu, Yu, Schiela, Kathleen L, Dautle, Madison, Williams, Ryan, Wilson, Hannah M, Azadegan, Chloe, Whetstine, Johnathan R, Dekker, Job, Liu, Yu   +9 more
openaire   +3 more sources

Significance of Myelodysplasia‐Related Mutations and the Genetic Landscape of Acute Leukemias of Ambiguous Lineage

International Journal of Laboratory Hematology, Volume 48, Issue 3, Page 512-520, June 2026.
ABSTRACT The recent fifth edition WHO classification and ICC classification systems have moved further toward genetically defined classifications of acute leukemias. Both now recognize myelodysplasia‐related (MR) mutations as defining of MDS‐related AML (AML‐MR).
Timothy J. Kirtek, Olga K. Weinberg
wiley   +1 more source

Advances in Visualizing Cytosine Methylation and Allele‐Specific Epigenetic States in Tissue Context

Pathology International, Volume 76, Issue 6, June 2026.
The ICON method enables sequence‐specific, bisulfite‐free visualization of DNA methylation through chemical recognition of methylated cytosines. Following probe hybridization under mild denaturing conditions, methylation‐dependent interstrand complexes are stabilized by covalent crosslinking.
Sohei Kitazawa, Ryuma Haraguchi, Riko Kitazawa   +2 more
wiley   +1 more source

Genomic Landscape Analysis of Canine Pulmonary Adenocarcinoma Reveals Candidate Targetable Gene Fusions

Veterinary and Comparative Oncology, Volume 24, Issue 2, Page 393-406, June 2026.
ABSTRACT Spontaneously occurring primary canine pulmonary adenocarcinoma (cPAC) exhibits clinicopathological and molecular similarities to never‐smoker human lung cancers. Shared genomic alterations, including point mutations, indel mutations and copy number changes particularly in HER2 signalling, are significant therapeutic targets, especially for ...
Sharadha Sakthikumar, William P. D. Hendricks, David Rainford, William Selleck, Natalia Briones, Christopher Coggins, Natalie Quan, Victoria Zismann, Gwendolen Lorch, Aleksandar Sekulic, Jeffrey M. Trent   +10 more
wiley   +1 more source

CTCF binding landscape in jawless fish with reference to Hox cluster evolution

Scientific Reports, 2017
The nuclear protein CCCTC-binding factor (CTCF) contributes as an insulator to chromatin organization in animal genomes. Currently, our knowledge of its binding property is confined mainly to mammals.
Mitsutaka Kadota, Yuichiro Hara, Kaori Tanaka, Wataru Takagi, Chiharu Tanegashima, Osamu Nishimura, Shigehiro Kuraku   +6 more
doaj   +1 more source