Results 151 to 160 of about 11,478 (172)

Decoding the roles of CCL11 in human malignancies and clinical implications

Biochemical Pharmacology
C-C motif chemokine ligand 11 (CCL11), alternatively designated as eotaxin-1, is a low molecular weight chemokine that plays a crucial role in the mediation of allergic inflammation and immune regulation. This is achieved through the recruitment of eosinophils, T helper 2 (Th2) cells, and basophils via its primary receptor, CC chemokine receptor 3 ...
Hongxing Shen
exaly   +3 more sources

Reduced ccl11/eotaxin mediates the beneficial effects of environmental stimulation on the aged hippocampus

Brain, Behavior, and Immunity, 2021
A deterioration in cognitive performance accompanies brain aging, even in the absence of neurodegenerative pathologies. However, the rate of cognitive decline can be slowed down by enhanced cognitive and sensorimotor stimulation protocols, such as environmental enrichment (EE).
Scabia G., Testa G., Scali M., Del Turco S., Desiato G., Berardi N., Sale A., Matteoli M., Maffei L., Maffei M., Mainardi M., Train the Brain Consortium   +11 more
openaire   +3 more sources

Control of extravillous trophoblast function by the eotaxins CCL11, CCL24 and CCL26

Human Reproduction, 2013
What are the effects of the eotaxin group of chemokines (CCL11, CCL24 and CCL26) on extravillous trophoblast (EVT) functions important during uterine decidual vessel remodelling?CCL11, CCL24 and CCL26 can regulate EVT migration, invasion and adhesion, highlighting a potential regulatory role for these chemokines during uterine decidual spiral arteriole
CHAU, SIMON, MURTHI, PADMA, Wong, May, Whitley, Guy StJ, BRENNECKE, SHAUN, KEOGH, ROSEMARY   +5 more
openaire   +2 more sources

Evolution of CCL11: genetic characterization in lagomorphs and evidence of positive and purifying selection in mammals [PDF]

Innate Immunity, 2016
The interactions between chemokines and their receptors are crucial for differentiation and activation of inflammatory cells. CC chemokine ligand 11 (CCL11) binds to CCR3 and to CCR5 that in leporids underwent gene conversion with CCR2. Here, we genetically characterized CCL11 in lagomorphs (leporids and pikas).
Pedro Esteves, Fabiana Neves, Joana Abrantes   +2 more
exaly   +3 more sources

Measurement of eotaxin (CCL11) in induced sputum supernatants: Validation and detection in asthma

Journal of Allergy and Clinical Immunology, 2004
Induced sputum is widely used in asthma research; however, for many mediators, the detection methods have not been validated.We sought to optimize the method of detection of eotaxin, an important chemokine acting through the CCR3 receptor on eosinophils, basophils, and T(H)2 cells.Induced sputum from normal and asthmatic subjects was processed with ...
Hadjicharalambous, Chrystalleni, Dent, Gordon, May, Richard D., Handy, Rachel L.C., Anderson, Ian K., Davies, Donna E., Djukanovic, Ratko   +6 more
openaire   +3 more sources

Eotaxin/CCL11 Is a Negative Regulator of Neutrophil Recruitment in a Murine Model of Endotoxemia

Experimental and Molecular Pathology, 2002
Eotaxin/CCL11 is a chemokine that has been primarily characterized with respect to its eosinophil chemoattractant activity. However, the broad tissue expression of eotaxin/CCL11 suggests that it may have other unknown activities. We have used a murine model of endotoxemia to study the role of eotaxin/CCL11 in neutrophil recruitment. We demonstrate that
Sara S, Cheng, Nicholas W, Lukacs, Steven L, Kunkel   +2 more
openaire   +2 more sources

Cannabis use is associated with increased CCL11 plasma levels in young healthy volunteers

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2013
Cannabis is a widely used recreational drug. Its effect on human health and psychosis remains controversial. In this study, we aimed to explore the possibility that cannabis use influenced CCL11 plasma levels. Increased CCL11 chemokine has been reported in schizophrenia and cannabis is a known trigger of schizophrenia.
Emilio, Fernandez-Egea, Linda, Scoriels, Swathi, Theegala, Maria, Giro, Susan E, Ozanne, Keith, Burling, Peter B, Jones   +6 more
openaire   +2 more sources

Serum CCL11 level is associated with radiographic spinal damage in patients with ankylosing spondylitis

Rheumatology International, 2018
The clinical significance of C-C motif chemokine11 (CCL11) in bone metabolism in ankylosing spondylitis (AS) is not clearly elucidated. Thus, this cross-sectional study aimed to compare serum levels of CCL11 between patients with AS and healthy controls and to investigate the relationship between serum levels of CCL11 and radiographic spinal damage in ...
Dong Hyun Sohn, Hoim Jeong, Jong Seong Roh, Han-Na Lee, Eunsung Kim, Jung Hee Koh, Seung-Geun Lee   +6 more
openaire   +2 more sources

Eotaxin (CCL11) enhances mediator release from human basophils

Allergy, 2021
Yuki Suzuki, Masao Yamaguchi, Miki Mori, Naoya Sugimoto, Maho Suzukawa, Motoyasu Iikura, Hiroyuki Nagase, Ken Ohta   +7 more
openaire   +2 more sources

Eotaxin-1 (CCL11) in neuroinflammatory disorders and possible role in COVID-19 neurologic complications

Acta Neurologica Belgica, 2022
Mahin Behzadifard, Donya Nazarinia
exaly