Results 131 to 140 of about 31,777 (224)

CTCF Expression is Essential for Somatic Cell Viability and Protection Against Cancer

, 2018
CCCTC-binding factor (CTCF) is a conserved transcription factor that performs diverse roles in transcriptional regulation and chromatin architecture. Cancer genome sequencing reveals diverse acquired mutations in CTCF, which we have shown functions as a ...
Yue Feng, John EJ Rasko, Crystal Semaan, Charles G Bailey, Kinsha Baidya, Cynthia Metierre, Victor V Lobanenkov, Dmitri I Loukinov, Galina N Filippova   +8 more
core   +1 more source

The insulator factor CTCF prevents spreading of aberrant methylation.

, 2013
(A) Methylation heterogeneity depends on the density of CTCF-binding sites. Methylation state (M-score, left) and inter-sample methylation variation (IQR, right) are shown for CTCF-BS-poor, CTCF-BS-rich, and intermediate regions.
Huimin Geng (103831), Ari Melnick (88754), Franziska Michor (103841), Jose M. Polo (103836), Markus Riester (79808), Matthias Kormaksson (103832), Rita Shaknovich (103829), Olivier Elemento (7617), Bruce Woolcock (103834), Subhajyoti De (46970), Yanwen Jiang (103833), Nathalie Johnson (103835), Leandro Cerchietti (103837), Randy D. Gascoyne (103838)   +13 more
core   +1 more source

Functional analysis of CTCF during mammalian limb development

, 2010
SummaryCCCTC-binding factor (CTCF) is a nuclear zinc-finger protein that displays insulating activity in a variety of biological assays. For example, CTCF-binding sites have been suggested to isolate Hox gene clusters from neighboring transcriptional ...
Duboule, Denis, Leleu, Marion, Marion Leleu, Soshnikova, Natalia, Leleu, M, Thomas Montavon, Natalia Soshnikova, Denis Duboule, Duboule, D, Galjart, Niels; id_orcid, Soshnikova, N, Galjart, Niels, Niels Galjart, Montavon, Thomas, Montavon, T, Montavon T, Galjart N, Leleu M, Soshnikova N, Duboule D   +19 more
core   +1 more source

Characterization of the molecular interactions between Kaiso and CTCF using AlphaFold2 and molecular dynamics simulations

Bibechana
CCCTC-binding factor (CTCF) is an architectural protein that plays a crucial role in global chromatin organization and remodeling via its interaction with several protein partners.
Bidhya Thapa, Narayan Prasad Adhikari
doaj   +1 more source

An upstream secondary DNA motif within the IL3 insulator CTCF binding site is required for enhancer-blocking insulator activity.

PLoS ONE
CCCTC-binding Factor (CTCF) is the only known vertebrate protein that functions to organise the genome into distinct functional chromatin domains. A subset of CTCF sites also provide insulator activity and barrier activity to block inappropriate enhancer-
Sarion R Bowers, Peter N Cockerill
doaj   +1 more source

PDS5A and TOP2B cooperate for chromatin recruitment via CTCF. [PDF]

Sci Adv
Gonzalez-Buendia E, Ortabozkoyun H, Reinberg D.   +2 more
europepmc   +1 more source

Chromatin rewiring in endothelial cells upon cohesin reduction redistributes genome-wide FLI1 binding. [PDF]

Epigenetics
Ray A, Pandey R, Chrisenberry DB, Murray JD, Stelloh C, Liu P, Liu Y, Qiu Q, Meyer AE, Tutaj M, Lin CW, Kasomva K, Sadowski M, Auer P, Widlansky ME, Geurts AM, Cowley AW, Kwitek AE, Greene AS, Liang M, Rao S.   +20 more
europepmc   +1 more source

Lamin A regulates chromatin structure and function in cardiac myocytes in a mouse model of lamin-cardiomyopathy. [PDF]

NAR Mol Med
Gurha P, Wang W, Cathcart B, Rouhi L, Marian AJ.   +4 more
europepmc   +1 more source

Leveraging human-trained neural networks for cross-species chromatin regulation annotations. [PDF]

G3 (Bethesda)
Maillard N, Demars J, Mourad R.
europepmc   +1 more source

Transcriptional Repressor CTCF [PDF]

, 2020
openaire   +1 more source