Results 41 to 50 of about 82,628 (226)

Investigation of the Correlation Between the Polymorphism/Expression Level of RANTES and Its Receptor CCR5 Gene Promoter and Type 2 Diabetes Mellitus

Diabetes, Metabolic Syndrome and Obesity, 2023
Jie Chen,1,* Weichang Guo,2,* Hejia Yin,1 Liju Ma,3 Shaoyou Li,4 Huifang Li1 1Department of Diabetes, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, People’s Republic of China; 2Department of Physical Education ...
Chen J, Guo W, Yin H, Ma L, Li S, Li H
doaj  

Cysteine-cysteine chemokine receptor 5 (CCR5) profile of HIV-infected subjects attending University of Calabar Teaching Hospital, Calabar, Southern Nigeria

BMC Infectious Diseases, 2020
Background Cysteine-cysteine chemokine receptor 5 is the main HIV co-receptor involved in the virus and cell-to-cell spread. A variant of the CCR5 gene known as CCR5-Δ32 which is a product of 32 base pair deletion in the gene plays critical role in the ...
Ekerette Friday Ekere, Monday F. Useh, Henshaw Uchechi Okoroiwu, Tatfeng Youtchou Mirabeau   +3 more
doaj   +1 more source

CCR5AS lncRNA variation differentially regulates CCR5, influencing HIV disease outcome. [PDF]

, 2019
Multiple genome-wide studies have identified associations between outcome of human immunodeficiency virus (HIV) infection and polymorphisms in and around the gene encoding the HIV co-receptor CCR5, but the functional basis for the strongest of these ...
Anderson, Stephen K, Carrington, Mary, Chowdhury, Fatema Z, Deeks, Steven G, Ewy, Rodger, Gatanaga, Hiroyuki, Goedert, James J, Haas, David W, Hoots, W Keith, Kirk, Gregory D, Kulkarni, Smita, Kulkarni, Viraj, Le Gall, Sylvie, Lied, Alexandra, Lin, Zhansong, Margolick, Joseph, Martin, Maureen P, McLaren, Paul J, Michael, Nelson, Naranbhai, Vivek, Nguyen, Hoang, Oka, Shinichi, Rucevic, Marijana, Singh, Sukhvinder, Takiguchi, Masafumi, Thio, Chloe L, Viard, Mathias, Walker, Bruce, Walker-Sperling, Victoria, Yu, Xu G, Zou, Chengcheng   +30 more
core  

Mathematical Model of HIV superinfection dynamics and R5 to X4 switch [PDF]

, 2006
During the HIV infection several quasispecies of the virus arise, which are able to use different coreceptors, in particular the CCR5 and CXCR4 coreceptors (R5 and X4 phenotypes, respectively).
Bagnoli, Franco, Lio, Pietro, Sguanci, Luca   +2 more
core   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Frequencies of Circulating Immune Cells in Patients with Parkinson’s Disease: Correlation with MDS-UPDRS Scores

Journal of Integrative Neuroscience
Background: Parkinson’s Disease (PD) is associated with dysregulated/chronic inflammation. The immune system has multiple roles including beneficial effects such as clearing alpha synuclein aggregates.
David Goldeck, Lilly Oettinger, Tamas Fülöp, Claudia Schulte, Klaus Hamprecht, Daniela Berg, Walter Maetzler, Graham Pawelec   +7 more
doaj   +1 more source

CCR5 status and metastatic progression in colorectal cancer

OncoImmunology, 2019
Multiple reports have highlighted the importance of the local immunological cellular composition (i.e. the density of effector T cells and macrophage polarization state) in predicting clinical outcome in advanced metastatic stage of colorectal cancer ...
Meggy Suarez-Carmona, Pornpimol Chaorentong, Jakob Nikolas Kather, Rebecca Rothenheber, Azaz Ahmed, Anna Berthel, Anita Heinzelmann, Rodrigo Moraleda, Nektarios A. Valous, Zeynep Kosaloglu, Rosa Eurich, Jana Wolf, Silke Grauling-Halama, Michael Hundemer, Felix Lasitschka, Fee Klupp, Christoph Kahlert, Alexis Ulrich, Martin Schneider, Christine Falk, Dirk Jäger, Inka Zoernig, Niels Halama   +22 more
doaj   +1 more source

Identifying CCR5 coreceptor populations permissive for HIV-1 entry and productive infection: implications for in vivo studies

Journal of Translational Medicine, 2022
Background The chemokine receptor CCR5 is the major coreceptor for HIV-1 cell entry. We previously observed that not all CCR5 mAbs reduce HIV-1 infection, suggesting that only some CCR5 populations are permissive for HIV-1 entry.
Matthew Weichseldorfer, Yutaka Tagaya, Marvin Reitz, Anthony L. DeVico, Olga S. Latinovic   +4 more
doaj   +1 more source

Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents. [PDF]

, 2018
HIV latency in resting CD4+ T cell represents a key barrier preventing cure of the infection with antiretroviral drugs alone. Latency reversing agents (LRAs) can activate HIV expression in latently infected cells, potentially leading to their elimination
DeChristopher, Brian A, Hardman, Clayton T, Ho, Stephen, Loy, Brian A, Marsden, Matthew D, Navab, Sara M, Ramirez, Christina M, Schrier, Adam J, Shimizu, Akira J, Wender, Paul A, Wu, Xiaomeng, Zack, Jerome A   +11 more
core   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source