Results 31 to 40 of about 33,329 (197)
Drug Design, Development and Therapy, 2021 Yaqin Zhang, 1,* Ruofei Chen, 1,* Lili Deng, 2 Zongwen Shuai, 1 Mingwei Chen 2 1Department of Rheumatology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, People’s Republic of China; 2Department of Endocrinology,
Zhang Y, Chen R, Deng L, Shuai Z, Chen M
doaj
Iterative sorting reveals CD133+ and CD133- melanoma cells as phenotypically distinct populations [PDF]
BMC Cancer, 2016 The heterogeneity and tumourigenicity of metastatic melanoma is attributed to a cancer stem cell model, with CD133 considered to be a cancer stem cell marker in melanoma as well as other tumours, but its role has remained controversial.We iteratively sorted CD133+ and CD133- cells from 3 metastatic melanoma cell lines, and observed tumourigenicity and ...
Grasso, C. +9 more
openaire +4 more sources
Identification of CD133-positive radioresistant cells in atypical teratoid/rhabdoid tumor. [PDF]
PLoS ONE, 2008 Atypical teratoid/rhabdoid tumor (AT/RT) is an extremely malignant neoplasm in the central nervous system (CNS) which occurs in infancy and childhood. Recent studies suggested that CD133 could be considered a marker for brain cancer stem-like cells (CSCs)
Shih-Hwa Chiou +9 more
doaj +1 more source
Angewandte Chemie, EarlyView.DE‐CQ, an NAD(P)H‐activatable theranostic probe, enables the quantification of cancer aggressiveness via glucose‐stimulated fluorescence imaging and selectively induces apoptosis. Its multifaceted efficacy is demonstrated across 2D cells, 3D spheroids, and in vivo models.
Yujin Cha +11 more
wiley +2 more sources
Valproic Acid Increases CD133 Positive Cells that Show Low Sensitivity to Cytostatics in Neuroblastoma. [PDF]
PLoS ONE, 2016 Valproic acid (VPA) is a well-known antiepileptic drug that exhibits antitumor activities through its action as a histone deacetylase inhibitor. CD133 is considered to be a cancer stem cell marker in several tumors including neuroblastoma.
Mohamed Ashraf Khalil +5 more
doaj +1 more source
The importance of the stem cell marker prominin-1/CD133 in the uptake of transferrin and in iron metabolism in human colon cancer Caco-2 cells. [PDF]
PLoS ONE, 2011 As the pentaspan stem cell marker CD133 was shown to bind cholesterol and to localize in plasma membrane protrusions, we investigated a possible function for CD133 in endocytosis.
Erika Bourseau-Guilmain +3 more
doaj +1 more source
Non-invasive in vivo imaging of tumor-associated CD133/prominin. [PDF]
PLoS ONE, 2010 Cancer stem cells are thought to play a pivotal role in tumor maintenance, metastasis, tumor therapy resistance and relapse. Hence, the development of methods for non-invasive in vivo detection of cancer stem cells is of great importance.Here, we ...
Chizuko Tsurumi +9 more
doaj +1 more source
Clinical, Cosmetic and Investigational Dermatology, 2022 Yalan Bi,1 Xiaohua Shi,2 Dian Chen,1 Yi Zhao1 1Department of Dermatology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, People’s Republic of China; 2Department of Pathology, Peking Union Medical College ...
Bi Y, Shi X, Chen D, Zhao Y
doaj
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source