Results 201 to 210 of about 22,512 (231)

Unraveling the role of chemokines in cutaneous T-cell lymphoma: expression levels at different stages. [PDF]

Front Immunol
Guglielmo A, Zengarini C, Tugnoli F, Zinzani PL, Borghi A, Corazza M, La Placa M, Piraccini BM, Pileri A.   +8 more
europepmc   +1 more source

ICOS⁺ T helper 2 cells promote the pulmonary fibrosis in systemic sclerosis. [PDF]

Mol Med
Zhu H, Chen Y, Wu Y, Zhang Y, Liu S, You N, Liu M, Wang Z, Wang D, Sun L.   +9 more
europepmc   +1 more source

RNA-binding proteins provide specificity to the PAN2–PAN3 mRNA deadenylation complex

Tang TT, Zangari F, Yu CW, Stowell JA, Roeselová A, Freund SM, Gingras A, Passmore LA.   +7 more
europepmc   +1 more source

Ccr4-Not complex: the control freak of eukaryotic cells [PDF]

Critical Reviews in Biochemistry and Molecular Biology, 2012
The purpose of this review is to provide an analysis of the latest developments on the functions of the carbon catabolite-repression 4-Not (Ccr4-Not) complex in regulating eukaryotic gene expression. Ccr4-Not is a nine-subunit protein complex that is conserved in sequence and function throughout the eukaryotic kingdom.
Jason E Miller, Joseph C Reese
exaly   +3 more sources

The Ccr4-Not complex monitors the translating ribosome for codon optimality

Science, 2020
Coupling translation and mRNA decay Gene expression requires messenger RNAs (mRNAs)—DNA-derived blueprints of genes—to be translated by protein-producing ribosomes. The levels of mRNAs are tightly regulated, in part by controlling their half-lives.
Robert Buschauer, Yoshitaka Matsuo, Takato Sugiyama   +2 more
exaly   +4 more sources

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The Ccr4–Not complex

Gene, 2012
The Ccr4-Not complex is a unique, essential and conserved multi-subunit complex that acts at the level of many different cellular functions to regulate gene expression. Two enzymatic activities, namely ubiquitination and deadenylation, are provided by different subunits of the complex.
Collart, Martine, Panasenko, Olesya
openaire   +3 more sources

Novel roles of the CCR4–NOT complex

WIREs RNA, 2014
The CCR4–NOT complex is a multi‐subunit protein complex evolutionarily conserved across eukaryotes which regulates several aspects of gene expression. A fascinating model is emerging in which this complex acts as a regulation platform, controlling gene products ‘from birth to death’ through the coordination of different cellular machineries involved in
Clément, Chapat, Laura, Corbo
openaire   +2 more sources

Deadenylation of cytoplasmic mRNA by the mammalian Ccr4–Not complex

Biochemical Society Transactions, 2012
The Ccr4–Not complex is one of the major deadenylase factors present in eukaryotic cells. This multi-subunit protein complex is composed of at least seven stably associated subunits in mammalian cells including two enzymatic deadenylase subunits: one DEDD (Asp-Glu-Asp-Asp)-type deadenylase (either CNOT7/human Caf1/Caf1a or CNOT8/human Pop2/Caf1b/Calif)
Rachel, Doidge, Saloni, Mittal, Akhmed, Aslam, G Sebastiaan, Winkler   +3 more
openaire   +2 more sources

The essential function of not1 lies within the Ccr4-not complex

Journal of Molecular Biology, 2000
The five Saccharomyces cerevisiae Not proteins are associated with the Ccr4 and Caf1 proteins in 1.2 MDa and 2 MDa complexes. The Not proteins have been proposed to repress transcription of promoters that do not contain a canonical TATA sequence, while the Ccr4 and Caf1 proteins are required for non-fermentative gene expression.
Maillet, Laurent Jean Marie, Tu, Chi, Hong, Y K, Shuster, E O, Collart, Martine   +4 more
openaire   +3 more sources

The CCR4–NOT Complex Plays Diverse Roles in mRNA Metabolism

2003
It is increasingly clear that the synthesis of eukaryotic mRNA involves an integrated series of events involving large multisubunit protein complexes. The evolutionarily conserved CCR4-NOT complex of proteins has been found to be involved in several aspects of mRNA formation, including repression and activation of mRNA initiation, control of mRNA ...
Clyde L, Denis, Junji, Chen
openaire   +2 more sources