Results 121 to 130 of about 63,484 (304)

Levisticum officinale extract protects against CCl4-induced hepatotoxicity through anti-inflammatory, anti-fibrotic, and antioxidant properties in rats

Asian Pacific Journal of Tropical Biomedicine
Objective: To investigate the hepatoprotective effects of Levisticum officinale extract on CCl4-induced hepatotoxicity. Methods: Different doses of Levisticum officinale extract were given orally to rats for 10 days, then rats received a single dose of ...
Nahid Ghaedi, Iran Pouraboli, Mansour Mirtadzadini, Mohammad-mehdi Moeini-aghtaie   +3 more
doaj   +1 more source

Phytolacca dodecandra (Phytolaccaceae) Root Extract Exhibits Antioxidant and Hepatoprotective Activities in Mice with CCl4-Induced Acute Liver Damage

Clinical and Experimental Gastroenterology, 2021
Birhanu Geta Meharie,1 Tewodros Agedew Tunta2 1Department of Pharmacy, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia; 2Department of Pharmacy, College of Medicine and Health Sciences, Arba Minch University, Arba Minch ...
Meharie BG, Tunta TA
doaj  

C‐Terminal Functionalization Methods of Amino Acids, Peptides, and Proteins

Chemistry – A European Journal, EarlyView.
C‐terminal functionalization offers powerful routes to peptide and protein diversification, yet epimerization, hydrolysis, and selectivity remain key challenges. This Review surveys enzymatic, decarboxylative, and condensation strategies, highlighting advances toward chemo‐ and regioselective, protecting‐group‐free, atom‐efficient methods applicable to
Jay Hanssens, Mark Lambers, Romano V. A. Orru, Jordy M. Saya   +3 more
wiley   +1 more source

Taurocholate feeding prevents CCl4-induced damage of large cholangiocytes through PI3-kinase-dependent mechanism

, 2003
: Bile acids are cytoprotective in hepatocytes by activating phosphatidylinositol-3-kinase (PI3-K) and its downstream signal AKT. Our aim was to determine whether feeding taurocholate to CCl4-treated rats reduces cholangiocyte apoptosis and whether this ...
ALVARO, Domenico, GLASER SS, MARUCCI L, MARZIONI M., ALPINI G, FRANCIS H, BENEDETTI A, PHINIZY JL   +7 more
core   +1 more source

Benzylic Oxidation of Pillar[5]Arene: From Homo‐ to Cross‐Conjugated Macrocyclic Systems

Chemistry – A European Journal, EarlyView.
Selective benzylic oxidations of pillar[5]arene have been carried out to generate all the possible oxidized derivatives containing from one up to five carbonyl subunits. Effects resulting from the homo‐ and the cross‐conjugation within this series of compounds have been investigated in details and analyzed with the help of DFT calculations.
Jorge Juan Marco‐Guimbao, Eric Meichsner, Unai Calvo, Michel Holler, Béatrice Delavaux‐Nicot, Jon M. Matxain, Juan Luis Delgado, Jean‐François Nierengarten, Iwona Nierengarten   +8 more
wiley   +1 more source

Properties of Nucleotide Pool and Its Relationship with Differentially Expressed Transcriptome and Fibrosis Progression in CCl4-induced Mice

Journal of Physiological Investigation
The properties and dynamics of small biomolecule pools of a cell or an organ have a significant effect on the metabolism of the related biomacromolecules and the ongoing life process.
Zejing Liu, Jiahao Wu, Xuyang Chen, Lei Mao   +3 more
doaj   +1 more source

Tanshinol ameliorates CCl4-induced liver fibrosis in rats through the regulation of Nrf2/HO-1 and NF-κB/IκBα signaling pathway

, 2018
Rong Wang,* Jing Wang,* Fuxing Song, Shengnan Li, Yongfang Yuan Department of Pharmacy, Shanghai 9th People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China *These authors contributed equally to this work Abstract ...
Li S, Wang R, Song F, Wang J, Yuan Y
core  

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović, Ingrid Tomljanović, Wieke H. Grievink, Diana R. Pereira, Michelle Osse, Peter van Balen, Maria J. Juachon, Marieke L. de Kam, Lisa Pagan, Manon A.A. Jansen, Matthijs Moerland, Jacobus J. Bosch   +11 more
wiley   +1 more source

Prediction of Acute Liver Injury Trajectory in Patients Following Acetaminophen Overdose: A Multibiomarker Machine Learning Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries, Alastair M. Kilpatrick, Kathleen M. Scullion, Rhona Aird, Lorraine Bruce, Maria Elena Candela, Tak Yung Man, Stuart J. Forbes, James W. Dear   +8 more
wiley   +1 more source

Verbascum thapsus L. ethanol fraction mitigates CCl4-induced hepatic damage via inhibition of TNFα-NF-κB signaling and oxidative stress in rats

Asian Pacific Journal of Tropical Biomedicine
Objective: To evaluate the hepatoprotective effects of the ethanol fraction of Verbascum thapsus L. (EFVT) against CCl4-induced liver injury and elucidate its underlying mechanisms. Methods: The assessment of antioxidant properties and cell viability was
Amina Ishfaq, Hafiz Muhammad Zubair, Farah Abid, Naeem Ur Rehman, Umair Ikram Dar, Shahid Muhammad Iqbal, Ali Sharif, Muhammad Saad Majeed, Muhammad Akhlaq, Samiullah Khan   +9 more
doaj   +1 more source