Results 181 to 190 of about 63,484 (304)

Deciphering the interplay between SGLT2 inhibition, CCL4, and angina pectoris: A Mendelian randomization study. [PDF]

Medicine (Baltimore)
Zhang Y, Zhao Y, Dong Z, Gao Y, Wan D.
europepmc   +1 more source

Recombinant ADAMTS13 Ameliorates Liver Injury and Improves Hepatic Microcirculation in a Murine Acute‐on‐Chronic Liver Failure Model

Hepatology Research, EarlyView.
ABSTRACT Aim The therapeutic significance of recombinant a disintegrin‐like and metalloprotease with thrombospondin type 1 motif 13 (rADAMTS13) in acute‐on‐chronic liver failure (ACLF) remains unclear. We aimed to investigate the therapeutic effects of rADAMTS13 in a murine model of ACLF‐like liver injury.
Jun‐ichi Hanatani, Norihisa Nishimura, Kosuke Kaji, Masayoshi Takami, Hiroyuki Masuda, Hiroaki Takaya, Koh Kitagawa, Shinya Sato, Tadashi Namisaki, Hitoshi Yoshiji   +9 more
wiley   +1 more source

Effect of Short-Chain Fatty Acids In Vivo on the Treatment of CCL₄-Induced Hepatic Fibrosis. [PDF]

Biomedicines
Rodrigues KF, Vivan Tonial G, Scherer Bastos M, Mezzomo Pavanato G, Luft C, Rosa Garcia MC, Dal Moro Maito FL, Campos MM, Rodrigues de Oliveira J.   +8 more
europepmc   +1 more source

CD68 and F4/80 Markers Demonstrate Inflammatory Synergism Between Apical Periodontitis and Liver Fibrosis in Wistar Rats

International Endodontic Journal, EarlyView.
ABSTRACT Aim To evaluate CD68 and F4/80 glycoproteins in the worsening of apical periodontitis (AP) and liver fibrosis (LF) in Wistar rats. Methodology Thirty‐two Wistar rats were distributed in the following groups (n = 8): C—control; AP—apical periodontitis; LF—liver fibrosis; APLF—AP and LF.
L. V. Barroti, C. Cantiga‐Silva, M. P. Justo, P. H. C. Oliveira, F. D. Faria, J. Goto, E. Ervolino, G. Sivieri‐Araújo, T. N. Pinheiro, L. T. A. Cintra   +9 more
wiley   +1 more source

Targeting senescent cells with dipeptidyl peptidase 4-CAR-NK cells alleviates liver fibrosis and reverses metabolic dysfunction. [PDF]

Acta Pharm Sin B
Hua R, Xu K, Peng H, Liu K, Long N, Zeng C, Wang Y, Guo Y, Wang Z.   +8 more
europepmc   +1 more source

Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy

Immunology &Cell Biology, EarlyView.
IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley   +1 more source

Estrogen receptor β activation attenuates portal hypertension and restores mesenteric vascular reactivity in cirrhotic rats <i>via</i> β-arrestin-2/RhoA/ROCK pathway modulation. [PDF]

Clin Exp Hepatol
Sun LC, Ji LH, Zhang B, Wu ZY.
europepmc   +1 more source

Periodontitis and metabolic dysfunction‐associated steatotic liver disease

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis is a chronic inflammatory disease with systemic effects that extend beyond the oral cavity and contribute to systemic immune and metabolic dysregulation. Chronic liver diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and its progressive phenotypes, have emerged as major global ...
Rafael Scaf de Molon, Erica Dorigatti de Avila, Davi da Silva Barbirato, Mariana Fampa Fogacci, Jamil Awad Shibli, Anton Sculean, Alpdogan Kantarci   +6 more
wiley   +1 more source

Comparative Metabolite Profiling of <i>Betula pendula</i> Roth and <i>Betula pubescens</i> Ehrh. Leaf Extracts Reveals Antioxidant and Hepatoprotective Potential. [PDF]

Molecules
Dezső Bab TH, Ielciu I, Hașaș AD, Sevastre B, Olah NK, Pall E, Marica R, Sevastre-Berghian AC, Benedec D, Oniga I, Păltinean R, Hanganu D.   +11 more
europepmc   +1 more source

Cytomegalovirus–Cell‐Mediated Immunity Assays for the Prevention and Management of Cytomegalovirus in Transplant Recipients and Patients Receiving Cellular Therapies

Transplant Infectious Disease, EarlyView.
This review summarizes the emerging role of CMV‐specific cell‐mediated immunity assays in CMV risk prediction and individualized prevention strategies across SOT, HCT, and CAR‐T settings. ABSTRACT CMV cell–mediated immunity (CMV–CMI) testing has emerged as a promising tool to refine CMV risk stratification and inform prevention strategies in transplant
Elisa Ruiz‐Arabi, Madeleine R. Heldman, Laurie D. Snyder, Oriol Manuel, Eleftheria Kampouri   +4 more
wiley   +1 more source