Results 231 to 240 of about 76,869 (253)
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Entzündungssignal RANTES / CCL5 aus dem Kieferknochen
Zeitschrift für Komplementärmedizin, 2018Summary Hintergrund: Diese Studie behandelt die Frage, ob allgemeine und weit verbreitete zahnärztliche Eingriffe, wie Zahnextraktionen und operative Entfernung von Weisheitszähnen, zu chronischer Kieferknochenentzündung führen. Eine mangelhafte Wundheilung im Kieferknochen kann über Entzündungsmediatoren eine versteckte Ursache chronischer ...
Volker von Baehr, Johann Lechner
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CCL5 as an adjuvant for cancer immunotherapy
Expert Opinion on Biological Therapy, 2010To date cancer immunotherapy has only achieved limited clinical efficacy, thus more efficient immunotherapeutic approaches need to be explored. The CC chemokine CCL5 plays a role in chemoattraction and activation of immune cells implying its potential clinical application as an adjuvant for boosting anti-tumor immunity, although an effect on ...
Natalia, Lapteva, Xue F, Huang
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Angiogenic properties of the chemokine RANTES/CCL5
Biochemical Society Transactions, 2011Atherosclerosis is an inflammatory disease that is one of the leading causes of death in developed countries. This disease is defined by the formation of an atherosclerotic plaque, which is responsible for artery obstruction and affects the heart by causing myocardial infarction.
Suffee, Nadine +5 more
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The CCL5/CCR5 axis in ulcerative colitis
Cellular ImmunologyUlcerative colitis (UC) is a chronic nonspecific inflammatory bowel disease characterized mainly by inflammatory changes in the intestinal mucosa. While the specific etiology of UC remains unclear, it is generally believed that it is related to many factors, among which the imbalance in the expression of molecules involved in pro-inflammatory and anti ...
Fan Fan Qu +8 more
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Inhibition of metastasis by inhibition of tumor-derived CCL5
Breast Cancer Research and Treatment, 2005To determine whether tumor-derived CCL5 contributes to the metastatic potential of murine mammary carcinoma, we used the 4T1 tumor which spontaneously metastasizes and constitutively produces CCL5. Mice bearing 4T1 that expressed less CCL5 had significantly fewer lung and liver metastasis.
Kerry A, Stormes +4 more
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Human Immunology, 2017
Genetic variations in chemokine genes influence the chemoattractive properties of T cells which may be associated with outcome of infections. In present study, we have investigated the regulatory role played by In1.1T/C (rs2280789) polymorphism of CCL5 and -135G/A (rs56061981) polymorphism of CXCL10 gene on intracellular CCL5 and CXCL10 expression in T
Singh, Brijendra +2 more
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Genetic variations in chemokine genes influence the chemoattractive properties of T cells which may be associated with outcome of infections. In present study, we have investigated the regulatory role played by In1.1T/C (rs2280789) polymorphism of CCL5 and -135G/A (rs56061981) polymorphism of CXCL10 gene on intracellular CCL5 and CXCL10 expression in T
Singh, Brijendra +2 more
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A dual role for tumor-derived chemokine RANTES (CCL5)
Immunology Letters, 2003To investigate the role of tumor-derived CCL5 (regulated upon activation, normal T cell expressed and secreted, RANTES) in tumor immunity we compared the T cell response to tumors derived from the 4T1 murine mammary carcinoma cell line that express different levels of CCL5.
Evan P, Adler +3 more
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The potential to target CCL5/CCR5 in breast cancer
Expert Opinion on Therapeutic Targets, 2014Chemokines play a crucial role in breast cancer tumorigenesis and progression. Recently, the chemokine (C-C motif) ligand 5 (CCL5), which can be secreted either by tumor cells or by mesenchymal stromal cells recruited to the tumor, has been identified as a key node in the bidirectional communication between breast cancer and normal cells.In this review,
Marco, Velasco-Velázquez +2 more
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2009
The multifaceted roles of chemokines and of their receptors in physiological and pathological conditions have motivated researchers to analyze their involvement also in malignant diseases. This chapter focuses on CCL5 (RANTES) and its CCR5 receptor in cancer, describing their expression patterns, activities, and roles in several malignancies. Thus far,
Gali Soria, Adit Ben-Baruch
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The multifaceted roles of chemokines and of their receptors in physiological and pathological conditions have motivated researchers to analyze their involvement also in malignant diseases. This chapter focuses on CCL5 (RANTES) and its CCR5 receptor in cancer, describing their expression patterns, activities, and roles in several malignancies. Thus far,
Gali Soria, Adit Ben-Baruch
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The inflammatory chemokines CCL2 and CCL5 in breast cancer
Cancer Letters, 2008A causal role was recently attributed to inflammation in many malignant diseases, including breast cancer. The different inflammatory mediators that are involved in this disease include cells, cytokines and chemokines. Of these, many studies have addressed the involvement and roles of the inflammatory chemokines CCL2 (MCP-1) and CCL5 (RANTES) in breast
Gali, Soria, Adit, Ben-Baruch
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