Results 61 to 70 of about 23,786 (199)
Activation of oxidative stress-regulated Bcl-3 suppresses CTCF in corneal epithelial cells. [PDF]
PLoS ONE, 2011 Epigenetic factor CTCF (CCCTC binding factor) plays important roles in genetic controls of the cell fate. Previous studies found in corneal epithelial cells that CTCF is regulated by epidermal growth factor (EGF) through activation of NF-κB p65/p50.
Yumei Wang, Luo Lu
doaj +1 more source
Advanced Intelligent Systems, EarlyView.FluoAI is a two‐stage, label‐free method for quantifying nanomaterial‐induced cytotoxicity from conventional fluorescence microscopy images. Mask R‐CNN segmentation and DenseNet‐121 classification provide rapid live/dead classification matching human accuracy.
Ugur C. Topkiran +6 more
wiley +1 more source
Epigenetic control of SPI1 gene by CTCF and ISWI ATPase SMARCA5.
PLoS ONE, 2014 CCCTC-binding factor (CTCF) can both activate as well as inhibit transcription by forming chromatin loops between regulatory regions and promoters. In this regard, Ctcf binding on non-methylated DNA and its interaction with the Cohesin complex results in
Martina Dluhosova +5 more
doaj +1 more source
An Artificial CTCF Peptide Triggers Efficient Therapeutic Efficacy in Ocular Melanoma
Molecular Therapy: Oncolytics, 2020 Although CCCTC binding factor (CTCF) has been demonstrated to play a variety of often contradictory roles in tumorigenesis, little is known about its function in the tumorigenesis of ocular melanoma. Here, we generated two artificial CTCF peptides (Decoy-
Xuyang Wen +9 more
doaj +1 more source
IgG Glycosylation‐Dependent CLEC7A Signaling Drives Podocyte Dysfunction in Lupus Nephritis
Arthritis &Rheumatology, EarlyView.Objective Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) that can lead to end‐stage kidney disease and increased mortality. IgG from patients with LN displays abnormal glycosylation, contributing to podocyte injury.
Rohit Upadhyay +3 more
wiley +1 more source
Role of CTCF in the regulation of microRNA expression [PDF]
Frontiers in Genetics, 2012 MicroRNAs (miRNAs) are small non-coding RNAs that regulate expression of various target genes. miRNAs are expressed in a tissue-specific manner and play important roles in cell proliferation, apoptosis, and differentiation. Epigenetic alterations such as DNA methylation and histone modification are essential for chromatin remodeling and regulation of ...
Saito, Yoshimasa, Saito, Hidetsugu
openaire +3 more sources
Genome Biology, 2020 Background CTCF is a key insulator-binding protein, and mammalian genomes contain numerous CTCF sites, many of which are organized in tandem. Results Using CRISPR DNA-fragment editing, in conjunction with chromosome conformation capture, we find that ...
Zhilian Jia +5 more
doaj +1 more source
Dynamic regulation of CTCF stability and sub-nuclear localization in response to stress.
PLoS Genetics, 2021 The nuclear protein CCCTC-binding factor (CTCF) has diverse roles in chromatin architecture and gene regulation. Functionally, CTCF associates with thousands of genomic sites and interacts with proteins, such as cohesin, or non-coding RNAs to facilitate ...
Bettina J Lehman +7 more
doaj +1 more source
Epilepsia Open, EarlyView.Abstract Objectives Adults with developmental and epileptic encephalopathies (DEEs) often enter adult neurology care without etiologic clarification because of incomplete transition from pediatric services, outdated investigations, and attenuation of childhood electro‐clinical features over time.
Giuseppe d’Orsi +10 more
wiley +1 more source
iMetaMed, EarlyView.Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine associated with an imbalance in intestinal homeostasis. m6A‐modifying enzymes, consisting of m6A writers, erasers and readers, plays a pivotal role in the pathogenesis and progression of IBD by affecting four intestinal barriers, including the intestinal mechanical ...
Jiaxian Guo +4 more
wiley +1 more source