Results 81 to 90 of about 5,303,548 (144)

An intuitionistic approach to scoring DNA sequences against transcription factor binding site motifs [PDF]

, 2010
Background: Transcription factors (TFs) control transcription by binding to specific regions of DNA called transcription factor binding sites (TFBSs). The identification of TFBSs is a crucial problem in computational biology and includes the subtask of ...
García Alcalde, Fernando, Blanco Morón, Armando, Armando Blanco, Blanco, A., Blanco Armando, Shepherd Adrian J, Shepherd, Adrian J., Garcia-Alcalde Fernando, Garcia-Alcalde, F., Adrian J Shepherd, Fernando Garcia-Alcalde   +10 more
core   +1 more source

Depletion of CTCF disrupts PSG gene expression in the human trophoblast cell line Swan 71

FEBS Open Bio, 2021
Pregnancy‐specific glycoproteins (PSGs) are fetal proteins secreted by the placenta during pregnancy. The PSG level in maternal serum is an indicator of risk for pregnancy complications.
Da Som Jeong, Myoung Hee Kim, Ji‐Yeon Lee   +2 more
doaj   +1 more source

Metamorphosis and lncRNAs: A Close Relationship

genesis, Volume 64, Issue 2, April 2026.
ABSTRACT The classical definition of metamorphosis is a post‐embryonic transformation, such as from a tadpole to a froglet. However, recent studies suggest this process occurs to some degree in all vertebrates, as the underlying endocrine and molecular pathways are highly conserved. With the advent of high‐throughput sequencing, transcriptomic data for
H. Herrera‐Orozco, H. A. Pérez‐Mendoza   +1 more
wiley   +1 more source

CTCF regulates lipid metabolism and gene expression in mouse AML12 liver cell line

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To clarify the regulatory role of CCCTC-binding factor (CTCF) in lipid metabolism in liver cells, and explore the mechanisms by which CTCF regulates liver cell gene expression.Methods·Immortalized AML12 liver cell line was used as a model to ...
CHEN Huaihuang, ZUO Wu, BIAN Qian
doaj   +1 more source

Transcript‐Specific DNA Methylation Alterations of the RASSF1 Locus in Cancer Cells

Genes, Chromosomes and Cancer, Volume 65, Issue 4, April 2026.
ABSTRACT Background The locus encoding Ras association domain family member 1 (RASSF1) encodes multiple transcripts with opposing roles in cancer, such as RASSF1A (tumor suppressor), RASSF1C (oncogene), and the lncRNA RASSF1‐AS1 (function undefined).
Litzy Gisella Bermudez, Camila Bernal Forigua, Carmen María Ayala‐Roldán, Jesús Manuel Romero, Rafael R. Ariza, Teresa Morales‐Ruiz, Teresa Roldán‐Arjona, Alejandra Cañas, Adriana Rojas   +8 more
wiley   +1 more source

Cooperative Roles of Pds5a and Pds5b Constrain Long‐Range Chromatin Interactions in Vertebrate Embryos

Development, Growth &Differentiation, Volume 68, Issue 3, April 2026.
ABSTRACT Three‐dimensional (3D) genome organization is dynamically restructured during early vertebrate development, yet how chromatin domains are established remains poorly understood. In particular, the contribution of individual cohesin regulators to this process during embryogenesis is unclear.
Shinra Ikeda, Hiroyuki Takeda, Ryohei Nakamura   +2 more
wiley   +1 more source

Hypoxia regulates Th17/Treg balance by altering chromatin accessibility and gene expression

The FEBS Journal, Volume 293, Issue 8, Page 2393-2416, April 2026.
T‐cell differentiation into Th17 or iTreg cells is key to inflammation control. Integrated RNA‐seq and ATAC‐seq analyses reveal that hypoxia induces more extensive gene expression changes in iTreg cells. Elevated levels of Hif1a and Stat3, along with increased accessibility to key transcription factor motifs, may predispose these cells toward ...
Mariana Cázares‐Olivera, Shiyang Song, Sofia Ylinen, Talha Qureshi, Bin Li, Zhi Chen   +5 more
wiley   +1 more source

Classifying human promoters by occupancy patterns identifies recurring sequence elements, combinatorial binding, and spatial interactions

BMC Biology, 2018
Background Characterizing recurring sequence patterns in human promoters has been a challenging undertaking even nowadays where a near-complete overview of promoters exists.
Xinyi Yang, Martin Vingron
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Chromatin Topology Reconfiguration Orchestrates Thermotolerant Male Fertility via GhAL5 in Cotton

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This study investigates cotton’s high‐temperature (HT) response using multi‑omics. Dynamic 3D genome changes drive expression bias affecting male fertility. The tolerant line shows controlled chromatin dynamics, while the sensitive line exhibits overactivation.
Yanlong Li, Jing Yang, Weiran Wang, Chunyang Zuo, Liuling Pei, Yizan Ma, Rui Zhang, Yaru Fan, Huanhuan Ma, Yawei Li, Ruizhen Liu, Shuangxia Jin, Longfu Zhu, Jie Kong, Xianlong Zhang, Ling Min   +15 more
wiley   +1 more source