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CCCTC‐binding factor meets poly(ADP‐ribose) polymerase‐1
Journal of Cellular Physiology, 2009AbstractCCCTC‐binding factor (CTCF) is a ubiquitous Zn‐finger‐containing protein with numerous recognized functions, including, but not limited to, gene activation and repression, enhancer‐blocking, X‐chromosome inactivation, and gene imprinting. It is believed that the protein performs such a variety of functions by interacting with an array of very ...
CAIAFA, Paola, Jordanka Zlatanova
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Deep Learning of Sequence Patterns for CCCTC-Binding Factor-Mediated Chromatin Loop Formation
Journal of Computational Biology, 2021The three-dimensional (3D) organization of the human genome is of crucial importance for gene regulation, and the CCCTC-binding factor (CTCF) plays an important role in chromatin interactions. However, it is still unclear what sequence patterns in addition to CTCF motif pairs determine chromatin loop formation.
Shuzhen Kuang, Liangjiang Wang
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CCCTC-binding factor regulates the development and function of dendritic cells
The Journal of Immunology, 2019Abstract Dendritic cells (DCs) are professional antigen presenting cells, which present antigen to cognate T cells. DC activation through diverse toll-like receptors is prerequisite for triggering efficient immune responses to foreign antigens.
Bobae Yang +3 more
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CCCTC-Binding Factor Transcriptionally Targets Wdr5 to Mediate Somatic Cell Reprogramming
Stem Cells and Development, 2017It was previously reported that WD repeat domain 5 (Wdr5), a core member of the mammalian Trithorax complex, is a key regulator for the maintenance of embryonic stem (ES) cell pluripotency and somatic cell reprogramming. However, it remains unclear whether other factors are also involved in this process. Here, we show that CTCF is an upstream regulator
Feng, Wang +9 more
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The role of CCCTC binding factor (CTCF) in epithelial to mesenchymal transition (EMT)
The FASEB Journal, 2017The process of Epithelial to Mesenchymal transition (EMT) plays a major role in cancer metastasis. TGF‐β or EGF signaling pathways can trigger EMT, which involves a cell state transition from an attached, epithelial state to a migratory, mesenchymal phenotype.
Atrayee Bhattacharya +2 more
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Long noncoding RNA HOTTIP cooperates with CCCTC-binding factor to coordinate HOXA gene expression
Biochemical and Biophysical Research Communications, 2018The spatiotemporal control of HOX gene expression is dependent on positional identity and often correlated to their genomic location within each loci. Maintenance of HOX expression patterns is under complex transcriptional and epigenetic regulation, which is not well understood. Here we demonstrate that HOTTIP, a lincRNA transcribed from the 5' edge of
Feng, Wang +6 more
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Epigenetic Alterations Associated With CCCTC-Binding Factor Deregulation in Prostate Cancer
2012Abstract : CCCTC-binding factor (CTCF) is a widely expressed 11-zinc finger nuclear protein. CTCF plays an important role in epigenetic regulation by establishing, maintaining epigenetic states in the genome, preventing the spread of DNA methylation, and maintaining methylation-free zones important in gene transcription.
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The role of CCCTC-binding factor (CTCF) in genomic imprinting, development, and reproduction.
Biology of reproduction, 2015CCCTC-binding factor (CTCF) is the major protein involved in insulator activity in vertebrates, with widespread DNA binding sites in the genome. CTCF participates in many processes related to global chromatin organization and remodeling, contributing to the repression or activation of gene transcription.
Maurício M, Franco +2 more
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Epigenetic Alterations Associated With CCCTC-Binding Factor Deregulation in Prostate Cancer
2011Abstract : CCCTC-binding factor (CCTF) is a widely expressed 11-zinc finger nuclear protein. CTCF plays an important role in epigenetic regulation by establishing, maintaining epigenetic states in the genome, preventing the spread of DNA methylation, and maintaining methylation-free zones important in gene transcription.
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