Results 81 to 90 of about 63,484 (304)

NSUN2‐Mediated m5C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA

Advanced Science, EarlyView.
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu, Xinkui Liu, Xiaoyan Yu, Qiaoqiao Han, Feifei Shi, Weiwei Song, Lu Liu, Chu Chu, Chenyang Shen, Zhen Zhang, Xia Li   +10 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Breakthrough Design of Highly Potent Antivirals Against Wild‐Type HIV‐1 and Lenacapavir‐Resistant M66I Variant

Angewandte Chemie, EarlyView.
Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey, D. M. Nirosh Udayanga, Huanchun Zhang, Roshan Katekar, Wei Xie, Shreya M. Ravichandran, Xinyong Cai, Zachary C. Lorson, William M. McFadden, Won Hee Ryu, Jiashu Xie, Karen A. Kirby, Stefan G. Sarafianos, Zhengqiang Wang   +13 more
wiley   +2 more sources

Mangiferin Ameliorates CCl4-Triggered Acute Liver Injury by Inhibiting Inflammatory Response and Oxidative Stress: Involving the Nrf2-ARE Pathway [PDF]

Caixing Shi,1 Yueyao Li,2 Zhidong You,3 Yiran Tian,4 Xiaoyu Zhu,4 Hao Xu,4 Menghan Yang,4 Yutong Zhang,4 Rui Dong,4 Huirong Quan,4 Yongyi Shang,4 Xiaojin Li1 1School of Basic Medicine, Jining Medical University, Jining, 272067, People’s Republic of China;
Li X, Li Y, You Z, Shi C, Zhang Y, Tian Y, Yang M, Shang Y, Zhu X, Xu H, Quan H, Dong R   +11 more
core  

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

Effect of Mesenchymal Stem Cells’ Conditioned Medium on the Expression of CCL3 and CCL4 Chemokines in the Spinal Cord of Rats with Neuropathic Pain [PDF]

Journal of Mazandaran University of Medical Sciences, 2023
Background and purpose: Inflammation plays an important role in the development of neuropathic pain (NP). Considering the anti-inflammatory effects of mesenchymal stem cells (MSCs) and their conditioned medium (CM), we aimed to investigate the effect of ...
Mohammad-Shafi Mojadadi, Kimia Shahrazad, Samad Nazemi, Saeideh Sadat Shobeiri   +3 more
doaj  

Cálculo das propriedades dinâmicas dos sistemas moleculares H2O-He, H2O-Ne, H2O-Ar, H2O-Kr, H2O-Xe, CCl4-He, CCl4-Ar, CCl4-Ne, CCl4-O2, CCl4-D2O e CCl4-ND3

, 2014
Dissertação (mestrado)—Universidade de Brasília, Pós-Graduação em Física, 2014.O objetivo principal deste trabalho foi o c´alculo das energias e constantes espectroscópicas rovibracionais de dois conjuntos de sistemas moleculares: água com os gases ...
Oliveira, Rhuiago Mendes de
core  

CCL4 secretion by PMNs.

, 2014
PMNs were cultured in control medium or in conditioned medium of unstimulated or LPS-stimulated MSCs for 24 hours. CCL4 secreted by PMNs was measured by ELISA. Data are presented as median of 3 independent experiments. ANOVA test was used for statistical
Kirsten Bruderek (631694), Stefanie B. Flohé (631698), Friedrich Bootz (395015), Bernd Giebel (255529), Sven Brandau (70736), Mark Jakob (631693), Katharina Mauel (631696), Stephan Lang (164228), Stefan Radtke (631695), Marcus Jäger (631697)   +9 more
core   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Antioxidant and Hepatoprotective Properties of Vicia cracca Against Carbon Tetrachloride Induced Oxidative Stress in Mice

Journal of Mazandaran University of Medical Sciences, 2018
Background and purpose: Vicia cracca (Papilionaceae) has 45 species in Iran. Vicia spp. are known medicinal plants. Some species in this family are well known with distinctive antioxidant activity.
Mohammad Shokrzadeh, Farshid Rahimi, Ali Ziar, Mohammad Ali Ebrahimzadeh   +3 more
doaj