Results 61 to 70 of about 23,645 (194)

Activation of oxidative stress-regulated Bcl-3 suppresses CTCF in corneal epithelial cells. [PDF]

PLoS ONE, 2011
Epigenetic factor CTCF (CCCTC binding factor) plays important roles in genetic controls of the cell fate. Previous studies found in corneal epithelial cells that CTCF is regulated by epidermal growth factor (EGF) through activation of NF-κB p65/p50.
Yumei Wang, Luo Lu
doaj   +1 more source

Role of CTCF in the regulation of microRNA expression [PDF]

Frontiers in Genetics, 2012
MicroRNAs (miRNAs) are small non-coding RNAs that regulate expression of various target genes. miRNAs are expressed in a tissue-specific manner and play important roles in cell proliferation, apoptosis, and differentiation. Epigenetic alterations such as DNA methylation and histone modification are essential for chromatin remodeling and regulation of ...
Saito, Yoshimasa, Saito, Hidetsugu
openaire   +3 more sources

Priming with interleukin‐1α and chemical hypoxia modulates the mesenchymal stem cell secretome to dampen microglial inflammation and promote neuroprotection

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose We hypothesised that dual priming of human bone marrow‐derived human mesenchymal stem cells (hBMSCs) with interleukin‐1alpha (IL‐1α) and CoCl2 (a hypoxia mimetic) would modulate their therapeutic efficacy for hypoxic‐ischaemic conditions. Experimental Approach hBMSCs were primed individually or in combination.
Maryam Adenike Salaudeen, Stuart M. Allan, Emmanuel Pinteaux   +2 more
wiley   +1 more source

An Artificial CTCF Peptide Triggers Efficient Therapeutic Efficacy in Ocular Melanoma

Molecular Therapy: Oncolytics, 2020
Although CCCTC binding factor (CTCF) has been demonstrated to play a variety of often contradictory roles in tumorigenesis, little is known about its function in the tumorigenesis of ocular melanoma. Here, we generated two artificial CTCF peptides (Decoy-
Xuyang Wen, Huixue Wang, Peiwei Chai, Jiayan Fan, Xiaoyu Zhang, Tianyi Ding, Renbing Jia, Shengfang Ge, He Zhang, Xianqun Fan   +9 more
doaj   +1 more source

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source

Tandem CTCF sites function as insulators to balance spatial chromatin contacts and topological enhancer-promoter selection

Genome Biology, 2020
Background CTCF is a key insulator-binding protein, and mammalian genomes contain numerous CTCF sites, many of which are organized in tandem. Results Using CRISPR DNA-fragment editing, in conjunction with chromosome conformation capture, we find that ...
Zhilian Jia, Jingwei Li, Xiao Ge, Yonghu Wu, Ya Guo, Qiang Wu   +5 more
doaj   +1 more source

Dynamic regulation of CTCF stability and sub-nuclear localization in response to stress.

PLoS Genetics, 2021
The nuclear protein CCCTC-binding factor (CTCF) has diverse roles in chromatin architecture and gene regulation. Functionally, CTCF associates with thousands of genomic sites and interacts with proteins, such as cohesin, or non-coding RNAs to facilitate ...
Bettina J Lehman, Fernando J Lopez-Diaz, Thom P Santisakultarm, Linjing Fang, Maxim N Shokhirev, Kenneth E Diffenderfer, Uri Manor, Beverly M Emerson   +7 more
doaj   +1 more source

An alternative CTCF isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis [PDF]

Nature Communications, 2019
AbstractCTCF plays key roles in gene regulation, chromatin insulation, imprinting, X chromosome inactivation and organizing the higher-order chromatin architecture of mammalian genomes. Previous studies have mainly focused on the roles of the canonical CTCF isoform.
Jiao Li, Kaimeng Huang, Gongcheng Hu, Isaac A. Babarinde, Yaoyi Li, Xiaotao Dong, Yu-Sheng Chen, Liping Shang, Wenjing Guo, Junwei Wang, Zhaoming Chen, Andrew P. Hutchins, Yun-Gui Yang, Hongjie Yao   +13 more
openaire   +3 more sources

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

The FEBS Journal, EarlyView.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio, Ana Lucia Cuadros Gamboa, Martina Bertocchi, Filippo Chiesa, Francesca Cargnin, Ettore Mosca, Paride Pelucchi, Viviana Tritto, Stefania Corti, Isabella Ceccherini, Paola Riva, Roberta Benfante, Diego Fornasari   +12 more
wiley   +1 more source

Epigenetic control of SPI1 gene by CTCF and ISWI ATPase SMARCA5.

PLoS ONE, 2014
CCCTC-binding factor (CTCF) can both activate as well as inhibit transcription by forming chromatin loops between regulatory regions and promoters. In this regard, Ctcf binding on non-methylated DNA and its interaction with the Cohesin complex results in
Martina Dluhosova, Nikola Curik, Jarmila Vargova, Anna Jonasova, Tomas Zikmund, Tomas Stopka   +5 more
doaj   +1 more source