Results 81 to 90 of about 90,382 (271)

Owl monkey CCR5 reveals synergism between CD4 and CCR5 in HIV-1 entry

Virology, 2017
Studying HIV-1 replication in the presence of functionally related proteins from different species has helped define host determinants of HIV-1 infection. Humans and owl monkeys, but not macaques, encode a CD4 receptor that permits entry of transmissible HIV-1 variants due to a single residue difference. However, little is known about whether divergent
John, Nahabedian, Amit, Sharma, Maryska E, Kaczmarek, Greg K, Wilkerson, Sara L, Sawyer, Julie, Overbaugh   +5 more
openaire   +2 more sources

Transition From Psoriasis to Psoriatic Arthritis is Characterized by Distinct Alterations in Peripheral Blood Tc17, Th17, and CD4+ Effector Memory Cells

Arthritis &Rheumatology, EarlyView.
Objective Cellular mechanisms driving transition from psoriasis to psoriatic arthritis have remained largely elusive. Thus, we investigated changes within the peripheral blood T cell compartment associated with the transition phase. Methods In an observational study, 116 patients were examined and categorized into subgroups including psoriasis with at ...
Hanna Graßhoff, Sara Comdühr, Henry Nording, Jacob von Esebeck, Philine Letz, Miriam Prohaczka, Handan Gedik, Henner Zirpel, Elisabeth Spallek, Linh Ha‐Wissel, El‐Baraa Adjailia, Sabrina Arnold, Konstantinos Fourlakis, Sebastian Klapa, Ingo Eitel, Oliver J. Müller, Jens Y. Humrich, Gabriela Riemekasten, Diamant Thaçi, Peter Lamprecht   +19 more
wiley   +1 more source

Fluorescence resonance energy transfer imaging reveals that chemokine-binding modulates heterodimers of CXCR4 and CCR5 receptors. [PDF]

PLoS ONE, 2008
BACKGROUND: Dimerization has emerged as an important feature of chemokine G-protein-coupled receptors. CXCR4 and CCR5 regulate leukocyte chemotaxis and also serve as a co-receptor for HIV entry.
Nilgun Isik, Dale Hereld, Tian Jin
doaj   +1 more source

The frequency of allele CCR5Δ32 in a Serbian population [PDF]

Journal of Medical Biochemistry, 2013
Background: The mutant CCR5Δ32 allele confers resistance to HIV infection. Several hypotheses regarding its origin and persistence in the human population have been proposed.
Đorđević Valentina, Timotijević Gordana, Pruner Iva, Radojković Dragica, Milovanović Boško, Miljković Đorđe   +5 more
doaj  

CCR5 signaling promotes lipopolysaccharide-induced macrophage recruitment and alveolar developmental arrest

Cell Death and Disease, 2021
The pathogenesis of bronchopulmonary dysplasia (BPD), involves inflammatory, mechanisms that are not fully characterized. Here we report that overexpression of C-C chemokine receptor 5 (CCR5) and its ligands is associated with BPD development ...
Ze Chen, Xiaohua Xie, Na Jiang, Jianhui Li, Lei Shen, Yongjun Zhang   +5 more
doaj   +1 more source

The comparative value of feline virology research: can findings from the feline lentiviral vaccine be translated to humans? [PDF]

, 2017
Feline immunodeficiency virus (FIV) is a lentivirus of domestic cats that shares several similarities with its human counterpart, human immunodeficiency virus (HIV).
Beczkowski, Paweł M., Harris, Matthes, Hosie, Margaret J., Logan, Nicola, Techakriengkrai, Navapon, Willett, Brian   +5 more
core   +1 more source

Constrained use of CCR5 on CD4+ lymphocytes by R5X4 HIV-1: Efficiency of Env–CCR5 interactions and low CCR5 expression determine a range of restricted CCR5-mediated entry

Virology, 2010
R5X4 HIV-1 has impaired utilization of CCR5 on primary CD4+ lymphocytes but the mechanisms responsible are not well defined. Using a panel of diverse R5X4 Envs we identified a spectrum of CCR5 use on CD4+ lymphocytes. Greater lymphocyte CCR5 use correlated with relative resistance to CCR5 mAbs and small molecule antagonists.
Loftin, Lamorris M., Kienzle, Martha F., Yi, Yanjie, Lee, Benhur, Lee, Fang-Hua, Gray, Lachlan, Gorry, Paul R., Collman, Ronald G.   +7 more
openaire   +2 more sources

Entanglement of CCR5 and Alzheimer’s Disease [PDF]

Frontiers in Aging Neuroscience, 2019
Although the mechanisms of Alzheimer's disease are diverse and unclear, the past 20 years have witnessed the unprecedented development of the AD inflammation theory. As a key inflammatory receptor family, the C-C chemokine receptor family is a remarkable participant in the cause of Alzheimer's disease; of this family, CCR5 is the most widely studied ...
Tianwen Li, Tianwen Li, Tianwen Li, Jianhong Zhu, Jianhong Zhu, Jianhong Zhu   +5 more
openaire   +3 more sources

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

A Cure for HIV Infection: "Not in My Lifetime" or "Just Around the Corner"? [PDF]

, 2016
With the advent and stunning success of combination antiretroviral therapy (ART) to prolong and improve quality of life for persons with HIV infection, HIV research has been afforded the opportunity to pivot towards studies aimed at finding "a cure." The
Cannon, Paula M, Currier, Judith S, Douek, Daniel C, June, Carl H, Kiem, Hans Peter, Kuritzkes, Daniel R, Lederman, Michael M, Lewin, Sharon R, Margolis, David M, McCune, Joseph M, Mellors, John W, Schacker, Timothy W, Sekaly, Rafick P, Tebas, Pablo, Walker, Bruce D   +14 more
core   +2 more sources