Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family members [PDF]
eLife, 2019 HIV +Elite and Viremic controllers (EC/VCs) are able to control virus infection, perhaps because of host genetic determinants. We identified 16% (21 of 131) EC/VCs with CD4 +T cells with resistance specific to R5-tropic HIV, reversed after introduction ...
Elena Gonzalo-Gil +12 more
doaj +3 more sources
CCR5 Receptor Occupancy Analysis Reveals Increased Peripheral Blood CCR5+CD4+ T Cells Following Treatment With the Anti-CCR5 Antibody Leronlimab [PDF]
Frontiers in Immunology, 2021 CCR5 plays a central role in infectious disease, host defense, and cancer progression, thereby making it an ideal target for therapeutic development. Notably, CCR5 is the major HIV entry co-receptor, where its surface density correlates with HIV plasma ...
Xiao L. Chang +21 more
doaj +3 more sources
Interleukin-10 Promoter and the CCR5 Polymorphisms in Iranian Azari Population with Multiple Sclerosis [PDF]
Iranian Journal of Immunology, 2021 Background: Changes in the expression of cytokines as the result of the single nucleotide polymorphisms (SNPs), can affect the incidence of multiple sclerosis (MS).
Mohammad Asgharzadeh +12 more
doaj +1 more source
Determination of HIV Tropism in Patients with Antiretroviral Therapy Failure in Arkhangelsk Region
Проблемы особо опасных инфекций, 2022 The aim of the study was to determine the tropism of the human immunodeficiency virus in patients with virological failure of antiretroviral therapy (ART) from the Arkhangelsk Region based on the analysis of the env gene V3 loop nucleotide sequence ...
Yu. V. Ostankova +5 more
doaj +1 more source
CCL5 activation of CCR5 regulates cell metabolism to enhance proliferation of breast cancer cells [PDF]
Open Biology, 2016 In earlier studies, we showed that CCL5 enhances proliferation and survival of MCF-7 breast cancer cells in an mTOR-dependent manner and we provided evidence that, for T cells, CCL5 activation of CCR5 results in increased glycolysis and enhanced ATP ...
Darrin Gao +2 more
doaj +1 more source
Accelerated in vivo proliferation of memory phenotype CD4+ T-cells in human HIV-1 infection irrespective of viral chemokine co-receptor tropism. [PDF]
, 2013 CD4(+) T-cell loss is the hallmark of HIV-1 infection. CD4 counts fall more rapidly in advanced disease when CCR5-tropic viral strains tend to be replaced by X4-tropic viruses.
A Kaur +49 more
core +6 more sources
Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection. [PDF]
, 2012 BackgroundLimited knowledge exists on early HIV events that may inform preventive and therapeutic strategies. This study aims to characterize the earliest immunologic and virologic HIV events following infection and investigates the usage of a novel ...
Ananworanich, Jintanat +23 more
core +13 more sources
Specific Substitutions in Region V2 of gp120 env confer SHIV Neutralisation Resistance
Pathogens, 2020 A tier 2 SHIV-MK38 strain was obtained after two in vivo passages of tier 1 SHIV-MK1. SHIV-MK38#818, cloned from the MK38 strain, was neutralisation-resistant, like the parental MK38 strain, to SHIV-infected monkey plasma (MP), HIV-1-infected human ...
Yalcin Pisil +4 more
doaj +1 more source
Cells, 2020 (1) Background: Extracellular nicotinamide phosphoribosyltrasferase (eNAMPT) is released by various cell types with pro-tumoral and pro-inflammatory properties.
Simone Torretta +6 more
doaj +1 more source
RNA Biology, 2023 Gene editing using CRISPR/Cas (clustered regularly interspaced palindromic repeats/CRISPR-associated) is under development as a therapeutic tool for the modification of genes in eukaryotic cells.
David A. Armstrong +5 more
doaj +1 more source