Results 141 to 150 of about 11,478 (172)

Regulatory role and translational potential of CCL11 in liver fibrosis

Hepatology, 2023
Background and Aims: Myofibroblasts are considered the major effector cell type of liver fibrosis and primarily derived from hepatic stellate cells (HSCs). In the present study, we investigated the contribution of C-C motif chemokine (CCL11) to HSC-myofibroblast trans-differentiation and its implication in liver fibrosis.
Ming Kong, Wenhui Dong, Aoqi Kang, Yameng Kuai, Tongchang Xu, Zhiwen Fan, Longqing Shi, Donglin Sun, Yunjie Lu, Zilong Li, Yong Xu   +10 more
openaire   +2 more sources

Association of CCL11, CCL24 and CCL26 with primary biliary cholangitis

International Immunopharmacology, 2019
CCL11, CCL24 and CCL26 are potent chemokines for eosinophils. Since there has been no study reporting the association serum CCL11, CCL24 and CCL26 with fibrotic progression of PBC, the aim of this study is to explore the association.One hundred and eight PBC patients, 52 patients with chronic hepatitis B (CHB) and 50 healthy controls (HC) were ...
Zaixing Yang, , Renqian Zhong
exaly   +3 more sources

CCL11 exacerbates colitis and inflammation-associated colon tumorigenesis

Oncogene, 2021
CCL11, also known as eotaxin-1, is described as an eosinophil chemoattractant, which has been implicated in allergic and Th2 inflammatory diseases. We have reported that CCL11 is significantly increased in the serum of inflammatory bowel disease (IBD) patients, colonic eosinophils are increased and correlate with tissue CCL11 levels in ulcerative ...
Dina Polosukhina, Kshipra Singh, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Dana M. Hardbower, M. Blanca Piazuelo, M. Kay Washington, Alain P. Gobert, Keith T. Wilson, Lori A. Coburn   +10 more
openaire   +3 more sources

CCL11 promotes angiogenic activity by activating the PI3K/Akt pathway in HUVECs

Journal of Receptor and Signal Transduction Research, 2017
CCR3, the receptor for CCL11, is expressed on the surface of immune cells and even on non-immune cells. CCL11-CCR3 interactions can promote cell migration and proliferation. In this study, we investigated the effect of CCL11 on angiogenesis in HUVECs and also examined the molecular mechanisms of this process.
Jun Young Park, Won Gil Cho, Byung Pil Cho   +2 more
exaly   +4 more sources

Targeting CCL11 in the treatment of ovarian cancer

Expert Opinion on Therapeutic Targets, 2010
The chemokine network, comprised of mediators of inflammation, has been implicated in the development of a number of human cancers. The eosinophil chemoattractant CCL11 was recently shown to play a role in the development of ovarian cancer. Here we review findings regarding CCL11 and discuss its use as a target in the treatment of ovarian cancer.We ...
Brian M, Nolen, Anna E, Lokshin
openaire   +2 more sources

CCL11 as a potential diagnostic marker for asthma?

Journal of Asthma, 2014
Asthma is an inflammatory airway disease characterized by airway eosinophilia, in which CCL11 (eotaxin) plays a crucial role. The aim of study is to determine the elevation of CCL11 levels in bronchoalveolar lavage fluid (BALF), blood, exhaled breath condensate (EBC) and sputum in asthma patients and to identify which medium yields the most significant
Dandan, Wu, Ji, Zhou, Hui, Bi, Lingling, Li, Wei, Gao, Mao, Huang, Ian M, Adcock, Peter J, Barnes, Xin, Yao   +8 more
openaire   +2 more sources

Increased serum levels of CCL11/eotaxin in schizophrenia

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2008
Inflammatory and immune alterations occur and may be relevant in patients with schizophrenia. Chemokines are a subgroup of cytokines that play a major role in the recruitment of determined subsets of leukocytes into tissues. To date no study has evaluated whether levels of chemokines are altered in patients with schizophrenia.To evaluate serum levels ...
Antonio Lucio, Teixeira, Helton Jose, Reis, Rodrigo, Nicolato, Gustavo, Brito-Melo, Humberto, Correa, Mauro Martins, Teixeira, Marco Aurelio, Romano-Silva   +6 more
openaire   +2 more sources

Equine CCL11 induces eosinophil cytoskeletal reorganization and activation

Inflammation Research, 2006
To assess the biological effects of purified recombinant equine CCL11 on equine eosinophil function.Following stimulation of eosinophils from normal horses, the polymerised form of actin was measured by flow cytometry using fluorescently labelled phalloidin. Migration was determined in a 96 well plate chemotaxis assay using 8 microm pore membranes, and
M C, Weston, M E, Collins, F M, Cunningham   +2 more
openaire   +2 more sources

Blackcurrant anthocyanins modulate CCL11 secretion and suppress allergic airway inflammation

Molecular Nutrition and Food Research, 2017
CCL11, a chemokine, is linked to the early development of airways eosinophilia in allergic asthma. Therefore, CCL11 production is a target for abrogating eosinophilic-driven airway inflammation. Blackcurrants are high in compounds that regulate inflammation, particularly anthocyanins.
Tafadzwa Nyanhanda, Odette Shaw, Roger Hurst   +2 more
exaly   +4 more sources

Association of CCL11 promoter polymorphisms with schizophrenia in a Korean population

Gene, 2018
Immunological alterations and dysregulation of the inflammatory response have been suggested to play a crucial role in schizophrenia pathophysiology. Growing evidence supports the involvement of chemokines in brain development, thus many chemokines have been studied in relation with schizophrenia.
Won Sub Kang, Young Jong Kim, Hae Jeong Park, Su Kang Kim, Jong-Woo Paik, Jong Woo Kim   +5 more
openaire   +2 more sources