Results 21 to 30 of about 5,303,548 (144)

CTCF puts a new twist on UV damage and repair in skin cancer

Molecular & Cellular Oncology, 2021
Somatic mutations in skin cancers are highly enriched at binding sites for CCCTC-binding factor (CTCF). We have discovered that CTCF binding alters the DNA structure to render it more susceptible to UV damage. Elevated UV damage formation at CTCF binding
Bastian Stark, Gregory M. K. Poon, John J. Wyrick   +2 more
doaj   +1 more source

Cohesin-Mediated Chromatin Interactions and Autoimmunity

Frontiers in Immunology, 2022
Proper physiological functioning of any cell type requires ordered chromatin organization. In this context, cohesin complex performs important functions preventing premature separation of sister chromatids after DNA replication. In partnership with CCCTC-
Venkataragavan Chandrasekaran, Nina Oparina, Maria-Jose Garcia-Bonete, Caroline Wasén, Caroline Wasén, Malin C. Erlandsson, Eric Malmhäll-Bah, Karin M. E. Andersson, Maja Jensen, Sofia T. Silfverswärd, Gergely Katona, Maria I. Bokarewa, Maria I. Bokarewa   +12 more
doaj   +1 more source

Remote Memory and Cortical Synaptic Plasticity Require Neuronal CCCTC-Binding Factor (CTCF). [PDF]

J Neurosci, 2018
The molecular mechanism of long-term memory has been extensively studied in the context of the hippocampus-dependent recent memory examined within several days.
Kim S, Yu NK, Shim KW, Kim JI, Kim H, Han DH, Choi JE, Lee SW, Choi DI, Kim MW, Lee DS, Lee K, Galjart N, Lee YS, Lee JH, Kaang BK.   +15 more
europepmc   +2 more sources

Critical Role for the Transcription Regulator CCCTC-Binding Factor in the Control of Th2 Cytokine Expression

, 2009
Differentiation of naive CD4(+) cells into Th2 cells is accompanied by chromatin remodeling at the Th2 cytokine focus allowing the expression of the IL-4, IL-5, and IL-13 genes.
Ribeiro de Almeida, Claudia, Heath, HE (Helen Elizabeth), Hendriks, Rudi, Krpic, S (Sanja), van de Nobelen, S (Suzanne), Galjart, Niels; id_orcid, Grosveld, Frank, Sleutels, Frank, Dingjan, Gemma, Bergen, Ingrid, Hamburg, Jan piet   +10 more
core   +10 more sources

CTCF, Cohesin, and Chromatin in Human Cancer [PDF]

Genomics & Informatics, 2017
It is becoming increasingly clear that eukaryotic genomes are subjected to higher-order chromatin organization by the CCCTC-binding factor/cohesin complex.
Sang-Hyun Song, Tae-You Kim
doaj   +1 more source

Expression analysis of p50-associated COX-2 extragenic RNA and NF-Kappa B Interacting long non-coding RNA in multiple sclerosis patients

Journal of Pharmaceutical and Biomedical Analysis Open, 2023
Inflammatory long non-coding RNAs (lncRNAs) including PACER (p50-associated COX-2 extragenic RNA) and NKILA (NF-Kappa B Interacting long non-coding RNA) and have recently emerged as essential regulators in immune and inflammation pathways in patients ...
Zeinab Shirvani-Farsani, Mina Rezaei, Zahra Abedi Kichi, Mehrdad Behmanesh, Shirin Farivar   +4 more
doaj   +1 more source

CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair

Nature Communications, 2020
Myelination by Schwann cells (SC) in the peripheral nervous system is essential for motor function, and dysregulation of SC myelination can lead to various neuropathies.
Jincheng Wang, Jiajia Wang, Lijun Yang, Chuntao Zhao, Laiman Natalie Wu, Lingli Xu, Feng Zhang, Qinjie Weng, Michael Wegner, Q. Richard Lu   +9 more
doaj   +1 more source

Epigenetic and transcriptional analysis reveals a core transcriptional program conserved in clonal prostate cancer metastases

Molecular Oncology, 2021
The epigenomic regulation of transcriptional programs in metastatic prostate cancer is poorly understood. We studied the epigenomic landscape of prostate cancer drivers using transcriptional profiling and ChIP‐seq in four clonal metastatic tumors derived
Tesa M. Severson, Yanyun Zhu, Angelo M. De Marzo, Tracy Jones, Jonathan W. Simons, William G. Nelson, Srinivasan Yegnasubramanian, Matthew L. Freedman, Lodewyk Wessels, Andries M. Bergman, Michael C. Haffner, Wilbert Zwart   +11 more
doaj   +1 more source

CTCF (CCCTC-binding factor (zinc finger protein)) [PDF]

, 2013
Review on CTCF (CCCTC-binding factor (zinc finger protein)), with data on DNA, on the protein encoded, and where the gene is ...
Piette, J
core   +1 more source

CCCTC-binding Factor (Ctcf) is Required for Mouse Cardiovascular Development [PDF]

, 2016
Disruption of transcriptional programs controlling development of the cardiovascular system can cause congenital cardiovascular disease. These programs are tightly regulated by chromatin regulators that alter gene expression via formation of active or ...
Roy, Anna
core   +2 more sources