Results 51 to 60 of about 6,498 (147)

Functional role of CCCTC binding factor in insulin‐stimulated cell proliferation [PDF]

Cell Proliferation, 2007
Abstract.  Objectives: CCCTC binding factor (CTCF) is a nuclear protein containing an 11‐zinc‐finger DNA‐binding domain. CTCF plays important roles in the regulation of epigenetics and gene transcription. As a multifunctional protein, CTCF is also involved in the regulation of cell proliferation and of apoptosis.
J, Gao, T, Li, L, Lu
openaire   +2 more sources

CRISPR/Cas9 offers a new tool for studying the role of chromatin architecture in disease pathogenesis

Genome Biology, 2018
A recent study used CRISPR/Cas9 to reveal long-range looping between disease-related genes and their regulatory elements that is mediated by the CCCTC-binding factor (CTCF) in prostate cancer.
Xiang Guo, Ann Dean
doaj   +1 more source

CTCF loss induces giant lamellar bodies in Purkinje cell dendrites

Acta Neuropathologica Communications, 2022
CCCTC-binding factor (CTCF) has a key role in higher-order chromatin architecture that is important for establishing and maintaining cell identity by controlling gene expression.
Teruyoshi Hirayama, Yuuki Kadooka, Etsuko Tarusawa, Sei Saitoh, Hisako Nakayama, Natsumi Hoshino, Soichiro Nakama, Takahiro Fukuishi, Yudai Kawanishi, Hiroki Umeshima, Koichi Tomita, Yumiko Yoshimura, Niels Galjart, Kouichi Hashimoto, Nobuhiko Ohno, Takeshi Yagi   +15 more
doaj   +1 more source

CCCTC-binding Factor Activates PARP-1 Affecting DNA Methylation Machinery [PDF]

Journal of Biological Chemistry, 2008
Our previous data have shown that in L929 mouse fibroblasts the control of methylation pattern depends in part on poly(ADP-ribosyl)ation and that ADP-ribose polymers (PARs), both present on poly(ADP-ribosyl)ated PARP-1 and/or protein-free, have an inhibitory effect on Dnmt1 activity.
GUASTAFIERRO, Tiziana, CECCHINELLI, Barbara, ZAMPIERI, Michele, REALE, Anna, RIGGIO, Giuseppe, STHANDIER, Olga Elena, G. Zupi, CALABRESE, Lilia, CAIAFA, Paola   +8 more
openaire   +3 more sources

Demarcation of Topologically Associating Domains Is Uncoupled from Enriched CTCF Binding in Developing Zebrafish

iScience, 2020
Summary: CCCTC-binding factor (CTCF) is a conserved architectural protein that plays crucial roles in gene regulation and three-dimensional (3D) chromatin organization.
Yuvia A. Pérez-Rico, Emmanuel Barillot, Alena Shkumatava   +2 more
doaj   +1 more source

Pericentromeric repetitive ncRNA regulates chromatin interaction and inflammatory gene expression

Nucleus, 2022
Cellular senescence provokes a dramatic alteration of chromatin organization and gene expression profile of proinflammatory factors, thereby contributing to various age-related pathologies via the senescence-associated secretory phenotype (SASP ...
Kenichi Miyata, Akiko Takahashi
doaj   +1 more source

Conditional knock out of transcription factor CTCF in excitatory neurons induces cognitive deficiency

Molecular Brain, 2021
CCCTC-binding factor (CTCF) is a transcription factor that is involved in organizing chromatin structure. A reduction of CTCF expression is known to develop distinct clinical features.
Dong Il Choi, Myeongwon Kim, Somi Kim, Nam-Kyung Yu, Chuljung Kwak, Hyunhyo Seo, Kyungmin Lee, Bong-Kiun Kaang   +7 more
doaj   +1 more source

Transcriptional Control of Subcutaneous Adipose Tissue by the Transcription Factor CTCF Modulates Heterogeneity in Fat Distribution in Women

Cells, 2023
Determining the mechanism driving body fat distribution will provide insights into obesity-related health risks. We used functional genomics tools to profile the epigenomic landscape to help infer the differential transcriptional potential of apple- and ...
Edina Erdos, Katalin Sandor, Crystal L. Young-Erdos, Laszlo Halasz, Steven R. Smith, Timothy F. Osborne, Adeline Divoux   +6 more
doaj   +1 more source

A case of autosomal dominant intellectual disability type 21 with CTCF mutations [PDF]

Jichu yixue yu linchuang
Objective To explore the clinical characteristics of autosomal dominant intellectual disability type 21(MRD21)related with CCCTC-binding factor(CTCF) mutations. Methods The clinical data of an outpatient with CTCF mutations, laboratory and genetic test
DING Juan, MA Mingsheng
doaj   +1 more source

Genetic–epigenetic interactions in cis: a major focus in the post-GWAS era

Genome Biology, 2017
Studies on genetic–epigenetic interactions, including the mapping of methylation quantitative trait loci (mQTLs) and haplotype-dependent allele-specific DNA methylation (hap-ASM), have become a major focus in the post-genome-wide-association-study (GWAS)
Catherine Do, Alyssa Shearer, Masako Suzuki, Mary Beth Terry, Joel Gelernter, John M. Greally, Benjamin Tycko   +6 more
doaj   +1 more source