Results 41 to 50 of about 7,732 (197)

Diverging prognostic effects of CD155 and CD73 expressions in locally advanced triple-negative breast cancer

Frontiers in Oncology, 2023
BackgroundImmune checkpoint inhibition, combined with novel biomarkers, may provide alternative pathways for treating chemotherapy-resistant triple-negative breast cancer (TNBC).
Neslihan Cabioglu, Aysel Bayram, Selman Emiroglu, Semen Onder, Huseyin Karatay, Huseyin Karatay, Gizem Oner, Gizem Oner, Gizem Oner, Mustafa Tukenmez, Mahmut Muslumanoglu, Abdullah Igci, Abdullah Igci, Adnan Aydiner, Pinar Saip, Ekrem Yavuz, Vahit Ozmen, Vahit Ozmen   +17 more
doaj   +1 more source

The IMiDs targets IKZF-1/3 and IRF4 as novel negative regulators of NK cell-activating ligands expression in multiple myeloma [PDF]

, 2015
Immunomodulatory drugs (IMiDs) have potent anti-tumor activities in multiple myeloma (MM) and are able to enhance the cytotoxic function of natural killer (NK) cells, important effectors of the immune response against MM.
Abruzzese, MARIA PIA, Cecere, Francesca, Cippitelli, Marco, Fionda, Cinzia, Molfetta, Rosa, Paolini, Rossella, Peruzzi, Giovanna, Petrucci, MARIA TERESA, Ricciardi, Maria Rosaria, Santoni, Angela, Soriani, Alessandra, Vulpis, Elisabetta, Zingoni, Alessandra   +12 more
core   +2 more sources

Immunohistochemical expression of CD155 in invasive female breast carcinoma and its correlation with tumor infiltrating natural killer cells

Beni-Suef University Journal of Basic and Applied Sciences, 2023
Background CD155 is an immune checkpoint protein that interacts with ligands on natural killer cells to regulate the tumor associated immunity. CD155 overexpression has been detected in many human cancer types.
Passant Essam Eldin Shibel, Eman Ahmed Abd Elmaogod   +1 more
doaj   +1 more source

Prognostic factors of resected pathological stage I lung adenocarcinoma: evaluating subtypes and PD-L1/CD155 expression

Scientific Reports, 2023
We aimed to compare the prognostic impacts of adenocarcinoma subtypes, programmed death-ligand I (PD-L1), and CD155 expression on patients with resected pathological stage (p-stage) I lung adenocarcinoma. In total, 353 patients with completely resected p-
Natsumasa Nishizawa, Shohei Shimajiri, Rintaro Oyama, Takehiko Manabe, Yukiko Nemoto, Hiroki Matsumiya, Yohei Honda, Akihiro Taira, Masaru Takenaka, Koji Kuroda, Fumihiro Tanaka   +10 more
doaj   +1 more source

Innate immune activating ligand SUMOylation affects tumor cell recognition by NK cells [PDF]

, 2017
Natural Killer cells are innate lymphocytes involved in tumor immunosurveillance. They express activating receptors able to recognize self-molecules poorly expressed on healthy cells but up-regulated upon stress conditions, including transformation ...
Cippitelli, M, De Turris, V, Fionda, C, Gismondi, A, Lecce, M, Molfetta, R°, Paolini, R, Petrucci, Mt, Quatrini, L, Ricciardi, Mr, Santoni, A, Stabile, H, Zitti, B°, °these Authors Contributed Equally To The, Work   +13 more
core   +1 more source

Tumor rejection by the poliovirus receptor family ligands of the DNAM-1(CD226) receptor [PDF]

, 2006
The poliovirus receptor CD155 and its family member CD112 (nectin-2) are the ligands for the activating cell-surface receptor DNAM-1 on CD8(+) T cells and natural killer (NK) cells. Here, we demonstrate that, whereas the RMA tumor grew in syngeneic mice,
Honda Shin-ichiro, Kai Hirayasu, Miyamoto Akitomo, Morikawa Yoshihiro, Ohkochi Nobuhiro, Shibuya Akira, Shibuya Kazuko, Tahara-Hanaoka Satoko, 本多 伸一郎, 渋谷 和子, 渋谷 彰, 田原 聡子, 甲斐 平康   +12 more
core   +1 more source

Blocking TIGIT/CD155 signalling reverses CD8+ T cell exhaustion and enhances the antitumor activity in cervical cancer

Journal of Translational Medicine, 2022
Objective TIGIT/CD155 has attracted widespread attention as a new immune checkpoint and a potential target for cancer immunotherapy. In our study, we evaluated the role of TIGIT/CD155 checkpoints in the progression of cervical cancer.
Lu Liu, Aihong Wang, Xiaoli Liu, Sai Han, Yu Sun, Junhua Zhang, Lingyu Guo, Youzhong Zhang   +7 more
doaj   +1 more source

Identification and characterization of murine DNAM-1 (CD226) and its poliovirus receptor family ligands [PDF]

, 2005
journal ...
Hara Ayumi, Honda Shin-ichiro, Miyamoto Akitomo, SHIBUYA Akira, SHIBUYA Kazuko, TAHARA Satoko   +5 more
core   +1 more source

Plasma membrane profiling defines an expanded class of cell surface proteins selectively targeted for degradation by HCMV US2 in cooperation with UL141. [PDF]

, 2015
Human cytomegalovirus (HCMV) US2, US3, US6 and US11 act in concert to prevent immune recognition of virally infected cells by CD8+ T-lymphocytes through downregulation of MHC class I molecules (MHC-I). Here we show that US2 function goes far beyond MHC-I
Antrobus, Robin, Davison, Andrew J, Hsu, Jye-Lin, Lehner, Paul J, Ruckova, Eva, Stanton, Richard J, Sugrue, Daniel, Tomasec, Peter, van den Boomen, Dick JH, Weekes, Michael P, Wilkie, Gavin S, Wilkinson, Gavin WG   +11 more
core   +5 more sources

Prognostic and clinicopathological significance of CD155 expression in cancer patients: a meta-analysis

World Journal of Surgical Oncology, 2022
Background It has been previously reported that CD155 is often over-expressed in a variety of cancer types. In fact, it is known to be involved in cancer development, and its role in cancer has been widely established.
Dan Zhang, Jingting Liu, Mengxia Zheng, Chunyan Meng, Jianhua Liao   +4 more
doaj   +1 more source