Results 61 to 70 of about 31,777 (224)
CHD8‐Dependent Chromatin Licensing Sustains Trophoblast Stem Cell Transcriptional Programs
Advanced Science, EarlyView.In this study, Huang et al., identify chromatin remodeler CHD8 as an essential factor in TSC maintenance and placental development. CHD8‐dependent chromatin accessibility supports the occupancy of key trophoblast TFs and is coupled to KMT2A‐associated H3K4me3 deposition at TSC stem and cell cycle genes, providing a permissive chromatin environment for ...
Yuanyuan Huang +16 more
wiley +1 more source
CTCF-binding sites and localization of XL9 inside the MHC-II locus.
, 2018 Schematic diagram showing the relative positions of MHC-II genes (grey shaded boxes) and CTCF binding sites (black ovals) on human chromosome 6p21.3 as identified by Majumder and Boss [20] with the XL9 region flanked by HLA-DRB1 and HLA-DQA1 (upper 2 ...
Christoph Arens (5746865) +6 more
core +1 more source
, 2007 CTCF is a transcription factor with highly versatile functions ranging from gene activation and repression to the regulation of insulator function and imprinting.
Kang, SY +9 more
core +2 more sources
The role of CTCF in regulating nuclear organization [PDF]
The Journal of Experimental Medicine, 2008 The spatial organization of the genome is thought to play an important part in the coordination of gene regulation. New techniques have been used to identify specific long-range interactions between distal DNA sequences, revealing an ever-increasing complexity to nuclear organization.
Williams, Adam, Flavell, Richard A.
openaire +2 more sources
CTCF regulates lipid metabolism and gene expression in mouse AML12 liver cell line
Shanghai Jiaotong Daxue xuebao. Yixue banObjective·To clarify the regulatory role of CCCTC-binding factor (CTCF) in lipid metabolism in liver cells, and explore the mechanisms by which CTCF regulates liver cell gene expression.Methods·Immortalized AML12 liver cell line was used as a model to ...
CHEN Huaihuang, ZUO Wu, BIAN Qian
doaj +1 more source
BMC Genomics, 2019 Background CCCTC-Binding Factor (CTCF), also known as 11-zinc finger protein, participates in many cellular processes, including insulator activity, transcriptional regulation and organization of chromatin architecture.
Wei Wang, Gang Ren, Ni Hong, Wenfei Jin
doaj +1 more source
Advanced Science, EarlyView.This study identifies the glucose/glutamine sensitive lncRNA GSLR as a driver of lung adenocarcinoma progression. Nutrient restriction reduces chromatin accessibility at the GSLR locus and blocks CTCF‐mediated transcriptional regulation. GSLR directly interacts with DHX9 and recruits it to the CKB promoter, arresting R‐loop accumulation and promoting ...
Xinyi Qian +9 more
wiley +1 more source
Advanced Science, EarlyView.This study established a one‐step method inducing pro‐spermatogonia‐like (activating SOX17) and oogonia‐like (activating SOX17/TFAP2C) cells from porcine pgEpiSCs with a NANOS3‐tdTomato reporter. EGF activates the core PGC program and supports survival; BMP4 further induces NANOS3 and DDX4 expression; IWR1 enhances PGCLC efficiency by suppressing ...
Pengcheng He +14 more
wiley +1 more source
, 2013 (A) EMSA showing a mobility shift for the FXN 5’ UTR probe and CTCF-positive DM1 (1) probe [35], while there is no such shift detected for the FXN upstream GAA (Up) probe, FXN downstream GAA (Down) probe or CTCF-negative DM1 (3) probe [35].
Chiranjeevi Sandi (283956) +3 more
core +1 more source
Dynamic regulation of CTCF stability and sub-nuclear localization in response to stress.
PLoS Genetics, 2021 The nuclear protein CCCTC-binding factor (CTCF) has diverse roles in chromatin architecture and gene regulation. Functionally, CTCF associates with thousands of genomic sites and interacts with proteins, such as cohesin, or non-coding RNAs to facilitate ...
Bettina J Lehman +7 more
doaj +1 more source