Results 81 to 90 of about 98,093 (297)

Overexpression of CD64 on CD14++CD16‑ and CD14++CD16+ monocytes of rheumatoid arthritis patients correlates with disease activity

Experimental and Therapeutic Medicine, 2018
It is well-known that monocytes are a heterogeneous cell population and different monocyte subsets play important roles in rheumatoid arthritis (RA). Cluster of differentiation (CD)64 is one of Fc receptor, which initiates immunological and inflammatory reactions. However, the roles in RA remain to be elucidated. In the present study, the expression of
Qing, Luo, Pengcheng, Xiao, Xue, Li, Zhen, Deng, Cheng, Qing, Rigu, Su, Jianqing, Xu, Yang, Guo, Zikun, Huang, Junming, Li   +9 more
openaire   +3 more sources

Generation and characterization of monoclonal antibodies to equine CD16 [PDF]

Veterinary Immunology and Immunopathology, 2012
The low-affinity Fc receptor CD16 plays a central role in the inflammatory and innate immune responses of many species, but has not yet been investigated in the horse. Using the predicted extracellular region of equine CD16 expressed as a recombinant fusion protein with equine IL-4 (rIL-4/CD16), we generated a panel of mouse monoclonal antibodies (mAbs)
Leela E, Noronha, Rebecca M, Harman, Bettina, Wagner, Douglas F, Antczak   +3 more
openaire   +2 more sources

Minocycline inhibition of monocyte activation correlates with neuronal protection in SIV neuroAIDS.

PLoS ONE, 2011
BackgroundMinocycline is a tetracycline antibiotic that has been proposed as a potential conjunctive therapy for HIV-1 associated cognitive disorders. Precise mechanism(s) of minocycline's functions are not well defined.MethodsFourteen rhesus macaques ...
Jennifer H Campbell, Tricia H Burdo, Patrick Autissier, Jeffrey P Bombardier, Susan V Westmoreland, Caroline Soulas, R Gilberto González, Eva-Maria Ratai, Kenneth C Williams   +8 more
doaj   +1 more source

Effect of Interleukin-17 in the Activation of Monocyte Subsets in Patients with ST-Segment Elevation Myocardial Infarction

Journal of Immunology Research, 2020
Interleukin- (IL-) 17 is increased in acute myocardial infarction (AMI) and plays a key role in inflammatory diseases through its involvement in the activation of leukocytes.
Montserrat Guadalupe Garza-Reyes, Mónica Daniela Mora-Ruíz, Luis Chávez-Sánchez, Alejandra Madrid-Miller, Alberto Jose Cabrera-Quintero, José Luis Maravillas-Montero, Alejandro Zentella-Dehesa, Luis Moreno-Ruíz, Selene Pastor-Salgado, Erick Ramírez-Arias, Nataly Pérez-Velázquez, Adriana Karina Chávez-Rueda, Francisco Blanco-Favela, Wendy Guadalupe Vazquez-Gonzalez, Alicia Contreras-Rodríguez   +14 more
doaj   +1 more source

Differential expression of CD163 on monocyte subsets in healthy and HIV-1 infected individuals. [PDF]

PLoS ONE, 2011
CD163, a haptoglobin-hemoglobin (Hp-Hb) scavenger receptor, expressed by monocytes and macrophages, is important in resolution of inflammation. Age-related non-AIDS co-morbidities in HIV-infected individuals, particularly dementia and cardiovascular ...
Emma Tippett, Wan-Jung Cheng, Clare Westhorpe, Paul U Cameron, Bruce J Brew, Sharon R Lewin, Anthony Jaworowski, Suzanne M Crowe   +7 more
doaj   +1 more source

Immediate Growth Control in Response to Boiling Histotripsy is Prognostic for Intratumoral Immune Activation

Advanced Science, EarlyView.
Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger, Matthew R. DeWitt, Carly M. Van Wagoner, Claire A. Conarroe, Charles C. Funk, Aaron B. Streit, AeRyon Kim, Richard J. Price, Timothy N. J. Bullock   +8 more
wiley   +1 more source

Dysfunction of CD3 − CD16 + CD56 dim and CD3 − CD16 − CD56 bright NK cell subsets in RR-MS patients

Clinical Immunology, 2018
Abstract Multiple sclerosis (MS), is a chronic inflammatory disease of central nervous system with unclear etiology. Relapsing-remitting (RR)-MS is the most frequent subtype of disease. Natural Killer (NK) cells have roles in cytotoxicity and immune regulation by cytokine secretions, with uncertain contribution to MS pathogenesis. This study aimed to
Tahrali, Ilhan, Kucuksezer, Umut Can, Altintas, Ayse, Uygunoglu, Ugur, Akdeniz, Nilgun, Aktas-Cetin, Esin, Deniz, Gunnur   +6 more
openaire   +4 more sources

CD16+ as predictive marker for early relapse in aggressive B-NHL/DLBCL patients

Molecular Cancer
Assessing the prognosis of patients with aggressive non-Hodgkin B cell lymphoma mainly relies on a clinical risk score (IPI). Standard first-line therapies are based on a chemo-immunotherapy with rituximab, which mediates CD16-dependent antibody ...
Sylvia Zöphel, Nadja Küchler, Johanna Jansky, Cora Hoxha, Gertrud Schäfer, Julius J. Weise, Joanne Vialle, Lea Kaschek, Gebhard Stopper, Hermann Eichler, Daniela Yildiz, Alina Moter, Philipp Wendel, Evelyn Ullrich, Claudia Schormann, Torben Rixecker, Onur Cetin, Frank Neumann, Patrick Orth, Moritz Bewarder, Markus Hoth, Lorenz Thurner, Eva C. Schwarz   +22 more
doaj   +1 more source

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source

Upregulation of CD69 and CCR5 expression on CD16⁺ and CD16⁻ monocyte subsets.

, 2013
(A) PBMC from AIDS subjects were stained with fluorochrome-conjugated Abs. CD14 and CD16 expression identified three Mo subsets: CD14highCD16− (gate R2), CD14highCD16+ (gate R3), and CD14lowCD16+ (gate R4).
Megan Mefford (93072), David Stone (93071), Steven M. Wolinsky (16520), Anupa Kamat (93067), Elyse J. Singer (93074), Tauheed Zaman (93070), Alysse Wurcel (93069), Dana Gabuzda (77886), Susan Morgello (93073), Patrick Autissier (93068), Kevin J. Kunstman (16518), Petronela Ancuta (93066), Eun-Young Kim (16515)   +12 more
core   +1 more source