Results 61 to 70 of about 63,484 (304)

Pomegranate juice treatment reverses carbon tetrachloride (CCl4)-induced increased acetylcholinesterase activity and cell death via suppression of oxidative stress in rats

Background Environmental pollution, including exposure to carbon tetrachloride (CCl4), poses serious health risks, particularly through oxidative stress, which may lead to neurodegenerative damage. Antioxidants, especially those found in natural products,
Ömer Faruk Kalkan, Yoloğlu, Ertan, Cihan Çitil, Ahmet Özkaya, Ertan Yoloğlu, Akın Kirbaş, Özkaya, Ahmet, Bülbül, Şeyda Çağri, Miraç Uçkun, KALKAN, ÖMER FARUK, Ahmet Türk, Özay, Yusuf, Çitil, Cihan, ŞAHİN, ZAFER, KIRBAŞ, Akın, Yusuf Özay, Şeyda Çağri Bülbül, Uçkun, Miraç, Zafer Şahin, Türk, Ahmet   +19 more
core   +1 more source

CO6-MMP serum levels in CCl4-treated rats.

, 2013
CCl4 rat liver fibrosis model: (A) Serum CO6-MMP was assessed in control rats at termination (controls) as well as in CCl4-treated rats at termination (CCl4) at weeks 8, 12, 16, 20. Results shown are mean ± standard error of the mean (SEM); (B) Serum CO6-
Morten Asser Karsdal (317796), Ben Vainer (344474), Sanne Skovgård Veidal (344464), Efstathios Vassiliadis (344465), Arkadiusz Nawrocki (344466), Quoc Hai Trieu Nguyen (344468), Per Hägglund (344470), Qinlong Zheng (344473), Diana Julie Leeming (344475), Martin Røssel Larsen (344467), Yunyun Luo (344472)   +10 more
core   +1 more source

A Glucose Metabolism‐Modulatory Nanobiohybrid Vaccine Platform Promotes Anti‐Tumor Immunity by Orchestrating Autophagy‐Dependent Cross‐Presentation and H2S‐Enhanced NLRP3 Inflammasome Signaling

Advanced Science, EarlyView.
A nanobiohybrid vaccine was designed by constructing a hydrogen‐bonded organic framework coencapsulated with glucose oxidase (GOx) and tumor antigens. This nanobiohybrid vaccine executed a GOx‐catalyzed enzyme reaction that disrupted glucose metabolism and induced redox imbalance in dendritic cells, leading to autophagy‐dependent antigen cross ...
Weidong Wang, Yimin Gong, Jianing Li, Tianze Wu, Mingli Deng, Yannan Yang   +5 more
wiley   +1 more source

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Chronic HBV Infection Disrupts CCL5‐Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV‐Specific T Cells

Advanced Science, EarlyView.
ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.
Ailu Yang, Yucan Wang, Yating Yu, Jing Wu, Cuiping Bao, Zixuan Wang, Qiuju Han, Zhigang Tian, Jian Zhang, Huajun Zhao   +9 more
wiley   +1 more source

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Lagerstroemia indica methanolic extract alleviates CCl4-induced liver toxicity via modulation of Nrf2 signaling pathway in rats

Asian Pacific Journal of Tropical Biomedicine
Objective: To assess the hepatoprotective effects of methanolic extract of Lagerstroemia indica leaves on carbon tetrachloride (CCl4)-induced liver damage in rats. Methods: Fifty male Sprague Dawley rats were divided into five groups: the normal control,
Jaweria Nisar, Muhammad Sarwar, Syed Ali Raza Shah, Shagufta Yasmin, Hamza Farooq, Hira Moin, Imtiaz Mustafa   +6 more
doaj   +1 more source

Experimental determination of CCl4 hydrate phase equlibria up to high pressures

, 2015
A number of hydrate phase boundaries of the binary system of tetrachloromethane (CCl4) + water were measured experimentally at several temperatures and from low pressures up to 89.25 MPa. These hydrate phase boundaries included hydrate–ice–vapor, hydrate–
Geert H. Lameris, Peters, C.J., Peters, CJ Cor, Shariati - Sarabi, A Alireza, Lameris, G.H., Lameris, GH, Shariati - Sarabi, A., Alireza Shariati, Cor J. Peters   +8 more
core   +1 more source

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

CD11b+CD43hiLy6Clo splenocyte‐derived macrophages exacerbate liver fibrosis via spleen–liver axis

Hepatology, EarlyView., 2022
A population of splenic monocytes migrate into the liver and shift to macrophages, which account for the exacerbation of liver fibrosis. Abstract Background and Aims Monocyte‐derived macrophages (MoMFs), a dominant population of hepatic macrophages under inflammation, play a crucial role in liver fibrosis progression.
Shaoying Zhang, Dan Wan, Mengchen Zhu, Guihu Wang, Xurui Zhang, Na Huang, Jian Zhang, Chongyu Zhang, Qi Shang, Chen Zhang, Xi Liu, Fanfan Liang, Chunyan Zhang, Guangyao Kong, Jing Geng, Libo Yao, Shemin Lu, Yongyan Chen, Zongfang Li   +18 more
wiley   +1 more source