The frequency of allele CCR5Δ32 in a Serbian population [PDF]
Journal of Medical Biochemistry, 2013 Background: The mutant CCR5Δ32 allele confers resistance to HIV infection. Several hypotheses regarding its origin and persistence in the human population have been proposed.
Đorđević Valentina +5 more
doaj
Breast Cancer Research, 2022 Background CCR5 is a motility chemokine receptor implicated in tumor progression, whose activation and subsequent endocytosis may identify highly aggressive breast cancer cell subtypes likely to spread into the circulatory system.
Ashvathi Raghavakaimal +6 more
doaj +1 more source
Modeling viral infectious diseases and development of antiviral therapies using human induced pluripotent stem cell-derived systems [PDF]
, 2015 The recent biotechnology breakthrough of cell reprogramming and generation of induced pluripotent stem cells (iPSCs), which has revolutionized the approaches to study the mechanisms of human diseases and to test new drugs, can be exploited to generate ...
Barzon, Luisa +6 more
core +2 more sources
From Bench to Bedside: Emerging Paradigms in CAR‐T Cell Therapy for Solid Malignancies
Advanced Science, EarlyView.This review discusses emerging paradigms in CAR‐T cell therapy for solid tumors, emphasizing strategies to overcome therapeutic barriers through synthetic biology, immune engineering, and combinatorial approaches. It highlights advancements in logic gating, modulation of the immune microenvironment, and innovative cell designs, providing valuable ...
Yang Chen +7 more
wiley +1 more source
Class B β-arrestin2-dependent CCR5 signalosome retention with natural antibodies to CCR5 [PDF]
Scientific Reports, 2016 AbstractCCR5 stimulation with natural ligands, such as RANTES, classically induces short-term internalization with transient activation of β-arrestins and rapidly recycling on the cell surface. Here we discovered that, in T cells, natural CCR5 antibodies induce a CCR5-negative phenotype with the involvement of β-arrestin2, which leads to the formation ...
Venuti, A +5 more
openaire +4 more sources
Fluorescence resonance energy transfer imaging reveals that chemokine-binding modulates heterodimers of CXCR4 and CCR5 receptors. [PDF]
PLoS ONE, 2008 BACKGROUND: Dimerization has emerged as an important feature of chemokine G-protein-coupled receptors. CXCR4 and CCR5 regulate leukocyte chemotaxis and also serve as a co-receptor for HIV entry.
Nilgun Isik, Dale Hereld, Tian Jin
doaj +1 more source
Longitudinal sequencing of HIV-1 infected patients with low-level viremia for years while on ART shows no indications for genetic evolution of the virus [PDF]
, 2017 HIV-infected patients on antiretroviral therapy (ART) may present low-level viremia (LLV) above the detection level of current viral load assays.
Dauwe, Kenny +7 more
core +1 more source
Advanced Science, EarlyView.Engineered neutrophil‐derived vesicles (SOD2‐Fer‐1@CVs) co‐delivering antioxidant and ferroptosis‐inhibitory agents enable inflammation‐targeted, ROS‐responsive therapy for ischemia–reperfusion injury in lung transplantation. Synergizing with ex vivo lung perfusion, this strategy alleviates oxidative stress and inflammation, restores vascular integrity,
Hao‐Xiang Yuan +10 more
wiley +1 more source
Effect of CCR5 receptor antagonists on endocytosis of the human CCR5 receptor in CHO‐K1 cells [PDF]
British Journal of Pharmacology, 2008 Background and purpose:The CCR5 chemokine receptor is a member of the G protein‐coupled receptor (GPCR) family that is expressed by macrophages, memory T‐lymphocytes and dendritic cells and is activated by chemotactic proteins (e.g. MIP‐1α [CCL3], MIP‐1β [CCL4] and RANTES [CCL5]).
Stephen J. Hill +3 more
openaire +4 more sources
Two HIV-1 variants resistant to small molecule CCR5 inhibitors differ in how they use CCR5 for entry. [PDF]
PLoS Pathogens, 2009 HIV-1 variants resistant to small molecule CCR5 inhibitors recognize the inhibitor-CCR5 complex, while also interacting with free CCR5. The most common genetic route to resistance involves sequence changes in the gp120 V3 region, a pathway followed when ...
Reem Berro +4 more
doaj +1 more source