Results 111 to 120 of about 31,777 (224)

Trafficking and potentiation of Nav1.7 and Nav1.8 channels are mediated by IQGAP1

The Journal of Physiology, EarlyView.
Abstract figure legend IQGAP1 binds to the voltage‐gated Nav1.7 and Nav1.8 channels and TRPA1 channels in sensory neurons. Inflammatory mediators (IM), including PGE2 and TNFα, released during nerve injury and inflammation activate intracellular signalling messengers such as PKA, p38 MAPK and Cdc42 through their respective receptors.
Xuming Zhang, Pabitra Hriday Patra, Jinquan Yang   +2 more
wiley   +1 more source

Additional file 3: Fig. S3. of Comparative analyses of CTCF and BORIS occupancies uncover two distinct classes of CTCF binding genomic regions

, 2016
EMSA demonstrates the presence of two CTCF binding sites inside BORIS bound regions (CTCF&BORIS and BORIS-only). a Top panels: ChIP-seq tracks show CTCF and BORIS occupancies mapped in K562, Delta47 and NHDF cells.
Claudia Méndez-Catalá (3563165), John Rasko (3563159), Bing Ren (78555), Teruhiko Suzuki (238004), Dmitri Loukinov (12908), Samuel Rivero-Hinojosa (3563156), Abdelhalim Boukaba (273491), Sungyun Kang (3563150), Celso Espinoza (3563153), Alexander Strunnikov (260505), Susan Robinson (337982), Victor Lobanenkov (12910), Natsuki Kosaka-Suzuki (238006), Elena Pugacheva (171978), Vijayaraj Nagarajan (37149), Zhen Ye (411620)   +15 more
core   +1 more source

Regulation of cholesterol biosynthesis by CTCF and H3K27 methylation is critical for cell migration

European Journal of Cell Biology
CTCF is a key factor in three-dimensional chromatin folding and transcriptional control that was found to affect cancer cell migration by a mechanism that is still poorly understood. To identify this mechanism, we used mouse melanoma cells with a partial
Lukasz Stanislaw Kaczmarczyk, Dagmawit Babele, Nehora Levi, Gowthaman Gunasekaran, Mali Salmon-Divon, Gabi Gerlitz   +5 more
doaj   +1 more source

Acute mechanical stretch enhances β‐adrenergic–protein kinase A signalling and increases susceptibility to ventricular arrhythmias

The Journal of Physiology, EarlyView.
Abstract figure legend Mechanical stretch alters Cav3‐associated membrane organisation and enhances β‐adrenergic receptor (βAR)–protein kinase A (PKA)‐dependent Ca2+ instability. Schematic overview of the experimental strategy and proposed mechanism: rat hearts were studied by Langendorff optical mapping using a fluid‐filled left ventricular (LV ...
Houcheng Wang, En‐Chi Lai, Zhen Hua, Chenyu Liu, Ivan Sherstnev, Jiarong Fu, Fu Siong Ng, Julia Gorelik   +7 more
wiley   +1 more source

Warburg redefined: Metabolites, mitochondria and macrophages in immune regulation

The Journal of Physiology, EarlyView.
Abstract figure legend Following pro‐inflammatory stimulation, macrophages undergo Warburg‐like metabolic rewiring that extends more than increased glycolysis. The non‐canonical functions of glycolytic enzymes and lactate accumulation control macrophage immune responses through multiple signalling pathways (a).
Yukun Min, Órlaith C. Henry, Luke A. J. O'Neill   +2 more
wiley   +1 more source

CTCF-RNA interactions orchestrate cell-specific chromatin loop organization

CCCTC-binding factor (CTCF) is essential for chromatin organization. CTCF interacts with endogenous RNAs, and deletion of its ZF1 RNA binding region (∆ZF1) disrupts chromatin loops in mouse embryonic stem cells (ESCs).
Mazzoni, Esteban O, Reinberg, Danny, Qiu, Xiang, Lucero, Kimberly, Huang, Pin-Yao, Han, Sungwook   +5 more
core   +2 more sources

Cross‐Regulation Between DNA Methylation and Circadian Clock Reprogramming in Ovarian Cancer: Mechanistic Insights, Biomarker Potential, and Therapeutic Implications

International Journal of Cancer, Volume 160, Issue 1, Page 7-23, 1 January 2027.
ABSTRACT Early diagnosis remains challenging, recurrence rates remain high, and platinum resistance frequently develops in ovarian cancer (OC), collectively representing major barriers to long‐term patient survival. DNA methylation (DNAm), as a relatively stable yet dynamically modifiable epigenetic signature, can capture alterations in tumor states ...
Min Xing, Chang Zhou, Yi Tang, Shuhui Xu, Shasha Zhou, Weiai Liu, Huiping Liu   +6 more
wiley   +1 more source

Sex‐Modulated TACSTD2 Methylation and Hormone‐Receptor Axis Interactions in Glioblastoma: Insights Toward Mechanistic Understanding

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
Sex‐stratified analyses of the TCGA and CGGA cohorts have identified promoter‐proximal TACSTD2 CpG sites where methylation shows opposite survival associations in males and females, is independent of copy number, and correlates with TACSTD2 expression.
Tahreem Fatima
wiley   +1 more source

Identifizierung und Analyse von Protein-Interaktionspartnern des Isolationsfaktors CTCF [PDF]

, 2011
CTCF ist ein multivalenter Faktor, der in eine Reihe von Regulationsvorgängen involviert ist. Im Mittelpunkt der vorliegenden Arbeit standen Untersuchungen zu seiner Fähigkeit, Chromatin-Isolation zu vermitteln.
Panzer, Imke
core   +1 more source

Variants in the Imprinted IGF2 Gene: A Review and Phasing of De Novo Variants Using Long‐Read Sequencing

Clinical Genetics, Volume 110, Issue 6, Page 748-755, December 2026.
Pathogenic IGF2 variants on the paternal allele can cause Silver–Russell syndrome, with highly variable growth and neurodevelopmental outcomes. Long‐read sequencing can determine the parental origin of de novo IGF2 variants via methylation patterns without parental samples, improving diagnostics for imprinted genes.
Trine Maxel Juul, Susanne Eriksen Boonen, Katja Venborg Pedersen, Caroline Hey Bækgaard, Martin Larsen, Maria Kibæk, Niels Illum, Malene Heideman, Christiane Nielsen, Emilie Boye Lester, Christina Fagerberg   +10 more
wiley   +1 more source