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Role of CTCF in DNA damage response [PDF]
Mutation Research - Reviews in Mutation Research, 2019 CCCTC-binding factor (CTCF) is a highly conserved, ubiquitously expressed zinc finger protein. CTCF is a multifunctional protein, associated with a number of vital cellular processes such as transcriptional activation, repression, insulation, imprinting and genome organization.
Suresh Cuddapah +2 more
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The tumor suppressor role of CTCF
Journal of Cellular Physiology, 2011AbstractCTCF is an evolutionary conserved and ubiquitously expressed protein that binds thousands of sites in the human genome. Ectopic expression of CTCF in various normal and tumoral human cell lines inhibits cell division and clonogenicity, with the consequence to consider CTCF a potential tumor‐suppressor factor.
Fiorentino, Francesco Paolo +1 more
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Embryogenesis without CTCF in flies and vertebrates
Nature Structural & Molecular Biology, 2021CTCF is a conserved DNA- and RNA-binding protein with roles in genome folding and transcriptional regulation. Two recent studies investigated how CTCF knockout perturbs genome biology and derails embryogenesis in zebrafish and Drosophila melanogaster, revealing contrasting effects across species.
Geoffrey Fudenberg, Elphège P. Nora
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Regulation of 3D chromatin organization by CTCF
Current Opinion in Genetics & Development, 2021Studies of nuclear architecture using chromosome conformation capture methods have provided a detailed view of how chromatin folds in the 3D nuclear space. New variants of this technology now afford unprecedented resolution and allow the identification of ever smaller folding domains that offer new insights into the mechanisms by which this ...
Jian-Feng Xiang, Victor G Corces
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Expression of chicken CTCF gene in COS-1 cells and partial purification of CTCF protein
Biochemistry (Moscow), 2013The chicken gene for transcription factor CTCF was expressed in COS-1 mammalian cells. The CTCF protein containing polyhistidine tag was partially purified using metallo-affinity and ion-exchange chromatography. The expressed protein localized in the cell nucleus and was shown to be functionally active in the electrophoretic mobility shift assay and ...
E S, Kotova +4 more
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The many roles of the transcriptional regulator CTCF
Biochemistry and Cell Biology, 2003The nuclear factor CTCF was first identified as one of the factors binding to the regulatory regions of the c-myc gene. Further study of this protein revealed roles in transcriptional repression, insulator function, and imprinting genetic information. Recent studies have provided new insight into the mechanism through which this factor acts at various
Katherine L, Dunn, James R, Davie
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CTCF–CTCF loops and intra-TAD interactions show differential dependence on cohesin ring integrity
Nature Cell Biology, 2022The ring-like cohesin complex mediates sister-chromatid cohesion by encircling pairs of sister chromatids. Cohesin also extrudes loops along chromatids. Whether the two activities involve similar mechanisms of DNA engagement is not known. We implemented an experimental approach based on isolated nuclei carrying engineered cleavable RAD21 proteins to ...
Yu Liu, Job Dekker
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A tour of 3D genome with a focus on CTCF
Seminars in Cell & Developmental Biology, 2019The complex three-dimensional (3D) structure of the genome plays critical roles in the maintenance of genome stability, organization, and dynamics and in regulation of gene expression for understanding molecular mechanisms and diseases. Chromatin maintains biological functions and transcriptional activities through long distance interaction and ...
Diane C, Wang +3 more
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CTCF and BORIS in genome regulation and cancer
Current Opinion in Genetics & Development, 2014CTCF plays a vital role in chromatin structure and function. CTCF is ubiquitously expressed and plays diverse roles in gene regulation, imprinting, insulation, intra/interchromosomal interactions, nuclear compartmentalisation, and alternative splicing. CTCF has a single paralogue, the testes-specific CTCF-like gene (CTCFL)/BORIS.
Amy D, Marshall +2 more
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Roles of CTCF in conformation and functions of chromosome
Seminars in Cell & Developmental Biology, 2019CCCTC-binding factor (CTCF) plays indispensable roles in transcriptional inhibition/activation, insulation, gene imprinting, and regulation of 3Dchromatin structure. CTCF contributes to formation of genome multi-dimensions, regulation of dimensional changes, or control of central signals to transcriptional networks.
Fangming, Liu +2 more
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