Results 91 to 100 of about 65,957 (231)

CCR2⁺CD103⁻ intestinal dendritic cells develop from DC-committed precursors and induce interleukin-17 production by T cells [PDF]

, 2014
The identification of intestinal macrophages (m phi s) and dendritic cells (DCs) is a matter of intense debate. Although CD103(+) mononuclear phagocytes (MPs) appear to be genuine DCs, the nature and origins of CD103(-) MPs remain controversial.
Agace, William,, Bain, C C, Guilliams, M, Kotarsky, Knut,, Lambrecht, B N, Luda, Katarzyna,, Lund University., Milling, S Wf, Mowat, Allan,, Persson, Emma,, Scott, C L, Sichien, D, Wright, P B   +12 more
core   +3 more sources

Myocardial infarction primes autoreactive T cells through activation of dendritic cells [PDF]

, 2017
Peripheral tolerance is crucial for avoiding activation of self-reactive T cells to tissue-restricted antigens. Sterile tissue injury can break peripheral tolerance, but it is unclear how autoreactive T cells get activated in response to self. An example
Bouché, Ann, Carmeliet, Peter, De Prijck, Sofie, Gillebert, Thierry, Guilliams, Martin, Lambrecht, Bart, Ludewig, Burkhard, Martens, Liesbet, Nindl, Veronika, Saeys, Yvan, Scott, Charlotte, Sichien, Dorine, Van Der Borght, Katrien, Van Moorleghem, Justine, Vanheerswynghels, Manon   +14 more
core   +6 more sources

Expression of the monocyte chemoattractant protein-1 receptor CCR2 is increased in hypercholesterolemia: differential effects of plasma lipoproteins on monocyte function

Journal of Lipid Research, 1999
Monocytes are recruited from the circulation into the subendothelial space where they differentiate into mature macrophages and internalize modified lipoproteins to become lipid-laden foam cells.
Ki Hoon Han, Ki Ok Han, Simone R. Green, Oswald Quehenberger   +3 more
doaj   +1 more source

Macrophage-derived human resistin is induced in multiple helminth infections and promotes inflammatory monocytes and increased parasite burden. [PDF]

, 2015
Parasitic helminth infections can be associated with lifelong morbidity such as immune-mediated organ failure. A better understanding of the host immune response to helminths could provide new avenues to promote parasite clearance and/or alleviate ...
A Tarkowski, AL Moncayo, AM Gan, B Min, Cathy Steel, CH Kuo, CM Steppan, D Artis, D Voehringer, DD Taub, DR Herbert, DR Herbert, DR Neill, Edward J. Pearce, F Chen, Gang Chen, GD Thomas, Graham Le Gros, H Helmby, HK Park, HS Jung, J Bethony, J Urban, J Wang, JA Jackson, Jessica C. Jang, JF Urban Jr, JI Odegaard, JJ Reece, Josiah I. Chung, JT Pesce, K Migita, KT Cuenco, L Boring, L Le Goff, L Patel, LC Osborne, M Lehrke, M Lehrke, M Qatanani, Mali Camberis, Mark A. Barnes, Meera G. Nair, MG Nair, MG Nair, MG Nair, Mitchell A. Lazar, MM Pirvulescu, MP Reilly, N Silswal, P Loke, PF Weller, Philip J. Cooper, PJ George, PJ Hotez, R Anuradha, RM Anthony, RT Semnani, RZ Yang, S Babu, S Babu, S Babu, S Babu, S Jiang, S Lee, Spencer H. Wang, Thomas B. Nutman, TT MacDonald, W He, Y Benomar, YY Hsieh   +70 more
core   +5 more sources

Blocking spinal CCR2 with AZ889 reversed hyperalgesia in a model of neuropathic pain

Molecular Pain, 2010
Background The CCR2/CCL2 system has been identified as a regulator in the pathogenesis of neuropathy-induced pain. However, CCR2 target validation in analgesia and the mechanism underlying antinociception produced by CCR2 antagonists remains poorly ...
Vaillancourt François, Lembo Paola MC, Lessard Etienne, Jomphe Claudia, Martino Giovanni, Elmes Steven JR, McIntosh Fraser, Paré Michel, Serrano Alexandre, Perkins Martin N, Cao Chang   +10 more
doaj   +1 more source

Cloning and functional characterization of the rabbit C-C chemokine receptor 2

BMC Immunology, 2005
Background CC-family chemokine receptor 2 (CCR2) is implicated in the trafficking of blood-borne monocytes to sites of inflammation and is implicated in the pathogenesis of several inflammatory diseases such as rheumatoid arthritis, multiple sclerosis ...
Hamdouchi Chafiq, Su Eric W, Wang He, Pappas Amy T, Evans Robert J, Yuan Xiu-juan, Lu Deshun, Venkataraman Chandrasekar   +7 more
doaj   +1 more source

Chemokine (C-C Motif) Ligand 2/Chemokine Receptor 2 (CCR2) Axis Blockade to Delay Chondrocyte Hypertrophy as a Therapeutic Strategy for Osteoarthritis

, 2021
Zidong Wang, Bei Wang, Jian Zhang, Zhensong Wu, Liankui Yu, Zhongye Sun   +5 more
openalex   +1 more source

Pro-Inflammatory Chemokines and Cytokines Dominate the Blister Fluid Molecular Signature in Patients with Epidermolysis Bullosa and Affect Leukocyte and Stem Cell Migration. [PDF]

, 2017
Hereditary epidermolysis bullosa (EB) is associated with skin blistering and the development of chronic nonhealing wounds. Although clinical studies have shown that cell-based therapies improve wound healing, the recruitment of therapeutic cells to ...
Alexeev, Vitali, Fortuna, Giulio, Igoucheva, Olga, Mukhtarzada, Lila, Palisson, Francis, Salas-Alanis, Julio Cesar, South, Andrew P., Uitto, Jouni   +7 more
core   +1 more source

MCP-1-CCR2-M2 macrophages axis contributes to diffuse large B-cell lymphoma progression and inhibits antitumor immune response

Scientific Reports
Diffuse large B-cell lymphoma (DLBCL) is an aggressive hematological malignancy with restricted effective therapy choices. Neither the recruitment of monocytes nor the functioning of the physiological mechanisms of macrophage polarization can be achieved
Zhao-Feng Wen, Qi-Tang Huang, Yang-Yang Wang, Feng-Ya Nan, Zhi-Min Zhai, Yan-Li Li   +5 more
doaj   +1 more source

CCR2 Signaling Promotes Brain Infiltration of Inflammatory Monocytes and Contributes to Neuropathology during Cryptococcal Meningoencephalitis

, 2021
Jintao Xu, Anutosh Ganguly, Jessica Zhao, Michel Ivey, Rafael Lopez, John J. Osterholzer, Clifford S. Cho, Michal A. Olszewski   +7 more
openalex   +1 more source