Results 61 to 70 of about 6,498 (147)

Enhancement of transgene expression by nuclear transcription factor Y and CCCTC‐binding factor

Biotechnology Progress, 2018
If a transgene is effectively delivered to a cell, its expression may still be limited by epigenetic mechanisms that silence the transgene. Indeed, once the transgene reaches the nucleus, it may be bound by histone proteins and condensed into heterochromatin or associated with repressor proteins that block transcription.
Devon Zimmerman, Krupa Patel, Matthew Hall, Jacob Elmer   +3 more
openaire   +3 more sources

Distinct properties and functions of CTCF revealed by a rapidly inducible degron system

Cell Reports, 2021
Summary: CCCTC-binding factor (CTCF) is a conserved zinc finger transcription factor implicated in a wide range of functions, including genome organization, transcription activation, and elongation.
Jing Luan, Guanjue Xiang, Pablo Aurelio Gómez-García, Jacob M. Tome, Zhe Zhang, Marit W. Vermunt, Haoyue Zhang, Anran Huang, Cheryl A. Keller, Belinda M. Giardine, Yu Zhang, Yemin Lan, John T. Lis, Melike Lakadamyali, Ross C. Hardison, Gerd A. Blobel   +15 more
doaj   +1 more source

Critical Role for the Transcription Regulator CCCTC-Binding Factor in the Control of Th2 Cytokine Expression [PDF]

The Journal of Immunology, 2009
Abstract Differentiation of naive CD4+ cells into Th2 cells is accompanied by chromatin remodeling at the Th2 cytokine locus allowing the expression of the IL-4, IL-5, and IL-13 genes. In this report, we investigated the role in Th2 differentiation of the transcription regulator CCCTC-binding factor (CTCF).
Ribeiro De Almeida, Claudia, Heath, Helen, Krpic, Sanja, Dingjan, Gemma M., Van Hamburg, Jan Piet, Bergen, Ingrid, Van De Nobelen, Suzanne, Sleutels, Frank, Grosveld, Frank, Galjart, Niels, Hendriks, Rudi W.   +10 more
openaire   +4 more sources

MeCP2 regulates Tet1-catalyzed demethylation, CTCF binding, and learning-dependent alternative splicing of the BDNF gene in Turtle

eLife, 2017
MECP2 mutations underlying Rett syndrome cause widespread misregulation of gene expression. Functions for MeCP2 other than transcriptional are not well understood.
Zhaoqing Zheng, Ganesh Ambigapathy, Joyce Keifer   +2 more
doaj   +1 more source

CTCF acetylation at lysine 20 is required for the early cardiac mesoderm differentiation of embryonic stem cells

Cell Regeneration, 2022
The CCCTC-binding factor (CTCF) protein and its modified forms regulate gene expression and genome organization. However, information on CTCF acetylation and its biological function is still lacking. Here, we show that CTCF can be acetylated at lysine 20
Shixin Gong, Gongcheng Hu, Rong Guo, Jie Zhang, Yiqi Yang, Binrui Ji, Gang Li, Hongjie Yao   +7 more
doaj   +1 more source

Dual function of SF3B2 on chromatin and RNA to regulate transcription in head and neck squamous cell carcinoma

Cell & Bioscience, 2022
RNA is spliced concomitantly with transcription and the process is organized by RNA splicing factors, transcriptional regulators, and chromatin regulators. RNA is spliced in close proximity to transcription machinery. Hence, some RNA splicing factors may
Koji Kitamura, Hidefumi Suzuki, Ryota Abe, Hidenori Inohara, Yasufumi Kaneda, Hidehisa Takahashi, Keisuke Nimura   +6 more
doaj   +1 more source

CTCF Mediates Replicative Senescence Through POLD1

Frontiers in Cell and Developmental Biology, 2021
POLD1, the catalytic subunit of DNA polymerase δ, plays a critical role in DNA synthesis and DNA repair processes. Moreover, POLD1 is downregulated in replicative senescence to mediate aging.
Yuli Hou, Qiao Song, Shichao Gao, Xiaomin Zhang, Yaqi Wang, Jing Liu, Jingxuan Fu, Min Cao, Peichang Wang   +8 more
doaj   +1 more source

An Artificial CTCF Peptide Triggers Efficient Therapeutic Efficacy in Ocular Melanoma

Molecular Therapy: Oncolytics, 2020
Although CCCTC binding factor (CTCF) has been demonstrated to play a variety of often contradictory roles in tumorigenesis, little is known about its function in the tumorigenesis of ocular melanoma. Here, we generated two artificial CTCF peptides (Decoy-
Xuyang Wen, Huixue Wang, Peiwei Chai, Jiayan Fan, Xiaoyu Zhang, Tianyi Ding, Renbing Jia, Shengfang Ge, He Zhang, Xianqun Fan   +9 more
doaj   +1 more source

PPP2R3C serves as a negative regulator associated with reduced T cell hyperactivation and renal protection in lupus

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Downregulation of PPP2R3C in lupus CD4+ T cells unleashes JNK/c‑Jun and PLCγ1 signalling, driving calcium influx and inflammatory cytokine production. Reconstitution of PPP2R3C expression curbs T cell activation, lowers autoantibody levels and alleviates lupus nephritis, highlighting PPP2R3C as a promising therapeutic candidate. Abstract Background CD4+
Xuan Fang, Yi Qin, Jinhui Tao, Zhou Zhou, Minglong Cai, Hong Zhang, Xiangpei Li, Xiaomei Li, Zhu Chen   +8 more
wiley   +1 more source

Lactate metabolism and lactylation in female reproductive diseases: From metabolic rewiring to biomarkers and translational therapeutics

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
1. Lactate‐derived histone lactylation links glycolytic reprogramming to epigenetic regulation in female reproductive diseases. 2. In endometriosis, lactylation may promote inflammatory remodelling, immune dysregulation and ferroptosis resistance. 3. In PCOS, lactylation connects metabolic disturbance to granulosa‐cell dysfunction and hyperandrogenism.
Jiajun Qiao, Yue Xiao, Yi Cheng, Weihai Xu, Jing Shu, Shishi Li   +5 more
wiley   +1 more source