Results 61 to 70 of about 4,498 (153)

IL-33 reduces tumor growth in models of colorectal cancer with the help of eosinophils

OncoImmunology, 2020
In many types of cancer, presence of eosinophils in tumors correlate with an improved disease outcome. In line with this, activated eosinophils have been shown to reduce tumor growth in colorectal cancer (CRC). Interleukin (IL)-33 has recently emerged as
Melanie Kienzl, Carina Hasenoehrl, Paulina Valadez-Cosmes, Kathrin Maitz, Arailym Sarsembayeva, Eva Sturm, Akos Heinemann, Julia Kargl, Rudolf Schicho   +8 more
doaj   +1 more source

Inhaled Angiopoietin‐Like 4 Antisense Oligonucleotide Therapy for Lung Injury and Fibrosis

Advanced Science, Volume 13, Issue 23, 23 April 2026.
Inhaled antisense oligonucleotides targeting ANGPTL4 attenuate inflammation, preserve barrier integrity, and reduce fibrosis in both infectious and sterile lung injury models. Integrated transcriptomic analysis reveals a conserved ANGPTL4‐regulated gene network coordinating hypoxic, inflammatory, apoptotic, and stress‐response pathways.
Haiyang Fan, Yuanyang Tan, Junhang Zhang, Xiaoya Liu, Jing Qu, Damien Chua, Hong Sheng Cheng, Joseph Han Sol Kim, Yu Xuan Liu, Changfei Qin, Yingzi Liu, Dezhi Li, Jikang Qiu, Mengshi Chi, Mingmin Bi, Qiwei Zhang, Yun Li, Masoumeh Motamedi Joibari, Stefan K Nilsson, Nguan Soon Tan, Yunping Fan, Liang Li   +21 more
wiley   +1 more source

Synergistic Activation of Immunogenic Cell Death and the cGAS–STING Pathway by Engineered Zinc/Manganese‐Based Metal–Organic Framework Nanoplatforms for Colon Cancer Immunotherapy

Advanced Science, Volume 13, Issue 19, 2 April 2026.
A zinc/manganese (Zn/Mn)‐based metal‐organic framework (MOF) loaded with the STING agonist c‐di‐AMP diammonium (denoted AMP@Zn/Mn‐MOF) was developed to synergistically activate the cGAS‐STING pathway and induce immunogenic cell death. This nanoplatform reprograms the immunosuppressive tumor microenvironment, significantly enhancing anti‐PD‐L1 ...
Bingzi Zhu, Xiaodong Chen, Chang Xu, Xuehua Qian, Binglong Bai, Ji Lin, Wenhai Deng, Xiang Wang, Yuekai Cui, Shengsheng Zhao, Zuoliang Xie, Tao You, Yingpeng Huang, Xian Shen, Xufeng Lu, Weijian Sun   +15 more
wiley   +1 more source

The long noncoding RNA-30162 is regulated by commensal microbiota and modulates CCL24 and ARG1 in macrophages [PDF]

, 2020
Abstract Background Alveolar macrophages (AMs) are the largest number of innate immune cells in the distal lung. AMs have critical roles in maintaining immunological homoeostasis and host defense in the lung and are inherently suppressive. Immune homeostasis depends on the integrity of microbiome, which contribute to appropriate maturation and ...
Yingjie Mu, Wen Chen, Shilian Hu, Min Cheng   +3 more
openaire   +1 more source

Beyond miRNA Cargo Profiles: Anti‐Inflammatory Roles of Extracellular Vesicle‐Enriched miRNAs Derived From Human Intervertebral Disc Cells Unveiled by Functional Testing

Journal of Extracellular Biology, Volume 5, Issue 4, April 2026.
ABSTRACT Intervertebral disc (IVD) degeneration is a leading cause of chronic low back pain and a major contributor to global disability. Understanding the molecular mechanisms underlying this condition is essential for developing targeted therapies. Among these mechanisms, microRNAs (miRNAs) have emerged as critical post‐transcriptional regulators of ...
Li Li, Aiwei Sun, Saber Ghazizadeh, Hadil Al‐Jallad, Kirby Upshaw, Saleh Alfaisali, Jean Ouellet, Peter Jarzem, Hosni Cherif, Lisbet Haglund   +9 more
wiley   +1 more source

Differential and cooperative effects of IL-25 and IL-33 on T helper cells contribute to cryptococcal virulence and brain infection

Scientific Reports, 2023
The epithelial cell-derived cytokines IL-33 and IL-25 are important mediators in driving type-2 inflammation during C. neoformans infection. Nevertheless, the impact of these cytokines in regulating host T helper cell response during C.
Adithap Hansakon, Siranart Jeerawattanawart, Pornpimon Angkasekwinai   +2 more
doaj   +1 more source

AllergoOncology in Review: Harnessing Allergy in the Field of Oncology to Improve Patient Outcomes

Clinical &Experimental Allergy, Volume 56, Issue 4, Page 344-368, April 2026.
ABSTRACT The AllergoOncology field brings together the study of allergic and cancer immune responses, having evolved from early epidemiological studies that reported inverse associations between allergies, IgE and cancer risk. Insights from studying allergic inflammation are revealing previously unappreciated immune mechanisms that confer protective ...
Jakub Zydron, Anishaa Balaji, Jitesh Chauhan, Jack Alder, Xinyi Chen, Anna M. F. Wiegman, Aurelie Poli, Joanna Jacków‐Malinowska, Jack Cheeseman, Daniel I. R. Spencer, James McDonnell, James Spicer, Alexandra J. McCraw, Sophia N. Karagiannis   +13 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, Volume 20, Issue 3, Page 753-778, March 2026.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Serum CCL24 as a Biomarker of Fibrotic and Vascular Disease Severity in Systemic Sclerosis

Arthritis Care & Research
BackgroundSystemic sclerosis (SSc) is a heterogeneous disease, characterized by variable tissue and vascular fibrosis in the context of autoimmune activation. CCL24 (or Eotaxin2) has been shown to promote microangiopathic, proinflammatory, and profibrotic processes in preclinical models of SSc. Here, we study serum CCL24 levels in a real‐life cohort of
De Lorenzis, E., Mor, A., Ross, R.L., Di Donato, S., Aricha, R., Vaknin, I., Del Galdo, F.   +6 more
openaire   +3 more sources

Spironolactone and Fibrosis in Heart Failure Risk: Machine Learning Analysis of HOMAGE Trial Plasma Proteomics

MedComm, Volume 7, Issue 3, March 2026.
In HOMAGE, 276 plasma proteins were profiled using Olink panels. Machine learning algorithms identified galectin‐9 (GAL9), thrombospondin‐2 (THBS2), and NT‐proBNP as predictors of changes in procollagen type I C‐terminal propeptide (PICP) after spironolactone treatment.
Susana Ravassa, Nicolas Girerd, Frank Edelman, Begoña López, João Pedro Ferreira, Daniela Zurkan, Gorka San José, Iñigo Latasa, Pierpaolo Pellicori, Franco Cosmi, Johannes Petutschnigg, Stephane Heymans, Hans‐Peter Brunner‐La Rocca, Burkert Pieske, Christian Delles, Andrew L. Clark, Javier Díez, Faiez Zannad, John G. F. Cleland, Arantxa González, the HOMAGE Trial Committees and Investigators   +20 more
wiley   +1 more source