Results 61 to 70 of about 5,303,548 (144)

CCCTC-binding factor activates PARP-1 affecting DNA methylation machinery

, 2008
Our previous data have shown that in L929 mouse fibroblasts the control of methylation pattern depends in part on poly(ADP-ribosyl) ation and that ADP-ribose polymers (PARs), both present on poly(ADP-ribosyl) ated PARP-1 and/or protein-free, have an ...
Tiziana Guastafierro, GUASTAFIERRO, Tiziana, CECCHINELLI, Barbara, Paola Caiafa, RIGGIO, Giuseppe, CAIAFA, Paola, Lilia Calabrese, G. Zupi, Giuseppe Riggio, Gabriella Zupi, REALE, Anna, STHANDIER, Olga Elena, Barbara Cecchinelli, ZAMPIERI, Michele, Olga Sthandier, CALABRESE, Lilia, Michele Zampieri, Anna Reale   +17 more
core   +1 more source

Comprehensive identification and annotation of cell type-specific and ubiquitous CTCF-binding sites in the human genome. [PDF]

PLoS ONE, 2012
Chromatin insulators are DNA elements that regulate the level of gene expression either by preventing gene silencing through the maintenance of heterochromatin boundaries or by preventing gene activation by blocking interactions between enhancers and ...
Hebing Chen, Yao Tian, Wenjie Shu, Xiaochen Bo, Shengqi Wang   +4 more
doaj   +1 more source

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, Volume 13, Issue 38, 9 July 2026.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source

Altered density of glomerular binding sites for atrial natriuretic factor in bile duct-ligated rats with ascites [PDF]

, 1991
The renal response to atrial natriuretic factor is blunted in cirrhosis with ascites. This might be due to alterations of renal receptors for atrial natriuretic factor.
Vollmar, Angelika M., Vakil, Nimish, Kollenda, Margit C., Gerbes, Alexander L., Reichen, Jürg, Scarborough, Robert M.   +5 more
core   +1 more source

Direct identification of insulator components by insertional chromatin immunoprecipitation. [PDF]

PLoS ONE, 2011
Comprehensive understanding of mechanisms of epigenetic regulation requires identification of molecules bound to genomic regions of interest in vivo. However, non-biased methods to identify molecules bound to specific genomic loci in vivo are limited ...
Toshitsugu Fujita, Hodaka Fujii
doaj   +1 more source

PPP2R3C serves as a negative regulator associated with reduced T cell hyperactivation and renal protection in lupus

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Downregulation of PPP2R3C in lupus CD4+ T cells unleashes JNK/c‑Jun and PLCγ1 signalling, driving calcium influx and inflammatory cytokine production. Reconstitution of PPP2R3C expression curbs T cell activation, lowers autoantibody levels and alleviates lupus nephritis, highlighting PPP2R3C as a promising therapeutic candidate. Abstract Background CD4+
Xuan Fang, Yi Qin, Jinhui Tao, Zhou Zhou, Minglong Cai, Hong Zhang, Xiangpei Li, Xiaomei Li, Zhu Chen   +8 more
wiley   +1 more source

Predicting CTCF cell type active binding sites in human genome

Scientific Reports
The CCCTC-binding factor (CTCF) is pivotal in orchestrating diverse biological functions across the human genome, yet the mechanisms driving its cell type-active DNA binding affinity remain underexplored.
Lu Chai, Jie Gao, Zihan Li, Hao Sun, Junjie Liu, Yong Wang, Lirong Zhang   +6 more
doaj   +1 more source

cccDNA Surrogate MC-HBV–Based Screen Identifies Cohesin Complex as a Novel HBV Restriction FactorSummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Covalently closed circular DNA (cccDNA) of hepatitis B virus (HBV), existing as a stable minichromosome in the hepatocyte, is responsible for persistent HBV infection.
Zhuanchang Wu, Liyuan Wang, Xin Wang, Yang Sun, Haoran Li, Zhaoying Zhang, Caiyue Ren, Xiaohui Zhang, Shuangjie Li, Jinghui Lu, Leiqi Xu, Xuetian Yue, Yue Hong, Qiang Li, Haizhen Zhu, Yaoqin Gong, Chengjiang Gao, Huili Hu, Lifen Gao, Xiaohong Liang, Chunhong Ma   +20 more
doaj   +1 more source

Lactate metabolism and lactylation in female reproductive diseases: From metabolic rewiring to biomarkers and translational therapeutics

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
1. Lactate‐derived histone lactylation links glycolytic reprogramming to epigenetic regulation in female reproductive diseases. 2. In endometriosis, lactylation may promote inflammatory remodelling, immune dysregulation and ferroptosis resistance. 3. In PCOS, lactylation connects metabolic disturbance to granulosa‐cell dysfunction and hyperandrogenism.
Jiajun Qiao, Yue Xiao, Yi Cheng, Weihai Xu, Jing Shu, Shishi Li   +5 more
wiley   +1 more source

VEZF1 elements mediate protection from DNA methylation [PDF]

, 2010
There is growing consensus that genome organization and long-range gene regulation involves partitioning of the genome into domains of distinct epigenetic chromatin states.
Gowher Humaira, Hair, Alan, Miklos Gaszner, West Adam G., Gary Felsenfeld, Jacqueline Dickson, Dickson Jacqueline, Strogantsev, Ruslan, Gaszner Miklos, Dickson, Jacqueline, Adam G West, Humaira Gowher, Gaszner, Miklos, West, Adam G, Gowher, Humaira, West, Adam G., Felsenfeld Gary, Ruslan Strogantsev, Strogantsev Ruslan, Hair Alan, Felsenfeld, Gary, Alan Hair   +21 more
core   +2 more sources