Results 181 to 190 of about 31,777 (224)

Alterations in chromatin organization promote totipotent-like features in a DPPA2/DUX-dependent manner. [PDF]

EMBO J
Carey GI, Vega-Sendino M, Tillo D, Hoelscher SC, Khan A, Taukulis I, Olbrich T, Saykali B, Tran AD, Soni B, Lee Fong A, Mikolaj M, Harned A, Narayan K, Kruhlak MJ, Kelly M, Liu NQ, de Wit E, Ruiz S.   +18 more
europepmc   +1 more source

hicream: A flexible framework to identify significantly different regions in Hi-C data. [PDF]

Bioinformatics
Jorge E, Hocking TD, Neuvial P, Vialaneix N, Foissac S.   +4 more
europepmc   +1 more source

The Structural Basis for Cohesin–CTCF-Anchored Loops

Nature, 2020
Cohesin catalyses the folding of the genome into loops that are anchored by CTCF1. The molecular mechanism of how cohesin and CTCF structure the 3D genome has remained unclear. Here we show that a segment within the CTCF N terminus interacts with the SA2–
Yan LI, Daniel Panne, Kyle W Muir
exaly   +8 more sources

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CTCF Works Better Under Tension

Nature Reviews Molecular Cell Biology, 2023
Lisa Heinke
exaly   +3 more sources

RNA Interactions Are Essential for CTCF-Mediated Genome Organization [PDF]

Molecular Cell, 2019
The function of the CCCTC-binding factor (CTCF) in the organization of the genome has become an important area of investigation, but the mechanisms by which CTCF dynamically contributes to genome organization are not clear.
Ricardo Saldaña-Meyer, Benoit G. Bruneau, Jane Skok   +2 more
exaly   +2 more sources

Embryogenesis without CTCF in flies and vertebrates

Nature Structural & Molecular Biology, 2021
CTCF is a conserved DNA- and RNA-binding protein with roles in genome folding and transcriptional regulation. Two recent studies investigated how CTCF knockout perturbs genome biology and derails embryogenesis in zebrafish and Drosophila melanogaster, revealing contrasting effects across species.
Geoffrey Fudenberg, Elphège P. Nora
openaire   +2 more sources

The tumor suppressor role of CTCF

Journal of Cellular Physiology, 2011
AbstractCTCF is an evolutionary conserved and ubiquitously expressed protein that binds thousands of sites in the human genome. Ectopic expression of CTCF in various normal and tumoral human cell lines inhibits cell division and clonogenicity, with the consequence to consider CTCF a potential tumor‐suppressor factor.
Fiorentino, Francesco Paolo, Giordano, Antonio   +1 more
openaire   +4 more sources