Results 171 to 180 of about 23,786 (199)

Dissecting the functional roles of CTCF and CTCF-s in human embryonic stem cells

Journal of Genetics and Genomics
CTCF is a highly conserved zinc finger protein that plays critical roles in transcriptional regulation and three-dimensional (3D) genome organization. An alternative splice isoform of CTCF (CTCF-s), lacking the N-terminal domain and 2.5 zinc fingers, competes with CTCF for genomic occupancy and reduces CTCF-mediated chromatin interactions. However, the
Hongxin Zhong, Yuli Lu, Jie Zhang, Gongcheng Hu, Guangjin Pan, Hongjie Yao   +5 more
openaire   +2 more sources

Setting new boundaries with transcription and CTCF

Nature Genetics, 2020
How do boundary elements divide chromosomes into domains? A new study uses random genomic insertions to show how small genomic fragments can shape chromatin folding through the interplay of loop extrusion and compartmentalization. Spoiler: context matters.
Erika C. Anderson, Elphège P. Nora
openaire   +2 more sources

Jpx RNA regulates CTCF anchor site selection and formation of chromosome loops

Cell, 2021
Jeannie Lee, Hsueh-Ping Catherine Chu, Hun-Goo Lee   +2 more
exaly  

G-quadruplexes associated with R-loops promote CTCF binding

Molecular Cell, 2023

exaly  

Genetics and Epigenetics of the Multifunctional Protein CTCF

2007
Recent advances in studying long-range chromatin interactions have shifted focus from the transcriptional regulation by nearby regulatory elements to recognition of the role of higher-order chromatin organization within the nucleus. These advances have also suggested that CCCTC-binding factor (CTCF), a known chromatin insulator protein, may play a ...
openaire   +2 more sources

CTCF and R-loops are boundaries of cohesin-mediated DNA looping

Molecular Cell, 2023
Edward Banigan, Yoori Kim, Xiao-Chen Bai   +2 more
exaly  

CTCF shapes chromatin structure and gene expression in health and disease

EMBO Reports, 2022
Aleksandra Pekowska, Marcin Janowski, Bondita Dehingia   +2 more
exaly  

CTCF

2011
openaire   +2 more sources

CTCF mediates chromatin looping via N-terminal domain-dependent cohesin retention

Proceedings of the National Academy of Sciences of the United States of America, 2020
VÍCTOR Lobanenkov, Pugacheva Em, Gabriel Zentner   +2 more
exaly  

On the choreography of genome folding: A grand pas de deux of cohesin and CTCF

Current Opinion in Cell Biology, 2021
Benjamin Rowland
exaly