Results 141 to 150 of about 71,715 (302)

Myocardial infarction primes autoreactive T cells through activation of dendritic cells [PDF]

, 2017
Peripheral tolerance is crucial for avoiding activation of self-reactive T cells to tissue-restricted antigens. Sterile tissue injury can break peripheral tolerance, but it is unclear how autoreactive T cells get activated in response to self. An example
Bouché, Ann, Carmeliet, Peter, De Prijck, Sofie, Gillebert, Thierry, Guilliams, Martin, Lambrecht, Bart, Ludewig, Burkhard, Martens, Liesbet, Nindl, Veronika, Saeys, Yvan, Scott, Charlotte, Sichien, Dorine, Van Der Borght, Katrien, Van Moorleghem, Justine, Vanheerswynghels, Manon   +14 more
core   +6 more sources

Fibroblast Plasticity in Inflammation of the Barrier

Barrier Immunity, EarlyView.
Under inflammatory condition, fibroblasts in barrier tissues integrate inflammatory, senescent, and mechanical inputs. These pathways activate central signaling networks to drive fibroblast phenotypic transition, enabling cytokine production, immune cell recruitment, and extracellular matrix remodeling.
Chen Zhang, Hao Wu, Wei Li
wiley   +1 more source

Tubular GM-CSF Promotes Late MCP-1/CCR2-Mediated Fibrosis and Inflammation after Ischemia/Reperfusion Injury.

Journal of the American Society of Nephrology, 2019
BACKGROUND After bilateral kidney ischemia/reperfusion injury (IRI), monocytes infiltrate the kidney and differentiate into proinflammatory macrophages in response to the initial kidney damage, and then transition to a form that promotes kidney repair ...
Leyuan Xu, D. Sharkey, L. Cantley
semanticscholar   +1 more source

Atypical chemokine receptor ACKR2 controls branching morphogenesis in the developing mammary gland [PDF]

, 2016
Macrophages are important regulators of branching morphogenesis during development and postnatally in the mammary gland. Regulation of macrophage dynamics during these processes can therefore have a profound impact on development.
Cairney, Claire J., Graham, Gerard J., Hansell, Christopher A., Hewit, Kay D., Lee, Kit M., Pallas, Kenneth J., Stein, Torsten, Wilson, Gillian J.   +7 more
core   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Blocking spinal CCR2 with AZ889 reversed hyperalgesia in a model of neuropathic pain

Molecular Pain, 2010
Background The CCR2/CCL2 system has been identified as a regulator in the pathogenesis of neuropathy-induced pain. However, CCR2 target validation in analgesia and the mechanism underlying antinociception produced by CCR2 antagonists remains poorly ...
Vaillancourt François, Lembo Paola MC, Lessard Etienne, Jomphe Claudia, Martino Giovanni, Elmes Steven JR, McIntosh Fraser, Paré Michel, Serrano Alexandre, Perkins Martin N, Cao Chang   +10 more
doaj   +1 more source

Dual CCR5/CCR2 targeting: opportunities for the cure of complex disorders

Cellular and Molecular Life Sciences, 2019
The chemokine system mediates acute inflammation by driving leukocyte migration to damaged or infected tissues. However, elevated expression of chemokines and their receptors can contribute to chronic inflammation and malignancy.
L. Fantuzzi, M. Tagliamonte, M. Gauzzi, L. Lopalco   +3 more
semanticscholar   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Cloning and functional characterization of the rabbit C-C chemokine receptor 2

BMC Immunology, 2005
Background CC-family chemokine receptor 2 (CCR2) is implicated in the trafficking of blood-borne monocytes to sites of inflammation and is implicated in the pathogenesis of several inflammatory diseases such as rheumatoid arthritis, multiple sclerosis ...
Hamdouchi Chafiq, Su Eric W, Wang He, Pappas Amy T, Evans Robert J, Yuan Xiu-juan, Lu Deshun, Venkataraman Chandrasekar   +7 more
doaj   +1 more source

CCR2/CCR5-mediated macrophage–smooth muscle cell crosstalk in pulmonary hypertension

European Respiratory Journal, 2019
Macrophages are major players in the pathogenesis of pulmonary arterial hypertension (PAH). To investigate whether lung macrophages and pulmonary-artery smooth muscle cells (PASMCs) collaborate to stimulate PASMC growth and whether the CCL2-CCR2 and CCL5-
S. Abid, Elisabeth Marcos, A. Parpaleix, V. Amsellem, M. Breau, Amal Houssaini, N. Vienney, M. Lefevre, G. Derumeaux, S. Evans, C. Hubeau, M. Delcroix, R. Quarck, S. Adnot, L. Lipskaia   +14 more
semanticscholar   +1 more source