Results 151 to 160 of about 95,656 (302)

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source

Forsythiaside A Alleviates Kidney Injury and Intestinal Epithelium Dysfunction in IgA Nephropathy by Inhibiting TLR4/NF‐κB Signaling

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT IgA nephropathy (IgAN), the most common form of glomerulonephritis, is a major and growing public health issue. It results from intestinal barrier dysfunction that leads to mesangial deposition of pathogenic galactose‐deficient IgA1 (Gd‐IgA1) and renal inflammation.
Meng‐Si Li, Kai Liu
wiley   +1 more source

Macrophages expressing macrophage receptor with collagen structure attenuate liver fibrosis through a tissue restoration phenotype. [PDF]

JCI Insight
Jerez S, Cooper SA, Yaqoob U, Kalaiger MF, Anwar AA, Wong M, Arif B, Doskey LC, Hernandez-Tejero M, Sherman WA, De Boeck R, Li Y, Hilscher MB, Kostallari E, Jalan-Sakrikar N, Cao S, Shah VH.   +16 more
europepmc   +1 more source

Retatrutide Shows Multiple Metabolic Benefits in Diet‐Induced Obese MASH Mouse and Hamster Models

Obesity, EarlyView.
ABSTRACT Objective/Methods Our aim was to evaluate the efficacy of the triple glucagon, GIP, and GLP‐1 receptor agonist retatrutide in diet‐induced obese MASH mouse and hamster models, two preclinical models that we routinely use for assessing new therapies targeting obesity.
François Briand, Camille Le Cudennec, Estelle Grasset, Natalia Breyner, Claire Bigot, Pierre Dillard, Thierry Sulpice   +6 more
wiley   +1 more source

Quercetin alleviates CCl₄-induced liver fibrosis via regulating gut microbiota and the AGE-RAGE/PI3K/Akt signaling axis. [PDF]

Biochem Biophys Rep
Tang Y, Jiang YH, Wu CY, Wang GT, Li ML.
europepmc   +1 more source

Reduction‐Controlled Tunable Synthesis of Covellite (CuS) Nanoparticles from Water‐Soluble Single‐Source Precursors

Small, EarlyView.
Amino acid‐derived Cu(II)‐dithiocarbamates were synthesized as water‐soluble single‐source precursors for low‐temperature hydrothermal decomposition toward covellite (CuS) nanoparticles. Their decomposition followed a reduction‐mediated pathway via Cu(I)‐dithiocarbamate intermediates, with the reduction step being rate‐limiting and readily tunable ...
Xiang Xu, Siqiao Huang, Desmond A. Koomson, Tannith‐Jade Cole, Yuanyang Xie, Jagodish C. Sarker, David Pugh, Cécile A. Dreiss, Graeme Hogarth   +8 more
wiley   +1 more source

Protective Effects of <i>Luffa cylindrica</i> Leaf Infusion Against Cisplatin and CCl₄-Induced Hepatorenal Toxicity in Rats: Biochemical, Histopathological, and Molecular Docking Analysis. [PDF]

J Toxicol
Hlel TB, Feriani A, Khelifi N, Abbes Z, Smaali I.   +4 more
europepmc   +1 more source

Immune escape mechanisms revealed by multifunctional nanoprobes targeting PD‐L1 in hepatic cancer progression

VIEW, EarlyView.
The ICGB@Apt nanoprobes are designed to specifically recognize immune checkpoint molecules such as PD‐L1, thereby enabling precise monitoring of the progression from liver cirrhosis to HC. By binding to PD‐L1 on tumor cells, ICGB@Apt visualizes immune escape events and tumor metastasis while simultaneously reflecting the dynamic interaction between ...
Yiteng Meng, Liwen Jing, Yeda Chen, Shenggang Zhan, Feng Xiong, Wenbiao Chen   +5 more
wiley   +1 more source

Evaluation of a 3,5-diethoxycarbonyl-1,4-dihydrocollidine diet-induced mouse model in a comparative experimental study of portal hypertension. [PDF]

World J Gastroenterol
Zhao JB, Wu ZH, Lin JY, Luo GQ, Zhang CH, Wu GB, Fan Q, Qi XL, Huo HZ, Yu JW, Li HJ, Zheng L, Luo M.   +12 more
europepmc   +1 more source

Type 2 lymphocytes restrict type 3 lymphocytes during liver fibrosis and colocalize in fibroblast niches. [PDF]

Sci Adv
Sbierski-Kind J, Cautivo KM, Nilsson J, Wagner JC, Dahlgren MW, Crystal NE, McClave M, Mroz NM, Ganslmeier M, Lizama CO, Gan AL, Matatia PR, Taruselli MT, Chang AA, Caryotakis S, O'Leary CE, Kotas M, Lee JH, Gu T, Seo H, Kim HJ, Mattis AN, Peng T, Locksley RM, Molofsky AB.   +24 more
europepmc   +1 more source