Results 61 to 70 of about 95,656 (302)

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

open access: yesHepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai   +29 more
wiley   +1 more source

Hepatoprotective Effects of Fumaria parviflora L. on CCl4–induced hepatotoxicity

open access: yesJournal of Medicinal Plants, 2006
Background: Liver, the largest internal organ in the body, plays a central role in many essential physiologic processes and has numerous functions. Nevertheless, its disorders are many fold.
A Jamshidzadeh, H Nikmahad
doaj  

The Effect of Leunca Fruit (Solanum nigrum Linn) Infusion in Inhibiting the Increase of Serum Glutamate Pyruvate Transaminase Level in CCL4 Induced Hepatitis Wistar Rats

open access: yesAlthea Medical Journal, 2019
Background: Hepatitis may cause liver cell damage due to the oxidation processes and can be inhibited by antioxidant components. Antioxidant acts as hepatoprotector by slowing down the oxidation process.
Kuswinarti Kuswinarti   +2 more
doaj   +1 more source

Chemokines in depression in health and in inflammatory illness: a systematic review and meta-analysis [PDF]

open access: yes, 2018
Inflammatory illness is associated with depression. Preclinical work has shown that chemokines are linked with peripheral–central crosstalk and may be important in mediating depressive behaviours.
Cavanagh, J.   +5 more
core   +1 more source

Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration

open access: yesAdvanced Science, EarlyView.
Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman   +5 more
wiley   +1 more source

Protective effect of aqueous extract of Alhagi maurorum in spermatogenesis and antioxidant status of adult rats exposed to carbon tetrachloride [PDF]

open access: yesIraqi Journal of Veterinary Sciences, 2019
This Study aimed to investigate the efficiency of aqueous extraction of Alhagi maurorum leaves against oxidative stress induced by Carbon tetrachloride (CCl4) on spermatogenesis and the level of glutathione, superoxide dismutase, malondialdehyde in adult
Measer Abdullah Ahmed
doaj   +1 more source

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

open access: yesAdvanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang   +17 more
wiley   +1 more source

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

open access: yesHepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro   +17 more
wiley   +1 more source

Luminescent Donor‐Acceptor Radical With Propeller Chirality: Bright and Photostable Red Circularly Polarized Luminescence and Whispering Gallery Mode Resonance

open access: yesAngewandte Chemie, EarlyView.
A series of donor‐attached brominated chiral luminescent radicals (CzTTBrM, 2CzTTBrM, and 3CzTTBrM) was synthesized, showing red to near‐infrared (NIR) circularly polarized luminescence (CPL) with exceptionally high PLQY of up to 76% and markedly enhanced CPL brightness (BCPL). Doping into polystyrene microspheres further yields whispering gallery mode
Kazuhiro Nakamura   +14 more
wiley   +2 more sources

Recycling of solvent used in a solvent extraction of petroleum hydrocarbons contaminated soil. [PDF]

open access: yes, 2011
The application of water washing technology for recycling an organic composite solvent consisting of hexane and pentane (4:1; TU-A solvent) was investigated for extracting total petroleum hydrocarbons (TPH) from contaminated soil. The effects of water
Coulon, Frederic   +5 more
core   +1 more source

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