Results 151 to 160 of about 22,248 (218)

CCR4-NOT Transcription Complex Subunit 3 [PDF]

, 2020
openaire   +1 more source

Composition and function of Ccr4-Not protein complexes

, 2010
Ccr4-Not protein complexes are evolutionarily conserved and have important functions in mRNA regulatory processes. Strict regulation of mRNA’s is important for cells since they form the central connection between the genetic information in the nucleus and active protein production in the cytoplasm.
openaire   +1 more source

Transcription regulation by the human Ccr4-Not proteins

, 2004
Transcription by RNA polymerase II is a highly regulated process. Multiple protein complexes are involved in the regulation of mRNA synthesis. The Ccr4-Not complex regulates transcription at a global level and, most likely, requires other proteins to associate with promoters. The complex is evolutionary conserved from yeast to human.
openaire   +1 more source

CAR T cells targeting CCR4 selectively deplete human Tregs ex vivo and in vivo. [PDF]

Blood Adv
Tilsed CM, Fong KP, Shi X, Akimova T, Wang L, Noguera-Ortega E, Krouse R, Bermudez A, Singhal S, Young R, Eruslanov E, Watanabe K, Hancock WW, June CH, Albelda SM.   +14 more
europepmc   +1 more source

Integrated genetic analyses identified T-cell neoplasms other than adult T-cell leukemia/lymphoma in HTLV-1 carriers. [PDF]

Blood Adv
Naito Y, Yasuda T, Sakihama S, Aiba M, Morichika K, Miyazaki K, Imai H, Masaki A, Tsuyuki T, Shimada S, Yoshimitsu M, Aoyama H, Nakada N, Miyagi T, Tamaki T, Chen BJ, Yuan CT, Fukushima T, Chuang SS, Karube K.   +19 more
europepmc   +1 more source

Peripheral Blood Skin-Homing T Cells Define Immunological Endotypes in Atopic Dermatitis: A Case-Control Study in a Mexican Population. [PDF]

Health Sci Rep
Luis Carlos ZP, Guillermo VS, Andrea Aida VM, Raúl GV, Itzia Azucena RC, Mario Adán ME, Rodolfo PP.   +6 more
europepmc   +1 more source

Human pumilio proteins use fuzzy multivalent hydrophobic interactions to recruit the CCR4-NOT deadenylase complex to repress mRNAs. [PDF]

J Biol Chem
Dunshee EB, Saladin BA, Turner DJ, Qiu C, Dutcher RC, Williams JG, Corbo J, Wolcott OR, Korte AJ, Haugen RJ, Tanaka Hall TM, Valkov E, Goldstrohm AC.   +12 more
europepmc   +1 more source

Circulating ex-Trm CD8 + T cells with skin-homing/chemoattraction phenotype are associated with disease severity in atopic dermatitis. [PDF]

Front Med (Lausanne)
Ordóñez-Rubiano MF, Parra M, Bautista D, Romero-Sánchez C.   +3 more
europepmc   +1 more source

The CCR4–NOT Deadenylase Complex Maintains Adipocyte Identity

The CCR4–NOT Deadenylase Complex Maintains Adipocyte Identity
Shortening of poly(A) tails triggers mRNA degradation; hence, mRNA deadenylation regulates many biological events. In the present study, we generated mice lacking the Cnot1 gene, which encodes an essential scaffold subunit of the CCR4–NOT deadenylase complex in adipose tissues (Cnot1-AKO mice) and we examined the role of CCR4–NOT in adipocyte function.
openaire  

Anti-HER2×CCR4 bispecific antibody enhances antitumor immunity in advanced HER2-positive tumors by chemotaxis blockade and depletion of tumor-associated Tregs, without inducing systemic toxicity. [PDF]

J Immunother Cancer
Wang C, Li J, Tong Y, Chang H, Xu J, Zhu H, Yin Y, Meng M, Xi R.   +8 more
europepmc   +1 more source