Results 81 to 90 of about 11,820 (181)

Inflammatory mediators and dual depression: Potential biomarkers in plasma of primary and substance-induced major depression in cocaine and alcohol use disorders.

PLoS ONE, 2019
Major depressive disorder (MDD) is the most prevalent comorbid mental disorder among people with substance use disorders. The MDD can be both primary and substance-induced and its accurate diagnosis represents a challenge for clinical practice and ...
Nuria García-Marchena, Marta Barrera, Joan Ignasi Mestre-Pintó, Pedro Araos, Antonia Serrano, Clara Pérez-Mañá, Esther Papaseit, Francina Fonseca, Juan Jesús Ruiz, Fernando Rodríguez de Fonseca, Magí Farré, Francisco Javier Pavón, Marta Torrens   +12 more
doaj   +1 more source

Systemic pirfenidone treatment fails to mitigate fibrosis and compromises functional recovery in a porcine model of volumetric muscle loss

Experimental Physiology, EarlyView.
Abstract Repurposing clinically approved antifibrotic agents presents a potential near‐term therapeutic strategy to mitigate the extensive fibrotic scarring that follows severe volumetric muscle loss (VML) injury and inhibits functional recovery. We hypothesized that daily oral administration of pirfenidone, an FDA‐approved antifibrotic, would mitigate
Jessica M. Motherwell, Ondine Eken, Claudia E. Hernandez, Christopher L. Dearth, Stephen M. Goldman   +4 more
wiley   +1 more source

Validity of serum CCL11 (Eotaxin-1) and interleukin-13 as prognostic biomarkers in hepatitis C virus induced liver disease

The Egyptian Journal of Internal Medicine
Background Hepatitis C virus (HCV) is the main cause of chronic liver disease (CLD), which affects more than 50 million people around the world. Persistent immune dysregulation promotes hepatocellular damage, fibrotic remodeling and carcinogenesis ...
Nasser Abdallah, Khaled Hussain, Akram Deghady, Samar Raky, Marwa Deif   +4 more
doaj   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Piezoelectric Nanofibrous Scaffolds for Promoting the Growth of Spiral Ganglion Neurons via Acoustic Stimulation

Smart Medicine, Volume 5, Issue 5, October 2026.
The piezoelectric nanofibrous scaffolds containing PANI, PLLA and Gelatin exhibited biomimetic structure, components, and piezoelectricity. Benefiting from the oriented nanofibers and electrical stimulation induced by wireless acoustic excitation, the SGNs cultured on the scaffolds showed enhanced neurite alignment, extension, and growth cone ...
Dongyu Xu, Cuntu Cheng, Shan Xu, Chuan Bu, Shuangba He, Sizhe Song, Yu Wang, Busheng Tong, Yangnan Hu, Huan Wang, Renjie Chai   +10 more
wiley   +1 more source

Peripheral chemokine levels in women with recurrent major depression with suicidal ideation Níveis periféricos de quimiocina em mulheres com depressão maior com ideação suicida

Brazilian Journal of Psychiatry, 2012
OBJECTIVE: To compare serum levels of MCP-1/CCL2, RANTES/CCL5, and Eotaxin/CCL11 between female patients with recurrent major depressive disorder (MDD) and healthy controls, verifying if there is a difference in the levels of these mediators between ...
Rodrigo Grassi-Oliveira, Elisa Brieztke, Antônio Teixeira, Júlio Carlos Pezzi, Márcio Zanini, Rodrigo Pestana Lopes, Moisés Evandro Bauer   +6 more
doaj   +1 more source

Genetic fusion of CCL11 to antigens enhances antigenicity in nucleic acid vaccines and eradicates tumor mass through optimizing T-cell response

Molecular Cancer
Nucleic acid vaccines have shown promising potency and efficacy for cancer treatment with robust and specific T-cell responses. Improving the immunogenicity of delivered antigens helps to extend therapeutic efficacy and reduce dose-dependent toxicity ...
Hailong Qi, Zhongjie Sun, Tianle Gao, Yanling Yao, Yu Wang, Weiwei Li, Xudong Wang, Xiaofang Wang, Defang Liu, Jian-Dong Jiang   +9 more
doaj   +1 more source

Actividad antioxidante de Jatropha dioica Sessé y acoplamiento molecular de jatrofatriona con CCL11/CCR3

Ecosistemas y Recursos Agropecuarios
Las heridas cutáneas crónicas se mantienen en un entorno de estrés oxidativo e inflamación persistente, en el que la señalización CCL11-CCR3 puede interferir con la reparación.
Rosa Isela Gómez-Gómez, Erick Sierra-Campos, Mónica Andrea Valdez-Solana, Juan Manuel de Jesús Favela-Hernández, Joaquín Ávalos-Soto, Miguel Ángel Téllez-López   +5 more
doaj   +1 more source

Lonicera japonica‐Derived Nanovesicles Ameliorate Acute Lung Injury by Suppressing Neutrophil Extracellular Traps Formation in Mice

Advanced Healthcare Materials, Volume 15, Issue 33, 4 September 2026.
(A) Isolation and purification of LDNVs. (B) Establishment of the ALI model and LDNVs delivery. (C) Therapeutic mechanisms of LDNVs in treating ALI. This scheme figure was drawn by Figdraw, ID: IUIIO21222. ABSTRACT Acute lung injury (ALI) is a lethal respiratory disease.
Xi Lin, Jian Lin, Yezi Zhang, Xinyan Zhang, Xinghua Liu, Hongying Cao, Huan Shen, Jianming Liang, Zhenhua Dai, Siyuan Xu, Xingdong Lin   +10 more
wiley   +1 more source

Citric Acid‑Assisted Microwave Degradation of Hericium erinaceus β‑Glucan Enhances Gastroprotective Efficacy

Food Frontiers, Volume 7, Issue 5, September 2026.
A citric acid‐assisted microwave degradation strategy was provided to enhance the therapeutic potential of H. erinaceus β‐glucan for gastric protection. ABSTRACT The gastroprotective bioactivity of high molecular‐weight β‐glucan from Hericium erinaceus is often constrained by its poor solubility and low oral bioavailability.
Peng Liu, Minjie Du, Zhong Zhang, Wanchao Chen, Wen Li, Zhengpeng Li, Dapeng Sun, Wenjian Yang, Di Wu, Yan Yang   +9 more
wiley   +1 more source