Results 61 to 70 of about 29,893 (236)

CTCF-binding sites are often mutated when acting as modulators of chromatin structure.

, 2016
CTCF-motifs are highly enriched inside loop anchor points and across domain boundaries (A, C). The number of substitutions in CTCF-motifs is increased for motifs that are located in loop anchor points (B); for domain boundaries, no significant increase ...
Martin S. Taylor (257588), Colin A. Semple (232977), Vera B. Kaiser (483580)   +2 more
core   +1 more source

CTCF Binding Polarity Determines Chromatin Looping [PDF]

, 2015
CCCTC-binding factor (CTCF) is an architectural protein involved in the three-dimensional (3D) organization of chromatin. In this study, we assayed the 3D genomic contact profiles of a large number of CTCF binding sites with high-resolution 4C-seq.
Splinter, Erik, Krijger, Peter H L, Vos, Erica S M, de Wit, Elzo, Teunissen, Hans, Wijchers, Patrick J, de Laat, Wouter, Valdes-Quezada, Christian, Holwerda, Sjoerd J B, Verstegen, Marjon J A M   +9 more
core   +1 more source

Genomic imprinting defects in the growth disorder Beckwith-Wiedemann syndrome [PDF]

, 2009
The imprinting control region (IC1) of the human IGF2 and H19 genes is represented by a chromatin insulator located between the two genes that prevents the activation of IGF2 and allows the activation of H19 on the maternal chromosome. Deletions removing
Citro, Valentina
core   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

CTCF-mediated chromatin interactions of PAX6 with RCN1 and ADAM17 genes.

, 2016
(A) Illustration of circularized chromosome conformation capture (4C) primers designs relative to HindIII restriction sites which are adjacent to CTCF binding sites 2 and 3 on PAX6 promoter.
Luo Lu (345233), Jie Wang (16762), Wei Dai (95957), Ling Wang (56577), Shanli Tsui (326848)   +4 more
core   +1 more source

CTCF Haploinsufficiency Destabilizes DNA Methylation and Predisposes to Cancer

Cell Reports, 2014
Epigenetic alterations, particularly in DNA methylation, are ubiquitous in cancer, yet the molecular origins and the consequences of these alterations are poorly understood.
Christopher J. Kemp, James M. Moore, Russell Moser, Brady Bernard, Matt Teater, Leslie E. Smith, Natalia A. Rabaia, Kay E. Gurley, Justin Guinney, Stephanie E. Busch, Rita Shaknovich, Victor V. Lobanenkov, Denny Liggitt, Ilya Shmulevich, Ari Melnick, Galina N. Filippova   +15 more
doaj   +1 more source

Dynamic regulation of CTCF stability and sub-nuclear localization in response to stress.

PLoS Genetics, 2021
The nuclear protein CCCTC-binding factor (CTCF) has diverse roles in chromatin architecture and gene regulation. Functionally, CTCF associates with thousands of genomic sites and interacts with proteins, such as cohesin, or non-coding RNAs to facilitate ...
Bettina J Lehman, Fernando J Lopez-Diaz, Thom P Santisakultarm, Linjing Fang, Maxim N Shokhirev, Kenneth E Diffenderfer, Uri Manor, Beverly M Emerson   +7 more
doaj   +1 more source

CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano, Allen C. Luo, Paul Taufalele, Jenna A. Dombroski, Ehsan Aalaei, Schyler J. Rowland, Melissa S. Cantú, Alexandria T. Carter, Samantha V. Knoblauch, Cynthia A. Reinhart‐King, Michael R. King   +10 more
wiley   +1 more source

Tandem CTCF sites function as insulators to balance spatial chromatin contacts and topological enhancer-promoter selection

Genome Biology, 2020
Background CTCF is a key insulator-binding protein, and mammalian genomes contain numerous CTCF sites, many of which are organized in tandem. Results Using CRISPR DNA-fragment editing, in conjunction with chromosome conformation capture, we find that ...
Zhilian Jia, Jingwei Li, Xiao Ge, Yonghu Wu, Ya Guo, Qiang Wu   +5 more
doaj   +1 more source

Auxin-inducible degron 2 system deciphers functions of CTCF domains in transcriptional regulation

Genome Biology, 2023
Background CTCF is a well-established chromatin architectural protein that also plays various roles in transcriptional regulation. While CTCF biology has been extensively studied, how the domains of CTCF function to regulate transcription remains unknown.
Judith Hyle, Mohamed Nadhir Djekidel, Justin Williams, Shaela Wright, Ying Shao, Beisi Xu, Chunliang Li   +6 more
doaj   +1 more source