CCCTC-binding factor controls the homeostatic maintenance and migration of Langerhans cells [PDF]
Journal of Allergy and Clinical Immunology, 2015 Langerhans cells (LCs) are skin-resident dendritic cells (DCs) that orchestrate skin immunity. CCCTC-binding factor (CTCF) is a highly conserved DNA-binding protein that regulates higher-order chromatin organization and is involved in various gene regulation processes.We sought to clarify a possible role for CTCF in LC homeostasis and function in vivo ...
Tae-Gyun Kim +2 more
exaly +4 more sources
CCCTC-binding factor is essential to the maintenance and quiescence of hematopoietic stem cells in mice. [PDF]
Exp Mol Med, 2017 Hematopoiesis involves a series of lineage differentiation programs initiated in hematopoietic stem cells (HSCs) found in bone marrow (BM). To ensure lifelong hematopoiesis, various molecular mechanisms are needed to maintain the HSC pool. CCCTC-binding factor (CTCF) is a DNA-binding, zinc-finger protein that regulates the expression of its target gene
Kim TG +6 more
europepmc +5 more sources
CCCTC-binding factor: to loop or to bridge. [PDF]
Cell Mol Life Sci, 2009 Eukaryotic genomes have complex spatial organization in the nucleus. The factors and the mechanisms involved in this organization remain an enigma. Among the many proteins implicated in such a role, the ubiquitous Zn-finger protein CTCF stands out. Here we summarize the evidence placing CTCF in the enviable position of a master organizer of the genome.
Zlatanova J, Caiafa P.
europepmc +3 more sources
Mitotic phosphorylation of CCCTC-binding factor (CTCF) reduces its DNA binding activity. [PDF]
FEBS Open Bio, 2017 During mitosis, higher order chromatin structures are disrupted and chromosomes are condensed to achieve accurate chromosome segregation. CCCTC‐binding factor (CTCF) is a highly conserved and ubiquitously expressed C2H2‐type zinc finger protein which is considered to be involved in epigenetic memory through regulation of higher order chromatin ...
Sekiya T +4 more
europepmc +4 more sources
Impact of human sepsis on CCCTC-binding factor associated monocyte transcriptional response of Major Histocompatibility Complex II components. [PDF]
PLoS ONE, 2018 BACKGROUND:Antigen presentation on monocyte surface to T-cells by Major Histocompatibility Complex, Class II (MHC-II) molecules is fundamental for pathogen recognition and efficient host response.
Benedikt Hermann Siegler +6 more
doaj +2 more sources
Remote Memory and Cortical Synaptic Plasticity Require Neuronal CCCTC-Binding Factor (CTCF). [PDF]
J Neurosci, 2018 The molecular mechanism of long-term memory has been extensively studied in the context of the hippocampus-dependent recent memory examined within several days. However, months-old remote memory maintained in the cortex for long-term has not been investigated much at the molecular level yet.
Kim S +15 more
europepmc +4 more sources
Pax6 regulation in retinal cells by CCCTC binding factor. [PDF]
Invest Ophthalmol Vis Sci, 2006 A previous study demonstrated that CTCF (CCCTC binding factor) regulates homeobox Pax6 gene expression in early embryonic stages and plays a dominant role in eye development. The purpose of the present study was to explore further the mechanism of CTCF controlling Pax6 gene expression in human retinoblastoma (Rb) cells and in the development of chicken
Li T, Lu Z, Lu L.
europepmc +4 more sources
CCCTC-binding factor regulates splicing factor proline and glutamine-rich to promote malignant growth of osteosarcoma. [PDF]
Am J Transl ResCCCTC-binding factor (CTCF) is a candidate tumor regulatory gene that encodes multifunctional transcription factors. While its role in various cancers has been studied, its function and mechanism in osteosarcoma were uncertain. Previous studies have identified splicing factor proline and glutamine-rich (SFPQ) as an oncogene in osteosarcoma ...
Li D +10 more
europepmc +3 more sources
CTCF (CCCTC-binding factor (zinc finger protein)) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on CTCF (CCCTC-binding factor (zinc finger protein)), with data on DNA, on the protein encoded, and where the gene is implicated.
exaly +5 more sources
Variable Extent of Lineage-Specificity and Developmental Stage-Specificity of Cohesin and CCCTC-Binding Factor Binding Within the Immunoglobulin and T Cell Receptor Loci [PDF]
Frontiers in Immunology, 2018 CCCTC-binding factor (CTCF) is largely responsible for the 3D architecture of the genome, in concert with the action of cohesin, through the creation of long-range chromatin loops.
Salvatore Loguercio +4 more
doaj +2 more sources