Results 71 to 80 of about 51,555 (247)

Studies on polymorphic alu insertions and genomic diversity within the major histocompatibility complex [PDF]

, 2005
After the initiation of the human genome sequencing project and the introduction of the field of 'bioinformatics', interest in human genetic diversity studies has been increased.
Dunn, David Suliman
core  

Structural Dynamics of the Lipid Antigen-Binding Site of CD1d Protein

Biomolecules, 2020
CD1 molecules present lipid antigens to T-cells in early stages of immune responses. Whereas CD1‒lipid‒T-cell receptors interactions are reasonably understood, molecular details on initial trafficking and loading of lipids onto CD1 proteins are less ...
Bruno Cuevas-Zuviría, Marina Mínguez-Toral, Araceli Díaz-Perales, María Garrido-Arandia, Luis F. Pacios   +4 more
doaj   +1 more source

Mapping Embryonic Mouse Lung Development Using Enhanced Spatial Transcriptomics

Advanced Science, EarlyView.
The mammalian lung contains ∼50 cell types arranged along the airway epithelium. Here, deterministic barcoding sequencing (DBiT‐seq) is optimized to nearly double transcript recovery, enabling highly sensitive spatial mapping of the embryonic mouse lung.
Pengfei Zhang, Benjamin K. Law, Niles Huang, Katharine Goodwin, Celeste M. Nelson, Michelle M. Chan   +5 more
wiley   +1 more source

Strain differences in cuprizone induced demyelination

Cell & Bioscience, 2017
Background Multiple sclerosis (MS) is a severe neurological disorder, characterized by demyelination of the central nervous system (CNS), and with a prevalence of greater than 2 million people worldwide.
Qili Yu, Ryan Hui, Jiyoung Park, Yangyang Huang, Alexander W. Kusnecov, Cheryl F. Dreyfus, Renping Zhou   +6 more
doaj   +1 more source

Critical Roles of O‐Acetylation Revealed by Synthetic Trisaccharide Antigens for a Broad‐Spectrum Anti‐Salmonella Vaccine

Advanced Science, EarlyView.
A synthetic glycoconjugate vaccine based on a diacetylated Salmonella trisaccharide elicits broadly protective antibodies against four major human pathogenic serovars. Mechanistic studies identify 2,3‐di‐O‐acetylation of rhamnose as a critical determinant of antigen recognition and breadth of protection, establishing a new strategy for broad‐spectrum ...
Xingling Pan, Soham Maity, Herbert Kavunja, Yuvarani Murali, Ting‐An Chen, Chang‐xin Huo, Scott M. Baliban, Xuefei Huang   +7 more
wiley   +1 more source

Effect of Laser on the Bound Magnetic Polaron in a Semimagnetic Quantum Wire [PDF]

Журнал нано- та електронної фізики, 2011
In the present investigation binding energy of the laser dressed hydrogenic donor in a Semi magnetic Quantum Wire like Cd1 – xMnx2Te/Cd1 – x1Mnx1Te/Cd1 – x2Mnx2Te and spin polaronic shift has been computed for various magnetic and laser fields within the
C. Raja Mohan, K. Jayakumar
doaj  

Lipid-Reactive T Cells in Immunological Disorders of the Lung

Frontiers in Immunology, 2018
Regulation of T cell-mediated immunity in the lungs is critical for prevention of immune-related lung disorders and for host protection from pathogens.
Seungwon Ryu, Seungwon Ryu, Joon Seok Park, Hye Young Kim, Hye Young Kim, Ji Hyung Kim   +5 more
doaj   +1 more source

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng, Wen Gao, Jonathan Do, Danli Lu, Ying‐Wei Lan, Andreas Damianos, Gautam Verma, Ali Al Siraj, Isabella Lowry, Lance Peter, Nicholas E. Banovich, Fei Sun, Hua He, Tanya V. Kalin, Vladimir V. Kalinichenko   +14 more
wiley   +1 more source

Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease

Advanced Science, EarlyView.
Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken, Paula Beltran Lobo, Yunzhao Wu, Lyla A. Rowe, Emre Fertan, Cara L. Croft, Maria Jimenez‐Sanchez, Dezerae Cox, David Klenerman   +8 more
wiley   +1 more source

Alteration of CD1 expression in multiple sclerosis

, 2012
International audienceStudies of multiple sclerosis (MS) have concentrated mainly on antigen pre-sentation of peptides derived from the myelin sheath, while the implication of lipid antigen has been less explored in this pathology.
Boucraut, José, Mooney, Nuala, Charron, Dominique, Mooney, N., Malikova, I., Gelin, Catherine, Charron, D., Gelin, C., Bine, Sébastien, Haziot, Alain, Pelletier, J, Bine, S., Haziot, A., Pelletier, Jean, Malikova, I, Boucraut, J.   +15 more
core   +1 more source