Results 111 to 120 of about 29,893 (236)
The LDB1 Complex Co-opts CTCF for Erythroid Lineage-Specific Long-Range Enhancer Interactions
Cell Reports, 2017 Summary: Lineage-specific transcription factors are critical for long-range enhancer interactions, but direct or indirect contributions of architectural proteins such as CCCTC-binding factor (CTCF) to enhancer function remain less clear. The LDB1 complex
Jongjoo Lee +3 more
doaj +1 more source
Journal of Integrative Plant Biology, EarlyView.This review decodes the grammar of plant cis‐regulatory elements, revealing that their function emerges from sequence, chromatin accessibility, 3D topology, and cell type context. It highlights how single‐cell omics, CRISPR dissection, and AI‐driven design converge to enable predictive engineering and crop improvement. ABSTRACT Cis‐regulatory elements (
Libin Zhang, Maoteng Li
wiley +1 more source
Trafficking and potentiation of Nav1.7 and Nav1.8 channels are mediated by IQGAP1
The Journal of Physiology, EarlyView.Abstract figure legend IQGAP1 binds to the voltage‐gated Nav1.7 and Nav1.8 channels and TRPA1 channels in sensory neurons. Inflammatory mediators (IM), including PGE2 and TNFα, released during nerve injury and inflammation activate intracellular signalling messengers such as PKA, p38 MAPK and Cdc42 through their respective receptors.
Xuming Zhang +2 more
wiley +1 more source
Computational and Systems Oncology, Volume 6, Issue 1, December 2026.Sex‐stratified analyses of the TCGA and CGGA cohorts have identified promoter‐proximal TACSTD2 CpG sites where methylation shows opposite survival associations in males and females, is independent of copy number, and correlates with TACSTD2 expression.
Tahreem Fatima
wiley +1 more source
Untangling Mechanisms of the Architectural Protein CTCF [PDF]
, 2018 The three-dimensional structure of chromatin regulates gene expression by facilitating contacts between promoters and regulatory elements, demarcating regions of activity and repression and compartmentalising the genome into Topologically Associating ...
Khoury, Amanda
core +1 more source
Exploring Interactive Effects of Arsenic and Selenium Exposure on Larval Zebrafish (Danio rerio)
Environmental Toxicology, Volume 41, Issue 10, Page 1027-1040, October 2026.ABSTRACT Arsenic contamination in aquatic ecosystems is a major environmental concern. Selenium (Se) helps mitigate oxidative stress and hence could reduce the toxic effects of arsenic. However, Se can also be toxic at high concentrations. Given that these metalloids commonly co‐occur in the environment, there is a pressing need for further research ...
Owen Luo +6 more
wiley +1 more source
Chromatin features of CTCF-binding sites.
, 2012 (A) Open chromatin proximal to CTCF-binding sites in K562 cells. DNaseI HS, DNaseI DGF, and FAIRE profiles of cell type-specific (left), common (middle), and ubiquitous (right) CTCF-binding sites.
Shengqi Wang (13970) +4 more
core +1 more source
New Phytologist, Volume 252, Issue 1, Page 178-191, October 2026.Characterization of periclinal and anticlinal cell divisions in dividing cambium stem cells (CSCs). (a) Scheme indicating periclinal and anticlinal cell divisions in CSCs in the Arabidopsis hypocotyl. The orange dashed ring in the middle panel represents the cambium area. The orange cuboids represent individual CSCs.
Xiaomin Liu +4 more
wiley +1 more source
CTCF genomic binding sites in Drosophila and the organisation of the bithorax complex.
PLoS Genetics, 2007 Insulator or enhancer-blocking elements are proposed to play an important role in the regulation of transcription by preventing inappropriate enhancer/promoter interaction.
Eimear E Holohan +7 more
doaj +1 more source