Discovery of Drug-like Inhibitors of the Human Caf1/CNOT7 poly(A)-Selective Nuclease Using Compound Screening. [PDF]
Kaur I +3 more
europepmc +1 more source
Multi-Omics Analysis of Human Blood Cells Reveals Unique Features of Age-Associated Type 2 CD8 Memory T Cells. [PDF]
Matsui H +21 more
europepmc +1 more source
Elevated Th1 and terminally differentiated cytotoxic T cells with suppressed Tc17 lymphocytes in lung tissue of advanced COPD and IPF patients undergoing lung transplantation. [PDF]
Šarc I +6 more
europepmc +1 more source
Editorial: Cytokines and chemokines in lymphoma. [PDF]
Kadin ME, Fuschiotti P, Sernicola A.
europepmc +1 more source
The CCR4–NOT complex maintains liver homeostasis through mRNA deadenylation
The biological significance of deadenylation in global gene expression is not fully understood. Here, we show that the CCR4-NOT deadenylase complex maintains expression of mRNAs, such as those encoding transcription factors, cell cycle regulators, DNA damage response-related proteins, and metabolic enzymes, at appropriate levels in the liver.
openaire
Olaparib, durvalumab, and cyclophosphamide, and a prognostic blood signature in platinum-sensitive ovarian cancer: the randomized phase 2 SOLACE2 trial. [PDF]
Lee CK +34 more
europepmc +1 more source
Preserving the Poly(A) Tail: Strategies Viruses Use to 'CYA' (Cover Your A's). [PDF]
Wilusz J.
europepmc +1 more source
"Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway" [PDF]
Lyon, Gholson J.
core
Immunosuppressive tumor microenvironment shape pancreatic cancer unresponsive to current immunotherapies. [PDF]
Li ZY, Peng SY, Li FL, Cai HQ.
europepmc +1 more source

