Results 141 to 150 of about 51,555 (247)

Explore the Mechanism of Xiaoyaosan for Treatment of Bipolar Disorder Based on Network Pharmacology, Experimental Validation and Molecular Docking

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
This study evaluates Xiaoyaosan (XYS) for bipolar disorder (BD) using network pharmacology and experimental validation. Molecular docking reveals interactions between active XYS compounds and potential core targets. Animal experiments confirm XYS alleviates BD‐like behaviors in mice by suppressing core targets, elucidating its multi‐target mechanism ...
Man Chen, Nana Ding, Xingmin Qiu, Lan Li, Yali Guo, Rongyanqi Wang, Xiaowei Mo, Tan Zou, Shangzhen Yu, Xiaojuan Li, Jiaxu Chen   +10 more
wiley   +1 more source

Pharmacokinetics and Acute Safety Evaluation of Tryptanthrin, A Bioactive Constituent of Indigo naturalis, Following Intravenous Administration in Mice

Journal of Applied Toxicology, Volume 46, Issue 10, Page 3498-3505, October 2026.
ABSTRACT The use of Indigo naturalis in treating inflammatory diseases is clinically restricted by severe adverse events, including pulmonary arterial hypertension and hepatotoxicity. Tryptanthrin, a major indoloquinazoline alkaloid of Indigo naturalis, exhibits potent anti‐inflammatory activity; however, its specific safety profile relative to the ...
Hyung Jin Kim, Gabsik Yang, Jun Ho Lee
wiley   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Advancing In Vivo Chimeric Antigen Receptor T‐Cell Engineering to Accelerate Clinical Translation

MedComm, Volume 7, Issue 10, October 2026.
In vivo CAR‐T cell generation directly engineers endogenous T cells using pre‐manufactured gene delivery vectors that target T cells and deliver CAR‐encoding genetic material. The resulting CAR‐T cells expand in vivo and mediate antigen‐specific cytotoxicity.
Zhenxin Bai, Ming Yi, Shengtao Hu, Dixuan Xue, Luxin Wei, Lifeng Zhang, Zhijun Dai   +6 more
wiley   +1 more source

Ptbp1 Condensates With Phase Separation‐Like Features in Cardiomyocyte Nuclei Regulate Splicing of Proliferative Genes in Neonatal Cardiomyocytes

Development, Growth &Differentiation, Volume 68, Issue 8, October 2026.
Phase‐separated Ptbp1 droplets form molecular complexes containing multiple proliferation‐associated molecules. Ptbp1 granules containing four RNA recognition motifs (RRMs) domains are present in the nuclei of mouse cardiomyocytes specifically during the proliferative stage.
Tai Sada, Akane Sakaguchi, Yoichi Shinkai, Reiko Nakagawa, Chiharu Tanegashima, Mitsutaka Kadota, Takefumi Kondo, Wataru Kimura   +7 more
wiley   +1 more source

The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation

The FEBS Journal, Volume 293, Issue 19, Page 5717-5734, October 2026.
The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak, In‐Ja L. Byeon, Ryan Ponticelli, Mary E. Lucas, Lariah Thompson, Christopher DeHaven, Gary Thomas, Angela M. Gronenborn   +7 more
wiley   +1 more source

Spatially resolved mapping of histones reveals selective neuronal response in Rett syndrome

The FEBS Journal, Volume 293, Issue 19, Page 5814-5836, October 2026.
Rett syndrome (RTT) is a severe neurological disorder caused by loss‐of‐function mutations in the X‐linked MECP2 gene that causes profound life‐long neurological dysfunction. MeCP2 regulates chromatin, yet its influence on histone composition and dynamics is unclear.
Frederike Schäfer, Giuseppina De Rocco, Moritz Völker‐Albert, Ignasi Forne, Nicoletta Landsberger, Axel Imhof, Shibojyoti Lahiri   +6 more
wiley   +1 more source

Entering the Age of Specificity in T Cell Immunity

Immunological Reviews, Volume 343, Issue 1, October 2026.
ABSTRACT The discovery of MHC restriction, the resolution of peptide–MHC structure, and the identification of the T cell receptor gene quickly centered epitope‐level specificity as a core concern of T cell biology. Epitope mapping culminated in functional peptide‐based stimulation assays and tetramer staining, which together provide exquisite ...
Paul G. Thomas
wiley   +1 more source

Contributions of the anion exchangers SLC26A1, SLC26A2, SLC26A3, and SLC26A6 to intestinal oxalate transport in human Caco2‐BBE cells

Physiological Reports, Volume 14, Issue 19, October 2026.
Abstract Kidney stones affect ~1 in 5 men and 1 in 11 women, with 70%–80% being composed of calcium oxalate. Knowing the contributions of anion exchangers SLC26A2 (A2), A3, and A6 to apical and A1 to basolateral oxalate transport in human intestinal Caco2‐BBE (C2) cells is important since enhancing intestinal oxalate secretion (A6/2/?A1) and reducing ...
Khalid A. Abdelhalim, Donna Arvans, Yanzhe Wang, Mohamed Elfatih H. Bashir, Hatim A. Hassan   +4 more
wiley   +1 more source

Evaluating the Validity of Model Organisms: A Review and a New Framework for Biologists

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
This article provides an overview on model organisms and proposes a new framework for assessing the extent to which it is justified to generalize the results obtained from a given organism. It covers both studies of human diseases and those focused on general biological processes. The first part of the article is a review on model organisms.
Héloïse Athéa, Nicolas Heck
wiley   +1 more source