Results 41 to 50 of about 188,530 (334)

A TLR4-independent critical role for CD14 in intracellular LPS sensing

Cell Reports, 2022
Summary: Intracellular lipopolysaccharide (LPS) sensing by the noncanonical inflammasome comprising caspase-4 or -11 governs antibacterial host defense. How LPS gains intracellular access in vivo is largely unknown. Here, we show that CD14—an LPS-binding
Swathy O. Vasudevan, Ashley J. Russo, Puja Kumari, Sivapriya Kailasan Vanaja, Vijay A. Rathinam   +4 more
doaj   +1 more source

Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS. [PDF]

, 1994
Lipoproteins isolated from normal human plasma can bind and neutralize bacterial lipopolysaccharide (LPS) and may represent an important mechanism in host defense against gram-negative septic shock. Recent studies have shown that experimentally elevating
Kane, JP, Kunitake, ST, Lichenstein, H, Wright, SD, Wurfel, MM   +4 more
core   +1 more source

Serum CD14 concentration is associated with obesity and insulin resistance in non-diabetic individuals

Journal of International Medical Research, 2022
Objective CD14 is a lipopolysaccharide-binding protein that serves as a marker of monocytes. The role of circulating CD14 in patients with obesity without diabetes remains unknown. Here, we characterized the relationships between serum CD14 concentration
Yea Eun Kang, Kyong Hye Joung, Ji Min Kim, Ju Hee Lee, Hyun Jin Kim, Bon Jeong Ku   +5 more
doaj   +1 more source

Chemical Composition of Young Stars in the Leading Arm of the Magellanic System

, 2017
Chemical abundances of eight O- and B-type stars are determined from high-resolution spectra obtained with the MIKE instrument on the Magellan 6.5m Clay telescope.
Bidin, Christian Moni, Casetti-Dinescu, Dana I., Girard, Terrence M., Korchagin, Vladimir I., Méndez, Réne A., van Altena, William F., Vieira, Katherine, Zhang, Lan, Zhao, Gang   +8 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Role of CD14 in a mouse model of acute lung inflammation induced by different lipopolysaccharide chemotypes. [PDF]

PLoS ONE, 2010
BACKGROUND: Recognition of lipopolysaccharide (LPS) is required for effective defense against invading gram-negative bacteria. Recently, in vitro studies revealed that CD14 is required for activation of the myeloid differentiation factor (MyD)88 ...
Adam A Anas, Joppe W R Hovius, Cornelis van 't Veer, Tom van der Poll, Alex F de Vos   +4 more
doaj   +1 more source

Expression and regulation of macrophage-inducible C-type lectin in human synovial macrophages

Central European Journal of Immunology, 2021
Recent evidence suggests that synovial macrophage activation may be involved in cartilage destruction and pain in osteoarthritis (OA). The macrophage-inducible C-type lectin (Mincle) Clec4e is expressed in macrophages and is regulated in inflammatory ...
Mitsutoshi Moriya, Kentaro Uchida, Shotaro Takano, Dai Iwase, Gen Inoue, Manabu Muaki, Ryo Tazawa, Jun Aikawa, Hiroyuki Sekiguchi, Masashi Takaso   +9 more
doaj   +1 more source

CD14 expression and soluble CD14 after segmental allergen provocation in atopic asthma [PDF]

European Respiratory Journal, 1998
Allergic asthma is associated with the recruitment of activated inflammatory cells after allergen challenge. Surface expression of CD14 has been proposed as a marker of cell activation and differentiation. We therefore measured CD14 expression on activated macrophages and granulocytes as well as soluble CD14 (sCD14) concentrations in peripheral blood ...
Virchow, Johann Christian, Julius, Peter, Matthys, Heinrich M., Kroegel, Claus, Luttmann, Werner   +4 more
openaire   +3 more sources

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Effects of hepatocyte CD14 upregulation during cholestasis on endotoxin sensitivity. [PDF]

PLoS ONE, 2012
Cholestasis is frequently related to endotoxemia and inflammatory response. Our previous investigation revealed a significant increase in plasma endotoxin and CD14 levels during biliary atresia.
Ming-Huei Chou, Jiin-Haur Chuang, Hock-Liew Eng, Po-Chin Tsai, Chih-Sung Hsieh, Hsiang-Chun Liu, Chiou-Huey Wang, Chih-Yun Lin, Tsun-Mei Lin   +8 more
doaj   +1 more source