Results 81 to 90 of about 6,498 (147)

Metamorphosis and lncRNAs: A Close Relationship

genesis, Volume 64, Issue 2, April 2026.
ABSTRACT The classical definition of metamorphosis is a post‐embryonic transformation, such as from a tadpole to a froglet. However, recent studies suggest this process occurs to some degree in all vertebrates, as the underlying endocrine and molecular pathways are highly conserved. With the advent of high‐throughput sequencing, transcriptomic data for
H. Herrera‐Orozco, H. A. Pérez‐Mendoza   +1 more
wiley   +1 more source

Long-distance communication: Looping of human papillomavirus genomes regulates expression of viral oncogenes.

PLoS Biology, 2018
High-risk human papillomaviruses (HPVs) are a major cause of cancers. HPVs infect epithelial cells, and viral oncogenes disrupt several cellular processes, including cell division, differentiation, and apoptosis.
Adityarup Chakravorty, Bill Sugden
doaj   +1 more source

CTCF deletion alters the pluripotency and DNA methylation profile of human iPSCs

Frontiers in Cell and Developmental Biology, 2023
Pluripotent stem cells are characterized by their differentiation potential toward endoderm, mesoderm, and ectoderm. However, it is still largely unclear how these cell-fate decisions are mediated by epigenetic mechanisms.
Deepika Puri, Deepika Puri, Catharina Maaßen, Catharina Maaßen, Monica Varona Baranda, Monica Varona Baranda, Kira Zeevaert, Kira Zeevaert, Lena Hahnfeld, Lena Hahnfeld, Annika Hauser, Annika Hauser, Giulia Fornero, Giulia Fornero, Mohamed H. Elsafi Mabrouk, Mohamed H. Elsafi Mabrouk, Wolfgang Wagner, Wolfgang Wagner   +17 more
doaj   +1 more source

Transcript‐Specific DNA Methylation Alterations of the RASSF1 Locus in Cancer Cells

Genes, Chromosomes and Cancer, Volume 65, Issue 4, April 2026.
ABSTRACT Background The locus encoding Ras association domain family member 1 (RASSF1) encodes multiple transcripts with opposing roles in cancer, such as RASSF1A (tumor suppressor), RASSF1C (oncogene), and the lncRNA RASSF1‐AS1 (function undefined).
Litzy Gisella Bermudez, Camila Bernal Forigua, Carmen María Ayala‐Roldán, Jesús Manuel Romero, Rafael R. Ariza, Teresa Morales‐Ruiz, Teresa Roldán‐Arjona, Alejandra Cañas, Adriana Rojas   +8 more
wiley   +1 more source

Cooperative Roles of Pds5a and Pds5b Constrain Long‐Range Chromatin Interactions in Vertebrate Embryos

Development, Growth &Differentiation, Volume 68, Issue 3, April 2026.
ABSTRACT Three‐dimensional (3D) genome organization is dynamically restructured during early vertebrate development, yet how chromatin domains are established remains poorly understood. In particular, the contribution of individual cohesin regulators to this process during embryogenesis is unclear.
Shinra Ikeda, Hiroyuki Takeda, Ryohei Nakamura   +2 more
wiley   +1 more source

Identification of a novel CTCF mutation responsible for syndromic intellectual disability – a case report

BMC Medical Genetics, 2017
Background Autosomal dominant mental retardation 21 (MRD21) is a very rare condition, characterized by short stature, microcephaly, mild facial dysmorphisms and intellectual disability that ranged from mild to severe.
Fatma Bastaki, Pratibha Nair, Madiha Mohamed, Ethar Mustafa Malik, Mustafa Helmi, Mahmoud Taleb Al-Ali, Abdul Rezzak Hamzeh   +6 more
doaj   +1 more source

NF-κB Subtypes Regulate CCCTC Binding Factor Affecting Corneal Epithelial Cell Fate [PDF]

Journal of Biological Chemistry, 2010
CCCTC binding factor (CTCF) controls DNA imprinting, insulates important gene expression, and mediates growth factor- and stress-induced cell fate. However, regulatory mechanisms involved in intracellular CTCF activity are largely unknown. In this study, we show that epidermal growth factor (EGF)-induced increase and UV stress-induced decrease in CTCF ...
Luo, Lu, Ling, Wang, Tie, Li, Jie, Wang
openaire   +2 more sources

Hypoxia regulates Th17/Treg balance by altering chromatin accessibility and gene expression

The FEBS Journal, Volume 293, Issue 8, Page 2393-2416, April 2026.
T‐cell differentiation into Th17 or iTreg cells is key to inflammation control. Integrated RNA‐seq and ATAC‐seq analyses reveal that hypoxia induces more extensive gene expression changes in iTreg cells. Elevated levels of Hif1a and Stat3, along with increased accessibility to key transcription factor motifs, may predispose these cells toward ...
Mariana Cázares‐Olivera, Shiyang Song, Sofia Ylinen, Talha Qureshi, Bin Li, Zhi Chen   +5 more
wiley   +1 more source

Depletion of CTCF disrupts PSG gene expression in the human trophoblast cell line Swan 71

FEBS Open Bio, 2021
Pregnancy‐specific glycoproteins (PSGs) are fetal proteins secreted by the placenta during pregnancy. The PSG level in maternal serum is an indicator of risk for pregnancy complications.
Da Som Jeong, Myoung Hee Kim, Ji‐Yeon Lee   +2 more
doaj   +1 more source

Chromatin Topology Reconfiguration Orchestrates Thermotolerant Male Fertility via GhAL5 in Cotton

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This study investigates cotton’s high‐temperature (HT) response using multi‑omics. Dynamic 3D genome changes drive expression bias affecting male fertility. The tolerant line shows controlled chromatin dynamics, while the sensitive line exhibits overactivation.
Yanlong Li, Jing Yang, Weiran Wang, Chunyang Zuo, Liuling Pei, Yizan Ma, Rui Zhang, Yaru Fan, Huanhuan Ma, Yawei Li, Ruizhen Liu, Shuangxia Jin, Longfu Zhu, Jie Kong, Xianlong Zhang, Ling Min   +15 more
wiley   +1 more source