Results 51 to 60 of about 4,498 (153)

Multiaxial Biophysical Control of Oncogenic Phase Separation by Indoleamines: A Proof‐of‐Concept Synthesis of Landscape‐Level Regulation

Journal of Pineal Research, Volume 78, Issue 4, July 2026.
ABSTRACT Oncogenic condensates act as biophysical sanctuaries that stabilize malignant survival programs. However, a universal regulator capable of orchestrating the integrated biophysical axes governing cellular phase behavior has remained elusive.
Doris Loh, Luiz Gustavo de Almeida Chuffa, Fábio Rodrigues Ferreira Seiva, Russel J. Reiter   +3 more
wiley   +1 more source

Identification of New Soluble Factors Correlated With the Development of Graft Failure After Haploidentical Hematopoietic Stem Cell Transplantation

Frontiers in Immunology, 2021
Graft failure is a severe complication of allogeneic hematopoietic stem cell transplantation (HSCT). The mechanisms involved in this phenomenon are still not completely understood; data available suggest that recipient T lymphocytes surviving the ...
Gerrit Weber, Luisa Strocchio, Francesca Del Bufalo, Mattia Algeri, Daria Pagliara, Claudia Manuela Arnone, Biagio De Angelis, Concetta Quintarelli, Franco Locatelli, Franco Locatelli, Pietro Merli, Ignazio Caruana   +11 more
doaj   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

Influence of viral infection on the relationships between airway cytokines and lung function in asthmatic children

Respiratory Research, 2018
Background Few longitudinal studies examine inflammation and lung function in asthma. We sought to determine the cytokines that reduce airflow, and the influence of respiratory viral infections on these relationships.
Toby C. Lewis, Ediri E. Metitiri, Graciela B. Mentz, Xiaodan Ren, Ashley R. Carpenter, Adam M. Goldsmith, Kyra E. Wicklund, Breanna N. Eder, Adam T. Comstock, Jeannette M. Ricci, Sean R. Brennan, Ginger L. Washington, Kendall B. Owens, Bhramar Mukherjee, Thomas G. Robins, Stuart A. Batterman, Marc B. Hershenson, the Community Action Against Asthma Steering Committee   +17 more
doaj   +1 more source

Development and functional adaptation of intestinal macrophages across the lifespan

Clinical &Translational Immunology, Volume 15, Issue 6, 2026.
This article discusses intestinal macrophage development, including the influence of developmental origins and life stages; ontogeny and functional heterogeneity; preclinical and clinical evidence. Abstract Macrophages of the gastrointestinal system are central regulators of gut development, homeostasis and disease, yet their origin, functional ...
Baha Mustafa, Elisa L Hill‐Yardin, Sarah J Spencer   +2 more
wiley   +1 more source

Aging‐Related Muscle Bmal1 Decline Contributes to Bone Loss in Mice via Enhancing IL‐1α–Mediated Osteoclastogenesis

Aging Cell, Volume 25, Issue 6, June 2026.
Aging‐related decline of muscle Bmal1 drives bone loss in mice by disrupting Hmox1 and increasing IL‐1α, which promotes osteoclast activity. Time‐restricted feeding reestablishes diurnal Hmox1 expression, reduces IL‐1α, and alleviates osteoporosis, offering a potential therapeutic strategy. ABSTRACT Osteoporosis, a common metabolic bone disorder linked
Kai Huang, Jun Qian, Yike Wang, Feng Zhang, Youjia Xu, Qiaocheng Zhai   +5 more
wiley   +1 more source

Single-Cell Profiling Reveals Divergent, Globally Patterned Immune Responses in Murine Skin Inflammation

iScience, 2020
Summary: Inflammatory response heterogeneity has impeded high-resolution dissection of diverse immune cell populations during activation. We characterize mouse cutaneous immune cells by single-cell RNA sequencing, after inducing inflammation using ...
Yale Liu, Christopher Cook, Andrew J. Sedgewick, Shuyi Zhang, Marlys S. Fassett, Roberto R. Ricardo-Gonzalez, Paymann Harirchian, Sakeen W. Kashem, Sho Hanakawa, Jacob R. Leistico, Jeffrey P. North, Mark A. Taylor, Wei Zhang, Mao-Qiang Man, Alexandra Charruyer, Nadejda Beliakova-Bethell, Stephen C. Benz, Ruby Ghadially, Theodora M. Mauro, Daniel H. Kaplan, Kenji Kabashima, Jaehyuk Choi, Jun S. Song, Raymond J. Cho, Jeffrey B. Cheng   +24 more
doaj   +1 more source

Bacillus subtilis Provides Long-Term Protection in a Murine Model of Allergic Lung Disease by Influencing Bacterial Composition

Allergies, 2022
Probiotics are an attractive target for reducing the incidence of allergic disease. Bacillus subtilis is a gut-associated probiotic bacteria that can suppress allergic lung disease; however, it is not clear for how long this protection lasts.
Rosalinda Monroy Del Toro, Ryan Incrocci, Olivia Negris, Shaina McGrath, Julie A. Swartzendruber   +4 more
doaj   +1 more source

COX2+/PDGFRα+ fibroblasts selectively localize near bile ducts and interact with immune cells in early liver fibrosis in mice

Physiological Reports, Volume 14, Issue 10, May 2026.
COX2+PDGFRα+ fibroblasts show selective localization and immune crosstalk in bile duct ligation‐induced liver fibrosis. Abstract Liver fibrosis is a growing global health problem with no effective treatments. PDGFRα‐positive fibroblasts are the main drivers of liver fibrosis, but their cellular heterogeneity is not fully understood.
Momo Goto, Tamaki Kurosawa, Hiroyuki Koike, Noriyuki Kaji, Ichiro Manabe, Taiki Mihara, Takashi Chaen, Yumiko Oishi, Masatoshi Hori   +8 more
wiley   +1 more source

Assessment of the diagnostic accuracy of eotaxin-2 as a marker for preterm prelabour rupture of membranes [PDF]

Scripta Medica
Background/Aim: Preterm pre-labour rupture of the membranes could be caused by the change in local cytokines concentration due to inflammatory or infectious conditions.
Ali Miami Abdul Hassan, Ali Naz Mazin
doaj   +1 more source