CCCTC-Binding Factor Locks Premature IgH Germline Transcription and Restrains Class Switch Recombination [PDF]
Frontiers in Immunology, 2017 In response to antigenic stimulation B cells undergo class switch recombination (CSR) at the immunoglobulin heavy chain (IgH) to replace the primary IgM/IgD isotypes by IgG, IgE, or IgA.
Ester Marina-Zárate +2 more
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Characterization of a new CCCTC-binding factor binding site as a dual regulator of Epstein-Barr virus latent infection. [PDF]
PLoS Pathogens, 2023 Distinct viral gene expression characterizes Epstein-Barr virus (EBV) infection in EBV-producing marmoset B-cell (B95-8) and EBV-associated gastric carcinoma (SNU719) cell lines.
Sun Hee Lee +11 more
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Expression of CCCTC‐binding factor (CTCF) is linked to poor prognosis in prostate cancer [PDF]
Molecular Oncology, 2020 The chromatin‐organizing factor CCCTC‐binding factor (CTCF) is involved in transcriptional regulation, DNA‐loop formation, and telomere maintenance.
Doris Höflmayer +23 more
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Binding of CCCTC-Binding Factor (CTCF) to the Minute Virus of Mice Genome Is Important for Proper Processing of Viral P4-Generated Pre-mRNAs [PDF]
Viruses, 2020 Specific chromatin immunoprecipitation of salt-fractionated infected cell extracts has demonstrated that the CCCTC-binding factor (CTCF), a highly conserved, 11-zinc-finger DNA-binding protein with known roles in cellular and viral genome organization ...
Maria Boftsi +3 more
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CCCTC-Binding Factor Acts as a Heterochromatin Barrier on Herpes Simplex Viral Latent Chromatin and Contributes to Poised Latent Infection [PDF]
mBio, 2018 Herpes simplex virus 1 (HSV-1) establishes latent infection in neurons via a variety of epigenetic mechanisms that silence its genome. The cellular CCCTC-binding factor (CTCF) functions as a mediator of transcriptional control and chromatin organization ...
Jennifer S. Lee +5 more
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The relationship between transcription initiation RNAs and CCCTC-binding factor (CTCF) localization [PDF]
Epigenetics & Chromatin, 2011 Background Transcription initiation RNAs (tiRNAs) are nuclear localized 18 nucleotide RNAs derived from sequences immediately downstream of RNA polymerase II (RNAPII) transcription start sites.
Taft Ryan J +3 more
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Impact of human sepsis on CCCTC-binding factor associated monocyte transcriptional response of Major Histocompatibility Complex II components. [PDF]
PLoS ONE, 2018 BACKGROUND:Antigen presentation on monocyte surface to T-cells by Major Histocompatibility Complex, Class II (MHC-II) molecules is fundamental for pathogen recognition and efficient host response.
Benedikt Hermann Siegler +6 more
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Variable Extent of Lineage-Specificity and Developmental Stage-Specificity of Cohesin and CCCTC-Binding Factor Binding Within the Immunoglobulin and T Cell Receptor Loci [PDF]
Frontiers in Immunology, 2018 CCCTC-binding factor (CTCF) is largely responsible for the 3D architecture of the genome, in concert with the action of cohesin, through the creation of long-range chromatin loops.
Salvatore Loguercio +4 more
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SPOP-mediated K27-linked non-degradative ubiquitination of KCNN3 suppressing HCC progression via the CTCF-SATB1 axis [PDF]
Cell Death and DiseaseThe metastasis of hepatocellular carcinoma (HCC) cells remains a major obstacle to achieving favorable clinical outcomes, yet the underlying molecular mechanisms are still not fully understood.
Ziqing Zhan +16 more
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The HSV-1 encoded CCCTC-binding factor, CTRL2, impacts the nature of viral chromatin during HSV-1 lytic infection. [PDF]
PLoS PathogensHSV-1 genomes are rapidly heterochromatinized following entry by host cells to limit viral gene expression. Efficient HSV-1 genome replication requires mechanisms that de-repress chromatin associated with the viral genome.
Pankaj Singh +4 more
doaj +2 more sources