British Journal of Pharmacology, Volume 183, Issue 17, Page 5355-5371, September 2026.Abstract Background and Purpose We hypothesised that dual priming of human bone marrow‐derived human mesenchymal stem cells (hBMSCs) with interleukin‐1alpha (IL‐1α) and CoCl2 (a hypoxia mimetic) would modulate their therapeutic efficacy for hypoxic‐ischaemic conditions. Experimental Approach hBMSCs were primed individually or in combination.
Maryam Adenike Salaudeen +2 more
wiley +1 more source
Ctcf and Smarca5 interact in AML cells.
, 2014 A Ctcf occupancy at ICR. ChIP of Ctcf-siRNA-treated MEL cells (Ctcf siRNA, black bars) or non-specific siRNA (Ctrl siRNA, white) at 72 hrs. Y-axis: specific IP DNA fragment enrichment over control IP (standard error, SE).
Nikola Curik (519145) +5 more
core +1 more source
Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders
The FEBS Journal, Volume 293, Issue 17, Page 5149-5169, September 2026.Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo +6 more
wiley +1 more source
CTCF binding landscape is shaped by the epigenetic state of the N-terminal nucleosome in relation to CTCF motif orientation [PDF]
CTCF binding sites serve as anchors for the 3D chromatin architecture in vertebrates. The functionality of these anchors is influenced by the residence time of CTCF on chromatin, which is determined by its binding affinity and its interactions with ...
et al +4 more
core +1 more source
The FEBS Journal, Volume 293, Issue 17, Page 5340-5362, September 2026.TGF‐β signaling regulates extracellular vesicle (EV) release in cancer cells by modulating the expression and activity of genes associated with EV biogenesis. The TGF‐β‐induced upregulation of RAB4A expression facilitates fast endosomal recycling, a process that limits the fusion of multivesicular bodies with the plasma membrane and EV secretion. Hence,
Dorival Mendes Rodrigues‐Junior +5 more
wiley +1 more source
Nonlinearities and Switch‐Like Behavior in Gene Expression: From Genetics to Biochemistry and Back
The FASEB Journal, Volume 40, Issue 16, 31 August 2026.Modest changes in transcription‐factor or chromatin‐regulator dosage can have disproportionate effects when gene‐regulatory systems operate near nonlinear thresholds. Sigmoidal input–output relationships, chromatin and cofactor recruitment, and changes in threshold position or response steepness provide molecular routes by which quantitative dosage ...
Reiner A. Veitia, James A. Birchler
wiley +1 more source
CTCF aligns single-cell TAD-like domain boundaries and stabilizes long-range active chromatin clusters. [PDF]
Sci AdvChen Z +8 more
europepmc +1 more source
Epigenetic regulation and chromatin organization in cystic fibrosis airways. [PDF]
J Cyst FibrosDe Ganzó A +4 more
europepmc +1 more source
CTCF delimits a DNA methylation transition at the intergenic region between the embryonic and adult α-globin genes. [PDF]
EpigeneticsTapia-Urzúa G +8 more
europepmc +1 more source
ADP-ribose polymers localized on Ctcf-Parp1-Dnmt1 complex prevent methylation of Ctcf target sites
, 2010 Poly(ADP-ribosyl)ation (PARylation) is involved in the maintaining of genomic methylation pattern through its control of DNA methyltranferase 1 (Dnmt1) activity.
REALE, Anna +8 more
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