Epigenetic regulation of CD133 and tumorigenicity of CD133 positive and negative endometrial cancer cells [PDF]
Reproductive Biology and Endocrinology, 2010 Background Recent data provide significant evidence to support the hypothesis that there are sub-populations of cells within solid tumors that have an increased tumor initiating potential relative to the total tumor population.
Borger Darrell R +10 more
doaj +3 more sources
Advances in Aptamer Drug Delivery Systems for Treatment of Glioblastoma. [PDF]
Adv Sci (Weinh)Aptamers have remarkable recognition capacity which is suitable for assisting drug delivery for GB. This review demonstrates that aptamers have great potential as targeted therapeutic carriers, conjugated to various therapeutic carriers, using a range of conjugation strategies and chemistries.
Paul AR +4 more
europepmc +2 more sources
The role of CD133 in hepatocellular carcinoma [PDF]
Cancer Biology & Therapy, 2021 Cancer stem cells (CSCs) represent a small subpopulation of cells found within tumors that exhibit properties of self-renewal, like normal stem cells. CSCs have been defined as a crucial factor involved in driving cancer relapse, chemoresistance and metastasis.
Fengchao Liu, Yanzhi Qian
openaire +2 more sources
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
CD133 expression is not restricted to stem cells, and both CD133+ and CD133– metastatic colon cancer cells initiate tumors [PDF]
Journal of Clinical Investigation, 2008 Colon cancer stem cells are believed to originate from a rare population of putative CD133+ intestinal stem cells. Recent publications suggest that a small subset of colon cancer cells expresses CD133, and that only these CD133+ cancer cells are capable of tumor initiation. However, the precise contribution of CD133+ tumor-initiating cells in mediating
Sergey V, Shmelkov +19 more
openaire +2 more sources
A Metabolic-Epigenetic Axis of AARS1/IGF2BP3-K280 Lactylation Sustains Endometrial Cancer Stemness and Recurrence. [PDF]
Adv Sci (Weinh)Lactate‐driven endometrial cancer relapse is mediated by enzymatic protein modification. Elevated lactate levels activate AARS1, which catalyzes K280 lactylation of IGF2BP3, therefore stabilizing HMGA2 mRNA and promoting tumor stemness and recurrence.
Jiang P +11 more
europepmc +2 more sources
CD133 Role in Oral Carcinogenesis [PDF]
Asian Pacific Journal of Cancer Prevention, 2020 to investigate CD133 immunoexpression, cancer stem cells marker, in oral epithelial dysplasias (OEDs) and oral squamous cells carcinomas (OSCCs) and understandits possible involvement in the malignant transformation process of these lesions and to better elucidate their biological behavior.Tissue samples of 15 cases of OSCCs and 15 OEDs were subjected ...
Luna, Ealber Carvalho Macedo +7 more
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Oxytetracycline have the therapeutic efficiency in CD133+ HCC population through suppression CD133 expression by decreasing of protein stability of CD133 [PDF]
Scientific Reports, 2018 AbstractCancer stem cells (CSCs) are considered a serious sub-population in cancer tissues because of their strong resistance to conventional chemotherapy and radiotherapy. Thus, the current advancements in the use of liver cancer stem cells (LCSC) to develop efficient and organized means to an antitumor agent is quickly gaining recognition as a novel ...
Song, Yeonhwa +4 more
openaire +2 more sources
CD133 expression in osteosarcoma and derivation of CD133+ cells
Molecular Medicine Reports, 2012 Cluster of differentiation 133 (CD133) is recognized as a stem cell marker for normal and cancerous tissues. Using cell culture and real‑time fluorescent polymerase chain reaction, CD133 expression was analyzed in osteosarcoma tissue and Saos‑2 cell lines.
Ji, Li +7 more
openaire +3 more sources
The stem cell marker CD133 associates with enhanced colony formation and cell motility in colorectal cancer. [PDF]
PLoS ONE, 2010 CD133 is a membrane molecule that has been, controversially, reported as a CSC marker in colorectal cancer (CRC). In this study, we sought to clarify the expression and role of CD133 in CRC.
Tarek M A Elsaba +9 more
doaj +1 more source