Results 71 to 80 of about 98,093 (297)

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

활성 혈소판에 의하여 CD14+CD16‒ 단핵구가 강화된 FcγR 매개 식세포 작용 및 M2 대식세포 특성을 가지는 CD14+CD16+ 단핵구로 전환되는 기전 연구 [PDF]

, 2022
학위논문(석사) -- 서울대학교대학원 : 의과대학 의과학과, 2022. 8. 이원우.단핵구는 선천 면역 방어체계의 중요한 세포이다. 인간 단핵구는 다양한 종류가 존재하고, 특히 CD14 및 CD16 발현에 따라 크게 3가지로 분류된다. CD14+CD16+ 단핵구 증가가 류마티스 관절염을 포함한 만성 염증성 질환에서 꾸준히 보고되었으나, 전형적인 단핵구인 CD14+CD16‒ 단핵구에서 CD16 유도기전과 그 역할에 대해서는 알려진 바가 많지 않다.
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core  

Flow cytometric analysis of lymphocyte subsets, monocytes, and HLA-DR expressions on these cells in patients with COVID-19

Türk Biyokimya Dergisi
We aimed to investigate the lymphocyte subsets and monocytes by flow cytometry and the correlations between their HLA-DR expressions and inflammatory markers in patients with COVID-19.
Ozcan Nurgul, Caglayan Murat, Yalcindag Ali, Ozcan Oguzhan   +3 more
doaj   +1 more source

Sustained immune complex-mediated reduction in CD16 expression after vaccination regulates NK cell function

Frontiers in Immunology, 2016
Cross-linking of FcγRIII (CD16) by immune complexes induces antibody dependent cellular cytotoxicity (ADCC) by natural killer (NK) cells, contributing to control of intracellular pathogens; this pathway can also be targeted for immunotherapy of cancerous
Martin R Goodier, Chiara Lusa, Sam Sherratt, Ana Rodriguez-Galan, Ron Behrens, Eleanor M Riley   +5 more
doaj   +1 more source

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen, Cong Zhang, Song Xue, Yuan Zeng, Haochen Cui, Chenfei Wang, Jiayi Feng, Lei Yan, Yuanwei Zang   +8 more
wiley   +1 more source

Self‐Assembly of Antigenic Peptide Nanofibrils Templates the Growth of Silica Nanoparticles for Nanovaccines

Advanced Science, EarlyView.
Antigenic peptides Aβ42 and E7 self‐assemble into nanofibrils; APTES and TEOS induce SiO2 NP formation on these fibrils to form SiO2@fibril nanovaccines, which activate BMDCs in vitro. In vivo, SiO2@Aβ42 fibril nanovaccines alleviate AD symptoms and clear Aβ42 plaques in APP/PS1 mice, and SiO2@E7 fibril nanovaccines inhibit tumor growth and promote ...
Xuecheng Yang, Min Li, Zhiying Yao, Yu Hu, Zhili Wang, Wendi Shi, Bingbing Sun   +6 more
wiley   +1 more source

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Chronic HBV Infection Disrupts CCL5‐Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV‐Specific T Cells

Advanced Science, EarlyView.
ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.
Ailu Yang, Yucan Wang, Yating Yu, Jing Wu, Cuiping Bao, Zixuan Wang, Qiuju Han, Zhigang Tian, Jian Zhang, Huajun Zhao   +9 more
wiley   +1 more source

Plasmodium falciparum Activates CD16(+) Dendritic Cells to Produce Tumor Necrosis Factor and Interleukin-10 in Subpatent Malaria

, 2019
Background: The malaria causing parasite Plasmodium subverts host immune responses by several strategies including the modulation of dendritic cells (DCs).
Boyle, Michelle J, Kenangalem, Enny, Tipping, Peta E, Anstey, Nicholas M, Piera, Kim A, McCarthy, James S, Minigo, Gabriela, Loughland, Jessica R, Price, Ric N, Woodberry, Tonia, Engwerda, Christian R, Amante, Fiona H   +11 more
core   +1 more source

Gastric cancer increase the percentage of intermediate (CD14++CD16+) and nonclassical (CD14+CD16+) monocytes

Central European Journal of Immunology, 2012
<p>Introduction: Gastric cancer is one of the most common malignancies diagnosed worldwide. Despite therapeutic options, prognosis is unfavorable, particularly when dealing with an advanced stage carcinoma. Similarly to other malignancies, the development of gastric cancer is associated with increased macrophage infiltration.
Jankowski, Michal, Gackowska, Lidia, Helmin-Basa, Anna, Wiese, Malgorzata, Kubiszewska, Izabela, Kaszewski, Wojciech, Michalkiewicz, Jacek, Zegarski, Wojciech   +7 more
openaire   +1 more source