Results 121 to 130 of about 31,777 (224)

The shared genetic architecture of the TDP‐43 spectrum: Bridging clinical FTLD and neuropathological endophenotypes

Alzheimer's &Dementia, Volume 22, Issue 11, November 2026.
Abstract INTRODUCTION TAR DNA‐binding protein 43 (TDP‐43) proteinopathies encompass a spectrum of conditions including frontotemporal lobar degeneration with TDP‐43 inclusions (FTLD‐TDP), limbic‐predominant age‐related TDP‐43 encephalopathy (LATE‐NC), and hippocampal sclerosis (HS).
Maulikkumar Patel, Pawan Kumar, Daniel Western, Matthew Johnson, Menghan Liu, John Budde, Carlos Cruchaga, Cyril Pottier   +7 more
wiley   +1 more source

ADP-ribose polymers localized on Ctcf-Parp1-Dnmt1 complex prevent methylation of Ctcf target sites

, 2010
Poly(ADP-ribosyl)ation (PARylation) is involved in the maintaining of genomic methylation pattern through its control of DNA methyltranferase 1 (Dnmt1) activity.
REALE, Anna, Perilli M., CALABRESE, ROBERTA, Passananti C., ZAMPIERI, Michele, GUASTAFIERRO, Tiziana, CICCARONE, FABIO, BACALINI, MARIA GIULIA, CAIAFA, Paola   +8 more
core  

CTCF-cluster mapping and statistic estimation in K562 cells.

, 2012
The random probability of CTCF overlapping was calculated based on the more than 10,000 simulated numbers versus the observed numbers in each category of CTCF-clusters.
Shengqi Wang (13970), Hebing Chen (150828), Yao Tian (150830), Wenjie Shu (15901), Xiaochen Bo (13966)   +4 more
core   +1 more source

Mechanistic Study of GSDME and CXCL10 in SUV39H1‐Mediated Pyroptosis and Immune Suppression in Cervical Cancer

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Cervical cancer (CC) remains a major global health challenge characterized by high incidence and mortality. The histone methyltransferase suppressor of variegation 3–9 homolog 1 (SUV39H1) has emerged as a key epigenetic regulator in tumor progression, but its role in modulating pyroptosis and remodeling of the immune microenvironment in CC ...
Li Zhang, Peiting Sheng, Dongge Cai, Ziyue Zhao, Xiaoling Wu, Yan'e Gao   +5 more
wiley   +1 more source

Protein Lactylation in Cancer: From Mechanisms to Therapy

MedComm, Volume 7, Issue 11, November 2026.
Increased glycolysis and lactate accumulation promote histone and nonhistone protein lactylation, linking tumor metabolic reprogramming to treatment adaptation. Lactylation enhances DNA repair, suppresses antitumor immunity, strengthens antioxidant defenses, and facilitates cell‐cycle checkpoint escape, collectively promoting resistance to chemotherapy,
Wentian Huang, Ping Hu, Shun Wang, Xide Zhang, Ziran Ye, Shengqiang Chen, Fu Gao, Yuanyuan Chen, Yanyong Yang   +8 more
wiley   +1 more source

CTCF driven TERRA transcription facilitates completion of telomere DNA replication

, 2017
Telomere repeat DNA forms a nucleo-protein structure that can obstruct chromosomal DNA replication, especially under conditions of replication stress. Transcription of telomere repeats can initiate at subtelomeric CTCF-binding sites to generate telomere ...
Olga Vladimirova, Stephen Tutton, Zhuo Wang, Zhong Deng, Paul M. Lieberman, Kate Beishline   +5 more
core   +1 more source

Genome Aging in Women: Hematopoietic Loss of X Chromosome as An Exemplar

Aging Cell, Volume 25, Issue 11, November 2026.
As studies at the intersection of genetics and aging are rapidly advancing, genome aging provides a novel mechanism by which aging phenotypes occur. In this Review, the authors examine the rise, expansion, and the consequences of X chromosome loss in female blood cells.
Xihan Guo, Xueqin Dai
wiley   +1 more source

CTCF contributes in a critical way to spermatogenesis and male fertility

, 2016
The CCCTC-binding factor (CTCF) is an architectural protein that governs chromatin organization and gene expression in somatic cells. Here, we show that CTCF regulates chromatin compaction necessary for packaging of the paternal genome into mature sperm.
Lilienthal, I, Hoog, C, Galjart, Niels; id_orcid, Hernandez-Hernandez, A, Fukuda, N, Galjart, N   +5 more
core   +1 more source

CTCF is selectively required for maintaining chromatin accessibility and gene expression in human erythropoiesis

Genome Biology
Background CTCF is considered as the most essential transcription factor regulating chromatin architecture and gene expression. However, genome-wide impact of CTCF on erythropoiesis has not been extensively investigated.
Xue Yang, Li Cheng, Ye Xin, Jianxiang Zhang, Xinfeng Chen, Jinchao Xu, Mengli Zhang, Ruopeng Feng, Judith Hyle, Wenjie Qi, Wojciech Rosikiewicz, Beisi Xu, Chunliang Li, Peng Xu   +13 more
doaj   +1 more source

Machine learning enables pan-cancer identification of mutational hotspots at persistent CTCF binding sites

CCCTC-binding factor (CTCF) is an insulator protein that binds to a highly conserved DNA motif and facilitates regulation of three-dimensional (3D) nuclear architecture and transcription.
Achinger-Kawecka, J., Campbell, E., Clark, S.J., Khoury, A., Chen, W., Stewart, A.G., Zeng, Y.C., Jones, A.K.   +7 more
core   +1 more source