Results 101 to 110 of about 31,777 (224)
, 2012 (a) Of the eleven zincfingers in CTCF, only four are required for strong binding. The orientation of the binding with respect to the CTCF motif was determined by Renda et al [23]. (b) The dominant orientation of the CTCF/H2A.Z pattern with respect to the
Rune Møllegaard Friborg (189363) +5 more
core +1 more source
TOP1MT rs2293925 is an enhancer‐active regulatory SNP that shapes mitochondrial R‐loop dynamics
The FEBS Journal, EarlyView.This study shows how a common genetic variant of mitochondrial topoisomerase 1 (TOP1MT rs2293925) can influence mitochondrial gene regulation, DNA topology, and formation of noncanonical nucleic acid structures such as R‐loops. By linking this enhancer‐active variant to mitochondrial nucleic acid stress in cellular contexts relevant to amyotrophic ...
Dóra Varga +15 more
wiley +1 more source
, 2014 First: The reverse complement of the known CTCF motif from the JASPAR database (MA0139.1). Second: The motif recovered by STEME using the shuffled control sequences. STEME also recovers a near identical motif using the promoter control sequences.
John E. Reid (535008) +1 more
core +1 more source
Genome‐Wide Association Studies for Anogenital Distance and Linear Type Traits in Gir Cattle
Journal of Animal Breeding and Genetics, EarlyView.ABSTRACT Although linear type traits have been under selection in the Dairy Gir cattle for the past three decades, there are few studies exploring genetic architecture for these traits. The aim of this study was to identify candidate genes for anogenital distance and linear type traits in the Gir breed. For this study, the body measures of rump length (
Renata de Fátima Bretanha Rocha +8 more
wiley +1 more source
Effect of CTCF depletion on KSHV virion production.
, 2014 A. CTCF knockdown in iSLK cells. Cells were transfected with either negative control siRNA (NC Si) or siRNA specific for CTCF (CTCF Si). Cell lysates were prepared 48 h after transfection and analyzed by immunoblotting with an anti-CTCF antibody (upper ...
Da-Jiang Li (507793) +3 more
core +1 more source
The LDB1 Complex Co-opts CTCF for Erythroid Lineage-Specific Long-Range Enhancer Interactions
Cell Reports, 2017 Summary: Lineage-specific transcription factors are critical for long-range enhancer interactions, but direct or indirect contributions of architectural proteins such as CCCTC-binding factor (CTCF) to enhancer function remain less clear. The LDB1 complex
Jongjoo Lee +3 more
doaj +1 more source
Journal of Integrative Plant Biology, EarlyView.This review decodes the grammar of plant cis‐regulatory elements, revealing that their function emerges from sequence, chromatin accessibility, 3D topology, and cell type context. It highlights how single‐cell omics, CRISPR dissection, and AI‐driven design converge to enable predictive engineering and crop improvement. ABSTRACT Cis‐regulatory elements (
Libin Zhang, Maoteng Li
wiley +1 more source
Ctcf haploinsufficiency mediates intron retention in a tissue-specific manner [PDF]
, 2020 CTCF is a master regulator of gene transcription and chromatin organisation with occupancy at thousands of DNA target sites genome-wide. While CTCF is essential for cell survival, CTCF haploinsufficiency is associated with tumour development and ...
Marshall, Amy D. +8 more
core
Potential Role of CTCF in Differential Papillomavirus Gene Expression
, 2009 Upon cellular differentiation the late genes of the Human Papillomavirus (HPV) are expressed. Recently, the CTCF DNA-binding protein has been found to be transcription factor and chromatin insulator.
Talbot, Alyson P.
core +3 more sources
CTCF genomic binding sites in Drosophila and the organisation of the bithorax complex.
PLoS Genetics, 2007 Insulator or enhancer-blocking elements are proposed to play an important role in the regulation of transcription by preventing inappropriate enhancer/promoter interaction.
Eimear E Holohan +7 more
doaj +1 more source