Results 71 to 80 of about 82,628 (226)

Fluorescence resonance energy transfer imaging reveals that chemokine-binding modulates heterodimers of CXCR4 and CCR5 receptors. [PDF]

PLoS ONE, 2008
BACKGROUND: Dimerization has emerged as an important feature of chemokine G-protein-coupled receptors. CXCR4 and CCR5 regulate leukocyte chemotaxis and also serve as a co-receptor for HIV entry.
Nilgun Isik, Dale Hereld, Tian Jin
doaj   +1 more source

Two HIV-1 variants resistant to small molecule CCR5 inhibitors differ in how they use CCR5 for entry. [PDF]

PLoS Pathogens, 2009
HIV-1 variants resistant to small molecule CCR5 inhibitors recognize the inhibitor-CCR5 complex, while also interacting with free CCR5. The most common genetic route to resistance involves sequence changes in the gp120 V3 region, a pathway followed when ...
Reem Berro, Rogier W Sanders, Min Lu, Per J Klasse, John P Moore   +4 more
doaj   +1 more source

Envelope-receptor interactions in Nipah virus pathobiology. [PDF]

, 2007
Nipah (NiV) and Hendra (HeV) viruses are members of the newly defined Henipavirus genus of the Paramyxoviridae. Nipah virus (NiV) is an emergent paramyxovirus that causes fatal encephalitis in up to 70% of infected patients, and there is increasing ...
Lee, Benhur
core   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

The frequency of allele CCR5Δ32 in a Serbian population [PDF]

Journal of Medical Biochemistry, 2013
Background: The mutant CCR5Δ32 allele confers resistance to HIV infection. Several hypotheses regarding its origin and persistence in the human population have been proposed.
Đorđević Valentina, Timotijević Gordana, Pruner Iva, Radojković Dragica, Milovanović Boško, Miljković Đorđe   +5 more
doaj  

Regulation of CCR5 expression in human placenta: insights from a study of mother-to-child transmission of HIV in Malawi. [PDF]

PLoS ONE, 2010
Human promoter polymorphisms in the chemokine co-receptor 5 gene (CCR5) have been noted for association with mother-to-child transmission of HIV (HIV MTCT) as well as reduced receptor expression in vitro, but have not been clearly associated with CCR5 ...
Bonnie R Joubert, Nora Franceschini, Victor Mwapasa, Kari E North, Steven R Meshnick   +4 more
doaj   +1 more source

Owl monkey CCR5 reveals synergism between CD4 and CCR5 in HIV-1 entry

Virology, 2017
Studying HIV-1 replication in the presence of functionally related proteins from different species has helped define host determinants of HIV-1 infection. Humans and owl monkeys, but not macaques, encode a CD4 receptor that permits entry of transmissible HIV-1 variants due to a single residue difference. However, little is known about whether divergent
John, Nahabedian, Amit, Sharma, Maryska E, Kaczmarek, Greg K, Wilkerson, Sara L, Sawyer, Julie, Overbaugh   +5 more
openaire   +2 more sources

Diverse immunological roles of liver‐resident immune cells in liver diseases

Precision Medical Sciences, EarlyView.
Based on their origin and functional characteristics, LRICs can be classified into four categories. These cells differ in the focus of their immune functions in liver diseases, yet all exhibit the characteristic of functional bidirectionality.
Zhengyi Fan, Xinqiang Li, Peng Jiang, Dahong Teng, Jinzhen Cai   +4 more
wiley   +1 more source

CCR5 signaling promotes lipopolysaccharide-induced macrophage recruitment and alveolar developmental arrest

Cell Death and Disease, 2021
The pathogenesis of bronchopulmonary dysplasia (BPD), involves inflammatory, mechanisms that are not fully characterized. Here we report that overexpression of C-C chemokine receptor 5 (CCR5) and its ligands is associated with BPD development ...
Ze Chen, Xiaohua Xie, Na Jiang, Jianhui Li, Lei Shen, Yongjun Zhang   +5 more
doaj   +1 more source

Disc‐Toroid Hybrid Lipid Nanoparticles for Efficient Drug Encapsulation and Subcutaneous Delivery

Small, EarlyView.
This study demonstrates sub‐50 nm solid‐lipid nanoparticles with long‐term stability, high drug loading, and strong tissue compatibility. Disc‐toroid morphology is confirmed and may play a role in cellular interactions, while low cytotoxicity and minimal systemic permeation confirm depot‐like behavior. These nanoparticles represent a versatile platform
Zanelle van Niekerk, Rima Nuwayhid, Stefaniya Gaydarova, Eva Bittrich, Natalia Makarova, Susanne Boye, Christo Tzachev, Jan C. Simon, Sandra Franz, Albena Lederer   +9 more
wiley   +1 more source