Results 161 to 170 of about 95,656 (302)

Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema

Allergy, EarlyView.
This study performed an unbiased molecular profiling of CHE patients across diverse etiologies to identify shared pathogenic drivers and evaluate the impact of IL‐4Rα blockade via dupilumab over 16 weeks. CHE shows a mixed immune signature involving type 1, 2, and 3 pathways with features of atopic dermatitis and psoriasis.
Perrine Gery, Rüçhan Ekren, Emilie Bérard, Aurélie Du‐Thanh, Hugo Rimet, Fatma Jendoubi, Vanina Lenief, Nadia Raison‐Peyron, Amel Bouznad, Maria P. Konstantinou, Jonathan Rioual, Lilian Basso, Juliette Mouiren, Manon Boussier, Brigitte Milpied, Cristina Bulai Livideanu, Louise Jaulent, Florence Hacard, Marine A. Lefevre, Audrey Nosbaum, Julien Seneschal, Marc Vocanson, Carle Paul, Nicolas Gaudenzio, Marie Tauber, on behalf of the French Atopic Dermatitis Network from de GREAT Research group   +25 more
wiley   +1 more source

Resolvin D1 alleviates liver inflammation and fibrosis through SIRT1-mediated NF-κB and TGF-β1/Smads pathways. [PDF]

J Inflamm (Lond)
Li J, Zhao L, Xi Y, Deng X.
europepmc   +1 more source

IL‐33 Drives Inflammatory Changes and Extracellular Trap Formation in Eosinophils Involving Oxidised LDL and Complement Pathways

Allergy, EarlyView.
IL‐33 induces inflammatory gene signatures in eosinophils, characterised by the upregulation of cell surface markers, inflammatory mediators and regulatory factors, all of which were also observed in nasal polyp‐derived eosinophils. Ox‐LDL and complement fragments (C3a and C5a) promote eosinophil adhesion and survival.
Emiko Matsuyama, Jun Miyata, Takao Mochimaru, Ryuta Onozato, Yo Otsu, Hisashi Sasaki, Keeya Sunata, Shinichi Okuzumi, Katsunori Masaki, Hiroki Kabata, Keinosuke Hizuka, Yoshinori Hasegawa, Ryo Konno, Yusuke Kawashima, Makoto Arita, Shigeharu Ueki, Koichi Fukunaga   +16 more
wiley   +1 more source

Physcion-8-O-β-D-monoglucoside protects hepatocytes from TNF-α-mediated apoptosis by suppressing the PI3K/AKT/NF-κB signaling pathway. [PDF]

Sci Rep
Hu R, Chen Z, Chen T, Chen Z, Luo W, Xu W, Huang M, Nan L, Jia R, Zhang Y, Chen Y.   +10 more
europepmc   +1 more source

The Role of Inflammation in Infant Colic—A Systematic Review and Meta‐Analysis

Acta Paediatrica, EarlyView.
ABSTRACT Aim Despite being a self‐limiting condition, infant colic is associated with negative consequences for caregivers and infants. Gut inflammation is hypothesised as a contributing factor. We collected and meta‐analysed the most recent evidence on the association between infant colic and gut inflammation.
Dan Boëtius Andersen, Julius Fog, Marie V. Vestergaard, Ida Scheel Rasmussen, Philip Wilson, Gritt Overbeck, Louise Bidstrup Jørgensen, Jakob Kragstrup, Betina Hebbelstrup Jensen   +8 more
wiley   +1 more source

<i>miR-122</i> Deficiency in Mice Enhances Regeneration in Healthy Liver but Drives Pathological Repair and Functional Decline in Fibrotic Liver. [PDF]

Int J Mol Sci
Ribera J, Cardona-Simó A, Portolés I, Samper E, Boix L, Fabregat-Bolufer AB, Fernández-Galán E, Rodríguez-Garcia M, Azkargorta M, Elortza F, Celton-Morizur S, Desdouets C, Melgar-Lesmes P, Jiménez W, Casals G, Morales-Ruiz M.   +15 more
europepmc   +1 more source

Neurokinin‐1 receptor activation protects against cardiac fibrosis, inflammation and diastolic dysfunction in type 2 diabetic mice

British Journal of Pharmacology, EarlyView.
Background and Purpose The pathogenesis of type 2 diabetes mellitus (T2DM)‐induced cardiomyopathy involves cardiac fibrosis that leads to diastolic dysfunction. We established that replacement of lost substance P (SP) that occurs in T2DM reduces cardiac fibrosis and decreases inflammation in T2DM mice and non‐human primates.
Alexander Widiapradja, Heather Connery, Brody J. Helmick, Kallie J. Schafner, Vamsi Manchikalapudi, Hannah Horvath, Sophia Gugino, Tamas Kriska, Anja Herrnreiter, Evan DeVallance, William B. Campbell, Scott P. Levick   +11 more
wiley   +1 more source

Continuing industrial emissions are delaying the recovery of the stratospheric ozone layer. [PDF]

Nat Commun
Reimann S, Western LM, Lickley MJ, Sherry D, Daniel JS, Kuijpers LJM, Montzka SA, Rigby M, Velders GJM, Vollmer MK, Emmenegger L, Liang Q, Park S, Solomon S.   +13 more
europepmc   +1 more source

Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue [PDF]

, 2016
et al,, Meganathan, Kesavan
core   +1 more source

Macrophage‐Specific Loss of Stearoyl‐CoA Desaturase 1 Promotes Colon Cancer by Enhancing M2 TAM Polarization

Cancer Science, EarlyView.
Macrophage‐specific Scd1 deletion accelerates colon cancer progression by suppressing the Hippo‐YAP pathway, which drives immunosuppressive M2 polarization and induces CD8+ T cell exhaustion. Pharmacological YAP activation with TT‐10 effectively reverses this microenvironment, highlighting a promising target for immunotherapy. ABSTRACT In colon cancer (
Qing You, Jiaqi Du, Ziran Wei, Yandong Liu, Weijun Wang, Wenchao Gao   +5 more
wiley   +1 more source