Results 211 to 218 of about 22,248 (218)
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Deadenylation of cytoplasmic mRNA by the mammalian Ccr4–Not complex
Biochemical Society Transactions, 2012The Ccr4–Not complex is one of the major deadenylase factors present in eukaryotic cells. This multi-subunit protein complex is composed of at least seven stably associated subunits in mammalian cells including two enzymatic deadenylase subunits: one DEDD (Asp-Glu-Asp-Asp)-type deadenylase (either CNOT7/human Caf1/Caf1a or CNOT8/human Pop2/Caf1b/Calif)
Rachel, Doidge +3 more
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The essential function of not1 lies within the Ccr4-not complex
Journal of Molecular Biology, 2000The five Saccharomyces cerevisiae Not proteins are associated with the Ccr4 and Caf1 proteins in 1.2 MDa and 2 MDa complexes. The Not proteins have been proposed to repress transcription of promoters that do not contain a canonical TATA sequence, while the Ccr4 and Caf1 proteins are required for non-fermentative gene expression.
Maillet, Laurent Jean Marie +4 more
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The CCR4–NOT Complex Plays Diverse Roles in mRNA Metabolism
2003It is increasingly clear that the synthesis of eukaryotic mRNA involves an integrated series of events involving large multisubunit protein complexes. The evolutionarily conserved CCR4-NOT complex of proteins has been found to be involved in several aspects of mRNA formation, including repression and activation of mRNA initiation, control of mRNA ...
Clyde L, Denis, Junji, Chen
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Beyond the known functions of the CCR4‐NOT complex in gene expression regulatory mechanisms
BioEssays, 2016Large protein assemblies are usually the effectors of major cellular processes. The intricate cell homeostasis network is divided into numerous interconnected pathways, each controlled by a set of protein machines. One of these master regulators is the CCR4‐NOT complex, which ultimately controls protein expression levels.
Marta, Ukleja +3 more
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MARTRE: the brake of CCR4-NOT deadenylase
SCIENTIA SINICA VitaeKunMing YAN, Hao YUN, Hong CHENG
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RNA deadenylation by CCR4–NOT controls heart function
Nature Reviews Cardiology, 2018openaire +1 more source
Basic research: RNA deadenylation by CCR4-NOT controls heart function.
Nature reviews. Cardiology, 2020openaire +1 more source