Results 171 to 180 of about 63,484 (304)

Macrophage-Centered Integration of Single-Cell and Bulk Transcriptomic Data Identifies CCL3, CCL4, and JUNB as Inflammatory Regulatory Signatures in Ulcerative Colitis. [PDF]

Genes (Basel)
Meng H, Chen Y, Chai Y, Yu S, Ma P, Lei R, Zhou S, Lv W.   +7 more
europepmc   +1 more source

scRNA‐Seq in Gastric Cancer Reveals Macrophage‐Derived C1q as a Diagnostic Marker

Cancer Science, EarlyView.
Single‐cell sequencing of GC analyzed the tumor microenvironment and discovered the C1QA+ TAMs subpopulation with immunosuppressive function. The role of C1q in the prognosis and diagnosis of GC was demonstrated through plasma and tumor tissue from the GC cohort.
Saisai Gong, Yupeng Zhao, Sheng Yang, Tong Liu, Chengyun Li, Yun Zhou, Geyu Liang   +6 more
wiley   +1 more source

<i>SAE1</i> knockdown attenuates hepatic fibrosis by promoting ubiquitination and proteasomal degradation of TGF-β receptors. [PDF]

BMJ Open Gastroenterol
Liu T, Wang M, Zheng G, Wu Y, Shen J, Dong X, Sun Q, Zhang Y, Tian W.   +8 more
europepmc   +1 more source

SLAMF6 Enhances the Efficacy of Anti‐PD‐L1 Immunotherapy in CRC Through the STAT1/CXCL10 Signaling Axis

Cancer Science, EarlyView.
SLAMF6 recruits SHP‐2 to activate STAT1, upregulates CXCL10 and PD‐L1, promotes CD8+T cell infiltration, and enhances the efficacy of anti‐PD‐L1 therapy. ABSTRACT As a T‐cell receptor co‐stimulatory protein, signaling lymphocyte activation molecule family 6 (SLAMF6) is a member of the immune cell activating receptor family and is expressed on T cells ...
Yu Wu, Xinhui Lv, Shunhao Zhang, Yafang Chen, Sicong Liu, Feiyang Song, Chunmei Zhao, Guihua Wang, Xudong Wang   +8 more
wiley   +1 more source

Protective Effects of the Ethanolic Leaf Extract of <i>Ocimum sanctum</i> L. on Collagen-Induced Human Platelet Aggregation and CCl₄-Induced Hepatotoxicity in Rats: Molecular Docking Analysis of Platelet Activation Signaling Targets. [PDF]

Molecules
Maaz M, Balupillai A, Periyakali S, Padhan J, Kalavathy Murugan K, Sheu JR, Thanasekaran J.   +6 more
europepmc   +1 more source

Sensor‐Detected Hypoglycaemia Is Associated With Inflammatory Protein and Immune Cell Alterations in People With Diabetes: Findings From the Hypo‐METRICS Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Experimental hypoglycaemia induces a persistent inflammatory response. We investigated whether real‐life sensor‐detected hypoglycaemia (SDH) is associated with immune parameters in people with Type 1 and Type 2 diabetes and explored potential differences between the groups.
Mandala Ajie, Namam Ali, Marijn S. Hendriksz, Patrick Divilly, Marloes J. Rietveld, Evertine J. Abbink, Pratik Choudhary, Julie Maria Bøggild Brøsen, Ulrik Pedersen‐Bjergaard, Rory J. McCrimmon, Mark Evans, Julia K. Mader, Bastiaan E. de Galan, Rinke Stienstra, Cees J. Tack, on behalf of the Hypo‐RESOLVE Consortium   +15 more
wiley   +1 more source

Retraction Note: Melatonin loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles reduce inflammation, inhibit apoptosis and protect rat's liver from the hazardous effects of CCL4. [PDF]

Sci Rep
Farid A, Michael V, Safwat G.
europepmc   +1 more source

Mechanical stiffness orchestrates distinct regulation of MRTFs and YAP/TAZ transcriptional cofactors in hepatocytes

The FEBS Journal, EarlyView.
MRTFs and YAP/TAZ proteins, or mechanosensitive transcriptional cofactors (MRTcoF), regulate common genes associated with cellular contractility and immune cell infiltration. Their differential regulation in response to stiffness is linked to changes in hepatocyte's aspect ratio. MRTFB does not undergo nuclear translocation under these conditions. This
Brenda Selene Torres‐Ortiz, Daniel Pérez‐Calixto, Jorge Carretero‐Ortega, Aida Gabriela Guzman‐López, Diana Cristina Pinto‐Dueñas, Mariana Hernández‐Juárez, Alejandra Jiménez‐Escobar, Adriana Rodríguez‐Hernández, Beatriz Díaz‐Bello, Nathalia Serna‐Márquez, Miguel Ángel Peña‐Rico, Laura Gómez‐Romero, Francisco Gabriel Vázquez‐Cuevas, Genaro Vázquez‐Victorio   +13 more
wiley   +1 more source

Gut Commensal Bacteria Ameliorate Liver Fibrosis by Inhibiting Macrophage M1 Polarization Through Secondary Bile Acids in a Murine Liver Fibrosis Model. [PDF]

Microorganisms
Xiang H, Xiang H, Liu Z, Chen H, Luo Z, Guo S, Zhang J.   +6 more
europepmc   +1 more source

Structural insights into tyrosine sulfation of CCR5 by human tyrosylprotein sulfotransferase‐1

The FEBS Journal, EarlyView.
Structural analysis of human tyrosylprotein sulfotransferase‐1 (hTPST1) bound to a CCR5 N‐terminal peptide reveals how hTPST1 recognizes the Tyr3 sulfation site. Structure‐guided models of additional CCR5 sulfation states and full‐length assemblies provide a framework for understanding CCR5 tyrosine sulfation, a post‐translational modification relevant
Shinnosuke Tanaka, Hirai Asano, Kota Toyoda, Toshiaki Nishiyori, Hidetaka Kojo, Kazuto Kiyomatsu, Katsuhisa Kurogi, Yoichi Sakakibara, Etsuko Nishimoto, Takamasa Teramoto, Yoshimitsu Kakuta   +10 more
wiley   +1 more source